Biomedical subjects
Publications and source records attributed to S Meyer-Hamme.
Over a period of 10 years a 57-year-old patient mainly repairing oil-burner gradually developed spoon-like deformations of his finger nails. A 47-year-old patient observed similar alterations working as a butcher for 4 years. We want to stress the occupational induction of the disease and its therapeutical consequences.
This study reports comparative results of the effects of an aromatic retinoid, etretinate (RO 10-9359), on various disorders of the skin and mucous membranes. One hundred thirteen patients suffering from psoriasis, lichen planus, keratosis follicularis, and various other disorders were treated and examined. The patients received 25 to 100 mg/day of oral etretinate for up to 30 months. Patients with erythrodermic psoriasis, pustular psoriasis, and keratosis follicularis showed the best response. The conditions of patients with psoriasis vulgaris, palmoplantar psoriasis, and lichen planus also improved, but less impressively. The mucous membrane lesions of lichen planus and leukoplakia showed only moderate improvement. The most striking adverse clinical reactions observed were cheilitis (70%), dryness of the mucous membranes (27%), and hair loss (27%).
Photoreactions developed in five of 43 patients being treated for 30 months with repeat doses of DTIC because of metastasing malignant melanoma. An increase in light sensitivity in the UVA and UVB range can be demonstrated by light-testing in the affected patients but not in controls. It shows a decrease with the metabolism of DTIC. The increase in light sensitivity serves as an additional argument to avoid light exposure during and after DTIC injections.
Antisera to mouse brain reacts with hematopoietic stem cells in the mouse bone marrow. We have examined the effect of anti-mouse brain serum (AMBS) on the development of in vitro colonies from mouse bone marrow cells. The addition of 5% AMBS to the cultures markedly decreased the numbers of colonies formed to an average of 10% of the number obtained with normal rabbit serum. AMBS suppressed formation induced by colony stimulating factors (CSF) derived from three different sources; serum from endotoxin treated mice, mouse L-cell conditioned media, and human peripheral mononuclear cell conditioned media. The suppressive activity was quantitatively recovered in the IgG fraction of AMBS. Divalent F(ab')2 fragments were as effective as the intact IgG in decreasing colony formation. Fab fragments were not suppressive. These results suggest that colony formation is induced via a dynamic interaction between CSF and the progenitor cell membrane, and that antibody directed at cell membrane antigen(s) interferes with the generation of the induction signal.
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