PubMed Health⌕ Search

Biomedical subjects

S Mićić

Publications and source records attributed to S Mićić.

At least 19 recordsLinked to original sources
PubMed1999

[Quality of life after retroperitoneal lymphadenectomy in low clinical stages of nonseminomatous testicular tumors].

The surgical complications and quality of life in 139 patients who underwent primary retroperitoneal lymphadenectomy for clinical stage A and B1/B2 non-seminomatous testicular tumors during the period ranging from 1975 to 1997 were reviewed. Bilateral retroperitoneal lymphadenectomy was performed in 26 patients, and modified unilateral in 113 patients. There were 23 complications in 36 patients (16.5%) and only 1 case of surgery-related mortality. There were 28 early complications and 8 late complications. The most frequent minor complication encountered was superficial wound infection, whereas many of the major complications were related to small-bowel obstruction and atelectasis. The complication rate was lower in patients who underwent modified unilateral procedures than in those who had bilateral dissections (76.9:14.5%). The most prominent element of quality of life is preservation of normal ejaculation (69.8%), significantly better preserved in unilateral dissection (80.5:23.1%). This study reinforces the conclusion that primary unilateral retroperitoneal lymphadenectomy is and operation yielding minimal morbidity, excellent quality of life and no long-standing effects.

Humans↗
PubMed1999

[Uretero-cutaneoustomy--indications and quality of life].

Ureterocutaneostomy, the anastomosis of the ureter to the skin, represents the most simple supravesical urinary derivation. It can be performed as unilateral, bilateral, bilateral with one orifice, or rarely as transuretero-ureterocutaneostomy. In period 1993-1998 on the Clinic of Urology, Clinical Center of Serbia, ureterocutaneostomy was performed in 155 patients as definitive type of urinary derivation. The most frequent indication for this type of derivation was the bladder tumor (130 out of 155 pts.). The rest of 25 pts. had carcinoma of vaginal portion of uterus, vesico-vaginal fistula (most frequently after irradiation), high ureteric lesions bladder neurogenic disfunction or rare bladder diseases. Having in mind short period of follow up two major complications were noticed: stenosis of uretero-cutaneostomy and retraction of anastomosis with consecutive formation of subcutaneous urinoma and abscesses formation. Although rarely used as definitive type of urinary anastomosis, ureterocutaneostomy has its place in wide spectrum of urinary derivations, since it is the only way to help those patients that have no other option of urinary derivation that might provide better way of social and professional rehabilitation.

Dermatologic Surgical Procedures↗
PubMed1994

Double minute chromosomes in an invasive adenocarcinoma of the prostate.

Cytogenetic analysis of an uncultured, primary and invasive adenocarcinoma of the prostate showed several clonal abnormalities in a hyperdiploid karyotype, including double minute (dmin) chromosomes. The latter, although sporadic in this type of tumor, were previously reported in two cases of invasive prostatic cancer. This anomaly may therefore be associated with increased malignant properties.

Adenocarcinoma↗
PubMed1992

Cytogenetic evidence of gene amplification in urothelial cancer--a possible mechanism of tumor invasiveness.

A cytogenetically detectable form of gene amplification, presumably oncogene amplification, double minute chromosomes, has been found in 11 out of 45 specimens (24%) of moderately and poorly differentiated, deeply infiltrating transitional cell carcinoma of the bladder and ureter. None of the 75 low-grade low-stage tumors contained this karyotypic anomaly. It is obvious that double minutes are not a rare and sporadic phenomenon in this type of tumors; additionally there is strong evidence that they are involved in tumor progression, i.e. they are associated with tumor aggressiveness and unfavorable prognosis.

Carcinoma, Transitional Cell↗
PubMed1991

An extra X chromosome effect on craniofacial morphogenesis in men.

A comparative study of the craniofacial complex in men with an extra X chromosome, and normal male and female individuals was carried out using cephalometric radiography. The anterior cranial base, anterior and posterior facial height, maxillary base and ascending ramus were found to be significantly decreased in men with Klinefelter syndrome when compared to the male control group. Significant differences in the lengths of mandibular base and posterior cranial base were not found. When compared to the female control, all structures examined were significantly increased, except for the maxillary base.

Adult↗
PubMed1990

Seminal antisperm antibodies and genitourinary infection.

A total of 326 infertile men, 126 with genitourinary tract infection, and 200 without infection, were compared with 60 fertile men. Seminal plasma antisperm antibody with other clinical and microbiologic investigations were performed in all. Infertile men with genitourinary tract infection had antisperm antibody in 11.9 percent, infertile men without infection in 14.5 percent, and fertile men in 5 percent; these differences were not significant. The most common causes of these infections were gram-negative organisms and Chlamydia. Comparison of the levels of the titers of seminal plasma antisperm antibodies showed no significant difference between infertile and fertile men. This study shows no significant relationship between genitourinary tract infection and formation of the seminal antisperm antibody.

Antibodies↗
PubMed1990

Intrauterine insemination with spermatozoa recovered from the aspirate of artificial spermatocoele.

Congenital absence of both vas deferens accounts for approximately 10% of cases of obstructive azoospermia. The purpose of the present study was to develop a treatment protocol for a group of azoospermic patients using surgical implantation of alloplastic spermatocoele to enable repeated sperm cell aspiration. Nine patients with congenital absence of both vas deferens, two with obstructed and one with destroyed vas, underwent surgery for the implantation of an alloplastic spermatocoele. In 10 of the 12 patients, vital spermatozoa were recovered from the aspirate and used for intrauterine insemination of their female partners with induced ovulation, some of whom then conceived.

Female↗
PubMed1990

Phenotype of two males with abnormal Y chromosomes.

Two infertile males with sex chromosomal abnormalities and mosaic karyotype, 45,X/46,X,dic(Yq) and 45,X/46,X,ring(Y), had considerably changed physical findings, including tooth sizes and craniofacial dimensions. Spermatogenesis was preserved with abnormal meiotic chromosomal behaviour. Mosaic karyotype and structurally changed Y chromosome in both cases had an influence on physical parameters. Tests were normally developed and spermatogenesis was preserved but depressed in later stages.

Adult↗
PubMed1989

Distribution of marker chromosomes in relation to histologic grade in bladder cancer.

Cytogenetic analysis was carried out in 100 tissue specimens from 88 patients with bladder cancer. Using a direct technique of chromosome preparation, analyzable metaphases were obtained in 60 cases. Various chromosomal abnormalities, numerical as well as structural, were found. The frequencies of different marker chromosomes, with the exception of the ring chromosome, increased from grade 1 to grade 3 tumors. The average number of markers per cell was one in G1, four in G2, and eight in G3 tumors. It was possible to make a distinction between structural aberrations occurring in all histologic grades and those specific for the invasive grade 2 and grade 3 tumors.

Chromosome Aberrations↗
PubMed1989

Elastase as an indicator of silent genital tract infection in infertile men.

Due to the absence of clinical symptoms, silent genital tract inflammation can be diagnosed only by laboratory tests. In this study we have evaluated seminal plasma elastase levels, using an immunoabsorbent assay, in a group of 84 infertile men. Seminal plasma levels of elastase were correlated with the number of white blood cells in the ejaculate, the number of peroxidase-positive leucocytes and with sperm culture. A high number of leucocytes (greater than 10) and a significantly higher number of men with peroxidase-stained leucocytes exceeding 10(6)/ml was found in a group of men with elastase levels greater than 250 ng/ml. There was a significant correlation between sperm culture results and elastase levels, most men with negative sperm culture having a lower seminal plasma elastase level. Following the treatment with antibiotics of men with an elevated elastase level, sperm parameters improved in 67% of those in whom elastase levels were lowered after treatment. In those men with persisting elevated levels of elastase improvement of sperm parameters was found in only 10%. It is concluded that an elevated level of elastase is a sensitive indicator of asymptomatic genital tract infection and that a single determination gives a reliable criterion and relatively exact quantification of infection.

Adult↗
PubMed1988

Chromosome analysis in patients with bladder tumor.

Cytogenetic analysis was performed in 80 patients with bladder tumor. The mitotic activity in patients with tumor G1, G2 and G3 degree of differentiation was not significantly different among them. Most of the patients with noninvasive tumor (G1) had a diploid or nearly diploid chromosome number, but all patients with invasive (G2 and G3) tumor had polyploidy. Marker chromosomes were found in 14 patients and 9 of them developed recurrence very soon. There is a good correlation between the recurrence rate and numerical or structural chromosomal abnormalities. This study emphasizes the importance of the chromosome analysis in the evaluation of therapy and prognosis for patients with bladder tumors.

Adult↗
PubMed1987

Spermatogenesis and meiotic chromosomal behaviour in aged men.

Spermatogenesis and meiotic chromosomal behaviour was analysed in a group of males aged 60-80 years. Decreased spermatogenesis was found in most of these aged men although individual differences existed. Chromosomal analysis of cells undergoing diakinesis showed significantly lower chiasma frequency in elderly men, compared with a group of younger control males and also with infertile males.

Adult↗
PubMed1987

Incidence of aetiological factors in testicular obstructive azoospermia.

Testicular exploration was performed in 225 azoospermic men with normal sized testes and normal serum levels of FSH. Thirty-one men had impaired spermatogenesis and the cause of obstruction was found in 46% of the subjects. Thirty-two men had a history of genital tract infection while 18 had a history of genital or inguinal surgery. A history of chest disease was noted in 25 men with obstructive azoospermia. Aplasia of the vasa was present in 9.3% of the group. The epididymis was the site of obstruction in 63% of patients but the cause of epididymal obstruction was unknown in 81 of the 141 men.

Bacterial Infections↗
PubMed1987

Cytogenetic analysis of men with cryptorchidism and reduced fertility.

A cytogenetic chromosomal analysis was performed in 140 infertile men with cryptorchidism--85 with unilateral and 55 with bilateral. The most frequent anomaly was sex chromosomal aneuploidy found in 7.1% of patients. This is significantly higher compared to a group of infertile men with normal descended testes. Other chromosomal anomalies were not more frequent than in infertile men without cryptorchidism.

Bulgaria↗