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Biomedical subjects

S Micera

Publications and source records attributed to S Micera.

14 recordsLinked to original sources
PubMed2005

A novel microstructural approach in tendon viscoelastic modelling at the fibrillar level.

Novel applications in rehabilitation, surgery and tissue engineering require the knowledge of the mechanical behaviour of the tissues at microstructural level. The aim of this work is to investigate the viscoelastic properties of the tendon from the interaction of its biological constituents in the fibrillar network. Traction, relaxation and creep in-vitro tests have been performed on porcine flexor digital tendons. A viscoelastic constitutive equation at finite deformation is presented. The fibrillar deformation modes are described through a network of adaptive links between collagen type I and decorin. The theoretical predictions fit accurately the experimental data. The results of the model demonstrate the mechanical importance of glycosaminoglycan chains of decorin for the differential recruitment and the activation of fibrillar collagen.

Biomechanical Phenomena↗
PubMed2005

Characterization of upper arm synergies during reaching tasks in able-bodied and hemiparetic subjects.

BACKGROUND: In the past, several studies showed the existence of a synergistic behavior between elbow and shoulder joints during reaching movements in able-bodied subjects. The aim of this paper was to characterize the modifications of upper arm synergies during reaching induced by stroke. METHODS: Ten able-bodied right-handed subjects, eight right-handed subjects with hemiparesis affecting the right (dominant) upper limb participated in the experiments. The kinematics of shoulder and elbow joints have been recorded in all the participants during selected reaching movements. From the eight-like plots characterizing the relationship between shoulder and elbow angular velocities, a topological parameter (named as C approximately ) representing the linear approximation of the synergy between the two angular velocities has been extracted. FINDINGS: The results of these experiments showed that C approximately could be used as a figure of merit for the comparison of performance in able-bodied and hemiparetic persons. The hemiparetic subjects showed a significantly higher spreading of the values of C approximately for the different reaching movements when compared with the performance of able-bodied subjects. INTERPRETATION: This work showed that hemiparesis modified upper arm synergies and could provide a protocol for the assessment of upper limb function. Moreover, important applications of this method could be found in the development of biomimetic algorithms for the control of upper extremities during reaching in humanoid robots, and in the design of customized "games" in neurorehabilitation procedures implemented by using robotic and mechatronic platforms.

Adult↗
PubMed2004

Kinematic strategies for lowering of upper limbs during suggestions of heaviness: a real-simulator design.

The aim of the experiment was to study possible differences between the kinematic strategies for the "involuntary" arm lowering of hypnotized highly susceptible subjects (H-Highs) and for the voluntary movement of non-hypnotizable simulators (Sims) during suggestions of arm heaviness (Part I). In addition, a comparison between awake susceptible subjects (W-Highs) and H-Highs was carried out to clarify the specific role of the hypnotic state and hypnotizability (Part II). Subjects' absorption and attentional/imagery capabilities were evaluated through neuropsychological tests. Their arm movements were monitored three-dimensionally at hand, wrist and elbow level through a Polhemus Fastrack system. A final interview collected self-reports concerning the perception of movement involuntariness. Neuropsychological tests showed better "absorption" and imagery capabilities in Highs. In the interview, H-Highs perceived a higher involvement in the task and greater involuntariness and difficulties in contrasting the arm lowering than the Sims. Kinematic analysis showed significant differences between H-Highs and Sims for arm displacements along the vertical axis and on the horizontal plane. In fact, the former lowered the left arm earlier and to a greater degree than the right arm; on the horizontal plane, a forearm flexion was observed for H-Highs on the right side. On comparing W-Highs and H-Highs, hypnosis appeared to magnify the waking motor strategies, but also to induce specific changes, mainly concerning the horizontal plane. These results cannot be interpreted on the basis of "role playing" and socio-cognitive factors. They are believed to be due to a balance between the effectiveness of the frontal executive control towards the selection of behaviors and movement automaticity, which is in line with the neo-dissociation theory of hypnosis.

Adult↗
PubMed2004

A protocol for the assessment of 3D movements of the head in persons with cervical dystonia.

OBJECTIVE: To design and test a protocol for the assessment of neck movements in patients affected by cervical dystonia by using an electromagnetic system. This approach could overcome the limits of the current assessment scales in this specific field. BACKGROUND: Initial assessment and function recovery during treatments are diagnosed by the clinician using outcome scales which present many drawbacks in terms of easiness of use, sensitivity, and reliability. DESIGN: A three-dimensional motion analysis system was used to record six different head movements. METHODS: Six able-bodied subjects and 10 subjects affected by cervical dystonia participated in this study. For the different head movements three kinematic parameters (a symmetry index and two indexes related to the reduction of the range of motion) have been extracted in order to compare the performance of able-bodied and disabled persons. RESULTS: The features selected allowed highlighting of the differences between able-bodied and disabled subjects for the degrees of freedom of the neck. CONCLUSIONS: Using a motion analysis system, three kinematic features were extracted from head movements. They seem to allow a more objective assessment of the disability and a more appropriated strategy for the management of patients affected by cervical dystonia.

Adult↗
PubMed2004

Does hypnotizability affect human upright stance?

Subjects highly (Highs) and low susceptible to hypnosis (Lows) show different imagery and attentional capabilities and also peculiar somatomotor, vegetative and electroencephalographic differences in basal and task conditions. Since attention is one of the main component of hypnotic susceptibility and also a relevant factor for postural control, the aim of the experiment was to study actual differences between Highs and Lows at the eyes closure during upright stance. Visual and motor imagery as well as attentional/disattentional capabilities were evaluated through psychological tests. Posture was monitored though Elite systems during upright stance with open and closed eyes. At the eyes closure, Highs and Lows exhibited a different body sway modulation. Possible different compensation mechanisms are suggested for the two groups and interactions between attentional/arousal systems responsible of hypnotic phenomenology and postural control are underlined.

Adolescent↗
PubMed2002

Control of multifunctional prosthetic hands by processing the electromyographic signal.

The human hand is a complex system, with a large number of degrees of freedom (DoFs), sensors embedded in its structure, actuators and tendons, and a complex hierarchical control. Despite this complexity, the efforts required to the user to carry out the different movements is quite small (albeit after an appropriate and lengthy training). On the contray, prosthetic hands are just a pale replication of the natural hand, with significantly reduced grasping capabilities and no sensory information delivered back to the user. Several attempts have been carried out to develop multifunctional prosthetic devices controlled by electromyographic (EMG) signals (myoelectric hands), harness (kinematic hands), dimensional changes in residual muscles, and so forth, but none ofthese methods permits the "natural" control of more than two DoFs. This article presents a review of the traditional methods used to control artificial hands by means of EMG signal, in both the clinical and research contexts, and introduces what could be the future developments in the control strategy of these devices.

Algorithms↗
PubMed2002

A two DoF finger for a biomechatronic artificial hand.

Current prosthetic hands are basically simple grippers with one or two degrees of freedom, which barely restore the capability of the thumb-index pinch. Although most amputees consider this performance as acceptable for usual tasks, there is ample room for improvement by exploiting recent progresses in mechatronics design and technology. We are developing a novel prosthetic hand featured by multiple degrees of freedom, tactile sensing capabilities, and distributed control. Our main goal is to pursue an integrated design approach in order to fulfill critical requirements such as cosmetics, controllability, low weight, low energy consumption and noiselessness. This approach can be synthesized by the definition "biomechatronic design", which means developing mechatronic systems inspired by living beings and able to work harmoniously with them. This paper describes the first implementation of one single finger of a future biomechatronic hand. The finger has a modular design, which allows to obtain hands with different degrees of freedom and grasping capabilities. Current developments include the implementation of a hand comprising three fingers (opposing thumb, index and middle) and an embedded controller.

Artificial Limbs↗
PubMed2001

Neuro-fuzzy extraction of angular information from muscle afferents for ankle control during standing in paraplegic subjects: an animal model.

This paper is part of a project whose aim is the implementation of closed-loop control of ankle angular position during functional electrical stimulation (FES) assisted standing in paraplegic subjects using natural sensory information. In this paper, a neural fuzzy (NF) model is implemented to extract angular position information from the electroneurographic signals recorded from muscle afferents using cuff electrodes in an animal model. The NF model, named dynamic nonsingleton fuzzy logic system is a Mamdani-like fuzzy system, implemented in the framework of recurrent neural networks. The fuzzification procedure implemented was the nonsingleton technique which has been shown in previous works to be able to take into account the uncertainty in the data. The proposed algorithm was tested in different situations and was able to predict reasonably well the ankle angular trajectories especially for small excursions (as during standing) and when the stimulation sites are far from the registration sites. This suggests it may be possible to use activity from muscle afferents recorded with cuff electrodes for FES closed-loop control of ankle position during quite standing.

Algorithms↗
PubMed2000

On automatic identification of upper-limb movements using small-sized training sets of EMG signals.

We evaluate the performance of a variety of neural and fuzzy networks for discrimination among three planar arm-pointing movements by means of electromyographic (EMG) signals, when learning is based on small-sized training sets. The aim of this work is to underline the importance that the sparse data problem has in designing pattern classifiers with good generalisation properties. The results indicate that one of the proposed fuzzy networks is more robust than the other classifiers when working with small training sets.

Arm↗
PubMed1999

Adaptive fuzzy control of electrically stimulated muscles for arm movements.

A modified adaptive Takagi-Sugeno (TS) fuzzy logic controller (FLC) is proposed that allows a simulated elbow-like biomechanical system to accurately track sigmoidal and sinusoidal trajectories in the sagittal plane. The work is a first effort towards the implementation of a system to restore elbow movements in quadriplegics using functional neuromuscular stimulation. The single-joint musculo-skeletal system is composed of a co-contractable pair of electrically stimulated muscles; the muscle model accounts for the increase in fatigue during the tracking exercise. In the proposed controller structure, a reinforcement learning scheme is used to accomplish the parameter tuning, and the parameter projection algorithm guarantees the system stability during the adaptation process. The controller performance is evaluated using computer simulation experiments and compared with the performance achievable when a standard proportional-integrative-derivative (PID) controller is employed for the same application. The modified adaptive TSFLC outperforms the PID controller in all tested situations, with a clear-cut advantage in the case of high-frequency sinusoidal trajectories (angular frequencies spanning the interval 8-12 rad s-1). The standard controller suffers from a dramatic increase in root mean square (RMS) tracking error above the value at 8 rad s-1, e.g. ERMS > or = 0.013, whereas the correlation coefficient between the actual and desired trajectory falls almost to zero, starting from the value rho approximately equal to 0.97 at 8 rad s-1. On the other hand, the adaptive TSFLC yields ERMS < or = 0.015, with rho > or = 0.78, over the whole range of tested angular frequencies.

Arm↗
PubMed1999

A hybrid approach to EMG pattern analysis for classification of arm movements using statistical and fuzzy techniques.

In this paper, a hybrid approach is presented for discriminating a few upper limb movements by processing the electromyographic (EMG) signals from selected shoulder muscles. Statistical techniques, such as the Generalized Likelihood Ratio test, the Principal Component Analysis, autoregressive parametric modeling techniques and cepstral analysis techniques, combined with a fuzzy logic based classifier (the Abe-Lan network) are used to construct low-dimensional feature spaces with high classification rates. The experimental results show the ability of the algorithm to correctly classify all the EMG patterns related to the selected planar arm pointing movements. Moreover, the structure presented offers promise for real-time applications because of the low computation costs of the overall algorithm.

Adult↗
PubMed1998

An algorithm for detecting the onset of muscle contraction by EMG signal processing.

The Generalized Likelihood Ratio (GLR) test is proposed for estimating the time instant of muscle contraction onset via electromyographic (EMG) signal processing. In contrast to commonly used threshold-based estimation methods, the proposed algorithm proves to be reasonably accurate even for low levels of EMG activity; the improved behaviour of the GLR test comes with just a modest increase in the computational complexity. A set of computer simulation experiments are presented, where the proposed algorithm and two different threshold-based estimators are studied; also, we discuss the results of analysing the EMG recordings of selected proximal muscles of the upper limb in a hemiparetic subject.

Algorithms↗
PubMed1998

Neural interfaces for regenerated nerve stimulation and recording.

A class of implantable, regeneration-type neural interfaces (NI's) for mammalian peripheral nerve recording and stimulation were developed using different fabrication processes and integrating purposely designed components. A typical NI comprises three main components: 1) a microfabricated silicon die incorporating a microelectrode array on multiple through-holes, 2) a polymer guidance channel housing the die, and 3) a flexible flat cable connecting the die to an external electronic circuitry. The design and fabrication of the NI's were aimed at achieving long term, reliable implants by taking into careful account the biological, electrical, and mechanical requirements of the specific implant site. Different versions of the NI were fabricated and implanted between the severed ends of the sciatic nerve in a mammalian animal model (rabbit). Morphological and histological evidence showed that nerves regenerated through the NI's and electrophysiological results demonstrated the recovery of electrical functionality. Moreover, the NI's allowed stimulation of the regenerated nerve producing a visible leg/foot contraction. The NI's presented in this paper are being further improved in the authors' laboratories with the ultimate goal of allowing the control of nerve motor and sensory functions in future prosthetic devices.

Action Potentials↗