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Biomedical subjects

S Milanov

Publications and source records attributed to S Milanov.

At least 91 records · Page 5Linked to original sources
PubMedDate not supplied

[The functional state of the hypothalamo-hypophyseal system in tumors of the pituitary and diencephalic area].

A study was made of 38 persons, including 25--with acromegaly, 5--with chromophobic adenomas of the hypophysis, 3--with diencephalic tumours and 5 healthy individuals. STH, TTH and ACTH were determined in the blood plasma with the aid of radioimmunological methods under basic conditions and L-DOPA loading (10 mg per 1 kg of weight) with insulin (0.10 U/kg). There was an increase in the plasma content of STH, TTH and ACTH with a maximum 60 min after the administration of L-DOPA. In the patients with acromegaly STH increased considerably, and in cases with chromophobic adenomas and diencephalic tumours--less. ACTH level was also elevated. STH and ACTH level rose after insulin hypoglycemia. Possible mechanisms of a stimulating action of L-DOPA and insulin are discussed.

Acromegaly↗
PubMedDate not supplied

Plasma growth hormone level in the Morgagni-Stewart-Morel syndrome.

In 10 patients with Morgagni-Stewart-Morel syndrome the basal plasma growth hormone level was slightly increased. There was no decrease of plasma growth hormone after glucose loading in most of the patients. These findings were supported by the histological picture of the adenohypophysis of an accidentally died patient. A microadenomatosis of adenohypophysis consisting of acidophils or basophils was found. The increased growth hormone secretion might be responsible for the hyperostosis and some other features of the Morgagni-Stewart-Morel syndrome.

Acromegaly↗