Biomedical subjects

S Milchgrub

Publications and source records attributed to S Milchgrub.

45 records · Page 3Linked to original sources

PubMed1992

Case report 692: Synovial chondrometaplasia of the 1st costovertebral joint.

Synovial chondrometaplasia, also known as synovial chondromatosis, is a rare disease affecting the synovial membrane and characterized by a nodular proliferation of metaplastic cartilage. It most commonly involves large joints such as the knee, hip, and elbow, but its presence in unusual locations such as small joints and the temporomandibular joint has been described. To our knowledge, this is the first case report of synovial chondrometaplasia involving the costovertebral joint in a patient with a previous injury to that area.

Adult↗

PubMed1992

Malignant histiocytic neoplasms of the small intestine.

Immunologic studies have demonstrated that the vast majority of hematolymphoid neoplasms previously designated as "histiocytic" are lymphoid in origin. Consequently, malignancies of macrophage lineage are considered rare by most authors; indeed, their existence is doubted by some. Herein we report two cases of malignant histiocytic neoplasms (malignancies of macrophage lineage) of the small intestine. Both patients presented in the 7th decade with symptoms related to an abdominal mass. The polypoid tumors protruded into the intestinal lumen, extended through the entire thickness of the bowel wall, and involved regional lymph nodes. Microscopically, sheets of large pleomorphic histiocytic cells infiltrated around crypts and were associated with an admixture of bizarre giant cells and inflammatory cells. Mitotic figures were easily found. Ultrastructurally, the cells lacked desmosomes and had indented or kidney-shaped nuclei and cytoplasm containing mostly lysosomes and dense lipid droplets. In both cases, paraffin section immunohistochemistry revealed reactivity of tumor cells for CD45RB (LCA), CD45RO (A6), CD68 (KP1), CD15 (LeuM1), and lysozyme. Frozen section immunohistochemistry performed in one case further supported the macrophage phenotype. Southern blot studies of this case did not reveal immunoglobulin or T-cell receptor beta chain gene rearrangements. One patient initially treated by surgery only died of disease 3 years after diagnosis. The second patient is alive and disease-free 2 years following postoperative combination chemotherapy. The diagnosis of malignant histiocytic neoplasms requires the use of a panel of immunohistochemical markers and may be supported by electron-microscopic studies.

Antigens, CD↗

PubMed1992

The solid variant of adenoid cystic carcinoma of the cervix.

We studied seven examples of the solid variant of adenoid cystic carcinoma of the uterine cervix in postmenopausal women who presented with vaginal bleeding and a large ulcerated or polypoid cervical mass. The tumors lacked the characteristic cribriform pattern of conventional adenoid cystic carcinoma. The neoplastic cells were small, undifferentiated, or basaloid and grew in cords, nests, trabeculae, and nodules. Foci of squamous cell carcinoma were seen in three tumors and areas of necrosis in four. A characteristic feature was the production of abundant periodic acid-Schiff's procedure (PAS)-positive basement membrane material that was immunoreactive for collagen IV and that in some areas compressed tumor cells. Electron microscopy on three cases showed globules and cylinders of redundant basal lamina. The tumor cells were joined by desmosomes and contained bundles of tonofilaments. Material similar to basement membrane material appeared to be intracytoplasmic in two tumors. No neurosecretory granules or myoepithelial cells were found. Four deaths were tumor related. Two patients are currently alive, but with local recurrence or metastases; another is alive and well 19 months after surgery. We believe that the solid variant of adenoid cystic carcinoma of the cervix is a distinctive neoplasm that should be separated from small cell carcinomas with or without endocrine features, adenoid basal cell carcinoma, and squamous cell carcinoma.

Aged↗

PubMed1991

Adrenal carcinoma presenting as a lesion resembling cutaneous angiosarcoma.

A case is reported of adrenal carcinoma presenting as an angiosarcoma-like metastasis in the scalp. Adrenal carcinoma is a rare tumor, and it metastasizes to skin rarely. The authors discuss the features of this tumor that led to a diagnosis of angiosarcoma and the means by which such a metastasis may be distinguished from vascular tumors.

Adrenal Cortex Neoplasms↗

PubMed1991

Arias-Stella reaction in fallopian tube epithelium. A light and electron microscopic study with a review of the literature.

Most pathologists are familiar with the Arias-Stella reaction in the endometrium, because it is seen in approximately 25% of curettage specimens during early pregnancy. However, the Arias-Stella reaction is exceedingly rare in the fallopian tube, and may be confused with herpetic infection or malignancy. This may result in unnecessary therapy. The authors present a case of Arias-Stella reaction in the fallopian tube and discuss the differential diagnosis of this condition.

Adult↗

PubMed1990

Chondrolipoangioma. A cartilage-containing benign mesenchymoma of soft tissue.

The clinical and pathologic features of four cases of benign mesenchymoma in which mature cartilage represented the predominant component are reported. The distinctive histologic feature in all four cases was a lobular proliferation of cartilaginous tissue exhibiting a spectrum of hyaline cartilage, fibrocartilage, myxoid cartilage, and cartilage with ossification and even bone marrow formation, intimately associated with mature adipose tissue and vascular elements. The localization of these tumors was in the proximity of a bone, but not attached to the periosteum or in continuity with a joint. Because these lesions may be mistaken for other cartilaginous neoplasms of soft tissue, recognition of this entity has potentially important diagnostic and therapeutic implications in that mutilating surgery may be avoided.

Adipose Tissue↗

PubMed1990

Granulomatous prostatitis induced by capsule-deficient cryptococcal infection.

A 59-year-old man with prostatism, in otherwise good health, was treated with transurethral prostatectomy and ketoconazole. At microscopic examination of the prostatic tissue he had acute and chronic prostatitis with granulomatous lesions, in the center of which capsular-deficient cryptococcal organisms were demonstrated. The patient was well without evidence of systemic or local infection at 22 months. The differential diagnosis of granulomatous prostatitis is discussed.

Cryptococcosis↗

PubMed1977

Cytomegaloviral infection presenting as a solitary pulmonary nodule.

Cytomegaloviral infection presenting in an immunologically compromised host as a solitary pulmonary nodule has not previously been reported. A patient with a renal transplant and with no pulmonary symptoms was noted to have a single nodule on a chest roentgenogram. At autopsy, this proved to be secondary to cytomegaloviral infection. Differential diagnostic considerations in the immunosuppressed patient are discussed.

Adult↗

PubMedDate not supplied

A postmortem examination of poly-L lactic acid interference screws 4 months after implantation during anterior cruciate ligament reconstruction.

This is a report of a postmortem examination of an implanted bioabsorbable interference screw used for patellar tendon graft fixation during anterior cruciate ligament reconstruction. Examination was conducted 4 months after implantation. Examination included radiographic, arthroscopic, and magnetic resonance evaluations as well as histologic and mechanical pullout testing. Examination showed no evidence of tunnel widening, lytic bone changes, or inflammatory or foreign body reaction. Pullout and histologic testing indicated that appropriate bone plug incorporation was occurring. We believe the results of this case suggest that the use of bioabsorbable poly-L lactic acid interference screws is a safe and efficacious alternative to metallic screws during anterior cruciate ligament reconstruction.

Adult↗