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Biomedical subjects

S Milner

Publications and source records attributed to S Milner.

At least 37 records · Page 2Linked to original sources

Intracranial arteriovenous fistulas in infancy--haemodynamic considerations.

The clinical, electrocardiographic and radiological features and cardiac catheterization findings in 3 young infants with large intracranial arteriovenous fistulas are presented. In addition to the congestive cardiac failure, the haemodynamic disturbances which give rise to central cyanosis, pulmonary hypertension and, in some instances, poor peripheral pulses, are discussed. The cyanosis in these children may have been the result of a combination of right-to-left shunting at atrial or ductal level, as well as intrapulmonary shunting in association with pulmonary engorgement. Left ventricular dysfunction, with elevated end-diastolic pressures, appeared to be most marked in those cases in which poor peripheral pulses were present. Increased pulmonary arterial pressures (considerably greater than systemic arterial pressure in 2 of the cases) are considered to be due to a combination of the obligatory left-to-right shunt which results from the fistula, and to the super-added effect of altitude (1765 metres) with resultant pulmonary vasoconstriction.

Female↗

Choanal atresia and congenital heart disease.

The association of congenital heart disease with choanal atresia is described in 6 infants (2 White, 3 Black and 1 Coloured). The literature is reviewed and 46 similar cases are analysed. The combination of choanal atresia and congenital heart abnormality generally carries a poor prognosis.

Female↗

Arteriohepatic dysplasia: association of liver disease with pulmonary arterial stenosis as well as facial and skeletal abnormalities.

The clinical features and course of five children with the recently described syndrome of arteriohepatic dysplasia are presented. All had bilateral pulmonary arterial stenosis, proven at cardiac catheterization, as well as associated liver disease of varying severity. In one of the fatal cases, a hitherto undescribed anomaly was found--stenosis of the right coronary artery ostium. A viral etiology, eg, the congenital rubella syndrome, was considered most likely, but detailed investigations proved to be negative.

Abnormalities, Multiple↗

Mitral and tricuspid valve closure in congenital heart disease.

Echocardiography was used to evaluate mitral and tricuspid valve closure in patients 1 day to 20 years of age. When possible, simultaneous phonocardiograms were obtained. The difference in time between the Q wave of the electrocardiogram and mitral closure and between Q and tricuspid closure was designated the delta value. Four groups of patients were assessed: 1) normals (40), secundum atrial septal defect (ASD) (10), mitral valve prolapse syndrome (Barlow's syndrome) (13), pulmonary hypertension (12), and pulmonic stenosis (6); 2) Ebstein's anomaly (10); 3) transposition of the great vessels (15); 4) right bundle branch block (RBBB) (25). Ten patients with surgically induced right bundle branch block were studied by phonocardiography alone. Group I had values of 50 msec or less (-5 to 50 milliseconds) and served as controls. Ebstein's anomaly showed prolongation of the delta value to 65 msec or greater in eight out of ten patients. Patients with transposition of the great vessels showed a striking difference from the preceding groups in that an average negative delta value was obtained. Twenty-two patients of group 4 (RBBB) had delta values within the normal range. This study has shown that a delta value greater than 65 msec is suggestive of Ebstein's anomaly. In addition, if the delta value is negative, transposition of the great vessels can be suspected.

Adolescent↗

Aberrant left pulmonary artery: a rare cause of congenital stridor.

Aberrant left pulmonary artery is a rare cause of stridor and respiratory difficulty in infancy and childhood. Diagnosis can be made on oesophagram, and is confirmed conclusively on angiography. Surgery can be curative, especially in cases without severe associated cardiovascular anomalies. A case report is presented of the condition occurring in a South African Black infant.

Esophageal Stenosis↗

Atrioventricular septal defect and type A postaxial polydactyly without other major associated anomalies: a specific association.

Four children are described, (three black and one white, two boys and two girls) with type A postaxial polydactyly. All four of them, in addition, had either a partial or complete atrioventricular septal defect (AVSD). None of these children had associated major malformations. Minor anomalies were observed (e.g., two patients with hypersegmentation of the sternal segments, one patient with undescended testes, one patient with hypoplastic lumbar vertebra, and one patient with a degree of craniofacial abnormality). Chromosome analysis was carried out for three of the four patients, and was normal in all of them. It is suggested that there is a specific association between type A postaxial polydactyly and the AVSD found in each of these patients. This picture does not conform to, but bears some resemblance to, the Ellis-van Creveld syndrome.

Child↗