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S Mimuro

Publications and source records attributed to S Mimuro.

4 recordsLinked to original sources
PubMed1998

Elevated levels of lipoprotein(a) in women with preeclampsia.

OBJECTIVE: We examined the hypothesis that lipoprotein(a) levels are elevated in preeclampsia and associated with severity of the disease. STUDY DESIGN: Plasma lipoprotein(a) levels were measured in 24 normal pregnant women, 18 mild, and 8 severe preeclamptic women using an enzyme-linked immunosorbent assay method. Kruskall-Wallis one-way analysis of variance was used to evaluate the difference in plasma lipoprotein(a) among different groups. The Mann-Whitney U test was used to compare the differences between two groups. RESULTS: The plasma lipoprotein(a) levels were increased in pregnant women with both severe preeclampsia (median 826.9 mg/L [interquartile range 590.7, 986.9 mg/L], n = 8, p < 0.0001) and mild preeclampsia (median 357.7 mg/L [interquartile range 208.0, 477.1 mg/L], n = 18, p < 0.0001) compared with normal pregnancy (median 78.5 mg/L [interquartile range 45.2, 127.9 mg/L], n = 24). The lipoprotein(a) level was significantly higher in severe than in mild preeclampsia (p < 0.001). CONCLUSION: This study has demonstrated that lipoprotein(a) levels are elevated in preeclampsia and associated with severity of the disease. It may serve as a marker of the pathogenic process.

Adult↗
PubMed1998

Changes of resistance to activated protein C in the course of pregnancy and prevalence of factor V mutation.

The purpose of this study was to examine the changes in activated protein C (APC) anticoagulant activity during pregnancy and determine whether changes in APC could contribute to thrombosis in the placental bed in preeclampsia. We measured APC anticoagulant activity in 150 women with a normal pregnancy and 50 women with preeclampsia. There was a significant reduction in the mean APC sensitivity ratio (APC-SR) during pregnancy (p<0.001). APC resistance in preeclampsia was significantly higher than in normal pregnancy (p<0.01). Amongst women with APC resistance the presence of the factor V Leiden mutation was significantly higher in the preeclampsia group than in the normal pregnancy group (p<0.01). It seems that both factor V Leiden mutation and APC resistance may be associated with the development of preeclampsia. These results suggest that APC resistance may be an important mechanism underlying placental bed pathology in pregnancy and may be associated with an increased tendency to develop preeclampsia in some women. Assay of APC resistance and factor V Leiden mutation should be performed in women with preeclampsia.

Adult↗