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S Minkowitz

Publications and source records attributed to S Minkowitz.

60 records · Page 4Linked to original sources
PubMed1965

Rectal bleeding.

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Colonic Neoplasms↗
PubMedDate not supplied

Primary branchiogenic carcinoma.

An extensive historical review of branchial cleft cyst carcinoma is undertaken and a critical analysis of all 67 cases reported in the English literature since Martin's landmark report is carried out and tabulated. Forty-one of the 67 cases were definitely ruled out as carcinomas of branchial cysts. Though only eight of the remaining 26 cases satisfied Martin's criterion of 5-year follow-up without evidence of primary carcinoma elsewhere, 14 patients had incontrovertible evidence of branchiogenic carcinoma, evidenced by a branchial cyst with histologic evidence of epithelial dysplasia progressing to squamous cell carcinoma within the cyst wall. Two previously unreported cases are presented. A therapeutic approach including wide local excision, radical neck dissection, and radiotherapy is recommended. A more thorough search for an occult head and neck primary, and a clearer understanding of the histopathology of branchiogenic carcinoma, are suggested as alternate requirements for this diagnosis.

Adult↗
PubMedDate not supplied

Total LD and isozyme variations during in vitro fibroblast aging with a discussion of its theoretical implication.

Dermal fibroblast cultures were obtained from 18 patients. Total lactic dehydrogenase (LD) and LD isozymes were determined after each population doubling (PD). The lactic dehydrogenase was assayed by the method of Wacker, Ulmer and Vallee. The isozymes were analyzed by gel electrophoresis. Some investigators have reported conflicting results as to the quantity of LD produced during in vitro aging. These researchers sampled a small number of PDs. We found that the total LD varied with each PD. A distinct isozyme pattern has been described for adult, fetal and neoplastic fibroblasts. We have found all three patterns occurring during the in vitro aging of our normal diploid fibroblasts. In spite of our asynchronous population of cells the LD and its isozymes continually fluctuate. An asynchronous population of cells would be expected to produce a dampening of the total LD. In order to explain this finding we speculate a synchrony is established in a "gated" entrance from subcycle Gq into the S stage or from G1 and G0 into the S stage. In order to evaluate, accurately, changes occurring during in vitro aging it is imperative to assay each PD.

Cell Division↗