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S Mishima

Publications and source records attributed to S Mishima.

13 recordsLinked to original sources
PubMed1992

[Studies on the efficient application by STKS and 8200].

We examined the usefulness of differential leukocyte counts provided by the automated STKS (Coulter) using the VCS method, the cell analyzer 8200 (Hitachi) using the image analysing as compared with that of the traditional manual method. In the STKS, about 8000 leukocytes can be counted within one minute and 5 part differential counts (neutrophils, eosinophils, monocytes, lymphocytes) are provided. The STKS may provided adequate identification of patients who have significant leukocyte abnormalities that require further study. Potential deficiencies of this system included an inability to detect abnormal lymphocytes such as ATL cells. In addition, low numbers of erythroblasts were missed, although these cells could be warned by a flagging system. In the cell analyzer 8200, the differential leukocyte count is done by the microscopic examination of stained blood films which is prepared by automatic device. Results from counts performed with this system correlated well with those obtained by the manual method. This system also missed low numbers of erythroblasts and ATL cells. Another potential deficiencies of the system is that number of cells observed within one minute were limited to about 100. When a prescribed set of cut-off limits, carefully chosen qualitatively, is introduced into these systems, automated leukocyte differential counts, with combination of STKS, 8200 and the manual method, clearly improve turn around time for laboratory blood assessments and this help to reduce unnecessary differential leukocyte counts by the manual method.

Evaluation Studies as Topic↗
PubMed1991

[Professor Jules François Memorial Lecture. Code of ethics and its practice in ophthalmology].

Several Articles are shown from the code of ophthalmological ethics written by late Professor Jules François. Some examples found in the history of ophthalmological practice that complied with these articles are demonstrated. In the modern society with aging population, ophthalmic surgery must be done with great care; long-term prognosis should always be taken into consideration for the patients to be able to maintain high quality of life throughout their life-span. To achieve this, meticulous and continuous care of patients by means of best possible noninvasive techniques must be exercised and this is a conscience of ophthalmologists.

Ethics, Medical↗
PubMed1990

[Antagonism of diazepam-induced sedative effects by flumazenil in patients after surgery under lumbar spinal or epidural anesthesia].

The efficacy and general safety of flumazenil (YM684), a specific benzodiazepine antagonist, have been evaluated. Forty-seven patients scheduled for surgery under lumbar spinal or epidural anesthesia with diazepam sedation received flumazenil at the end of the procedure. Criteria of efficacy were the degree of sedation and antegrade amnesia. Before injection all patients were heavily sedated with the mean dose of 27 mg of diazepam (range 10-50 mg). After the mean dose of 0.21 mg of flumazenil (range 0.2-0.4 mg), all patients were awake or drowsy within 1-6 min but sedation recurred in one patient 1 hour later. The amnesia was eliminated by flumazenil in 34 patients (72%). No serious side-effects or hemodynamic changes were observed after flumazenil. It is concluded that flumazenil is an effective antagonist of sedation induced by diazepam.

Adult↗
PubMed1979

The eighth Frederick H. Verhoeff Lecture. presented by saiichi mishima, MD Behçet's disease in Japan: ophthalmologic aspects.

The problems of Behçet's disease in Japan have been reviewed with particular emphasis on the ophthalmologic aspects: the historical background for the Japanese works, diagnostic critieria, epidemiology, some statistics, ocular symptomatology, ocular histopathology, etiology, pathophysiology, and treatment. Behçet's disease is the most frequent entity in endogenous uveitis in Japan. Patients are found throughout the country, and the prevalence rate averages seven to eight per 100,000 population: the rate is higher in the northern than in the southern districts. The diagnosis is made on the basis of a combination of clinical symptoms that are divided into the major and minor criteria symptoms. The major criteria comprise the ocular involvement, aphthous ulcers of the oral mucous membrane, genital ulcers, and skin lesions. These symptoms recur often as attacks and the disease follows a chronic course. The ocular involvement is found in 83% to 95% in males and 67% to 73% in females; the male to female ratio in the number of patients is 1.78. Both into the anterior segment type and the fundus and panophthalmic types. The anterior segment type shows serous iridocyclitis with the classic type of hypopyon appearing in about 12% of the attacks. This type is found in about 20%, more often in females than in males, and the visual prognosis is more favorable than in the fundus and panophthalmic types. In the latter two types, attacks of retinal angitis resulting in intensive retinal edema, yellowish-white exudate, and hemorrhages recur particularly in the macular region, and the visual prognosis is poor. More than 50% of male patients lose visual acuity to less than 0.1 in five years, but this is the case in only 10% of female patients. Consequently, Behçet's disease is the cause of blindness in about 12% of acquired blindness in adults. The ocular histopathology during the attack is characterized by severe angitis with intensive infiltration of neutrophil leucocytes largely in the uveal tract and the retina; the latter is severely affected and loss of visual cells and other neural elements results. The etiology of this disease still remains unknown but genetic predisposition is suggested since this disease is strongly linked with HL-A-B5. Environmental factors are also considered. Various abnormalities are found in the blood chemistry, blood cells (particularly in neutrophil leucocytes), immunologic mechanism, fibrinolytic and blood clotting system, and hormonal system. Chemotractic factors are found in the aqueous humor. These changes are particulary enhanced just before and during the ocular attacks. Systemic corticosteroids are deleterious to the visual prognosis, but cyclophosphamide and colchicine appear to suppress attacks and help patients maintain the visual acuity. However, these drugs are toxic, particulary to the reproductive organs, and the patients must be informed of this side effect and be allowed to make a decision before they are used.

Adolescent↗
PubMed1977

Breakdown of the blood: aqueous barrier and prostaglandins.

The quantitative relationship between the degree of breakdown of the blood-aqueous barrier and aqueous humor prostaglandin content was studied in rabbits. After the primary aspiration of the aqueous, secondary aqueous humor was sampled. The samples were divided into two parts for the following measurements: one for the degree of the barrier breakdown which was represented by protein content determined by Lowry method and the other for prostaglandin content which was measured by radio-immunoassay. A significant linear relationship was obtained between the protein and prostaglandin E content but not between the protein and prostaglandin F content.

Animals↗
PubMed1977

[Investigations on retinopathia pigmentosa. Statistical analysis of perimetry results (author's transl)].

Kinetic perimetry was carried out using the Goldmann perimeter in 201 patients with primary pigmentary retinal dystrophy, 156 autosomal recessive and 45 autosomal dominant cases. "The advanced stage" of the isopter deterioration was defined as the isopter area with the test object I-4 being 1 cm2 or less on the chart of Goldmann. The frequency of "the advanced stage" cases in creased with age in both hereditary forms, but it was higher in the recessive than in the dominant form throughout all age groups. The frequency-age relationship was exponential as is found in various aging phenomena. Fifty per cent of the patients were in "the advanced stage" at the age of 30 years in the recessive and at the age of 56 years in the dominent form.

Adolescent↗
PubMed1976

Aqueous humor dynamics in glaucomato-cyclitic crisis.

The transfer coefficients of fluorescein in the anterior chamber by flow, kfa, and by diffusion, kdpa, can be calculated for an individual human eye, through an analysis of fluorescein concentrations in the anterior chamber, pupillary aqueous, and serum ultrafiltrates following intravenous injection. Using this technique, aqueous humor dynamics was studied in eight patients with glaucomato-cyclitic crisis. In seven patients, the coefficients determined during the attacks averaged 1.23 +/- 0.08 (S.E.M.) X 10(-2) min.-1 for kfa and 3.51 +/- 0.81 X 10(-3) min.-1 for kdpa in the involved eye, and 0.91 +/- 0.12 X 10(-2) min.-1 for kfa and 1.36 +/- 0.39 X 10(-3) min.-1 for kdpa in the fellow eye. The differences in the coefficients between the two eyes were statistically significant (P less than 0.05). In six patients, the coefficients were measured during the remission, giving average values of 0.81 +/- 0.08 X 10(-2) min.-1 for kfa and 1.36 +/- 0.16 X 10(-3) min.-1 for kdpa in the involved eye, and 0.78 +/- 0.07 X 10(-2) min.-1 for kfa and 1.20 +/- 0.10 X 10(-3) min.-1 for kdpa in the fellow eye. The differences in the coeficients between the two eyes were not significant. In five patients, the determinations were repeated during the attack and remission, and the differences in the coefficients between both phases were statistically significant (P less than 0.05) in the involved eye.

Adult↗