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S Mitrani-Rosenbaum

Publications and source records attributed to S Mitrani-Rosenbaum.

41 records · Page 3Linked to original sources
PubMed1980

Establishment in continuous culture of a T-lymphoid cell line (HD-Mar) from a patient with Hodgkin's lymphoma.

A new cell line, HD-Mar, was established from a pleural effusion of a patient with Hodgkin's lymphoma. Formation of E rosettes, sensitivity to anti-T serum, elevated terminal deoxynucleotidyl transferase activity, presence of T-cell and the common ALL membrane antigens, morphology, and cytochemical staining indicate that the HD-Mar line is of thymic derivation. Absence of any immunoglobulin determinants, the lack of EBNA or any other EBV-associated antigen or function are also characteristics associated with established T-cell-derived lymphoma cell lines. Karyotype analysis indicated a tetraploid origin of the cell line.

Adult↗
PubMedDate not supplied

The inter-relationship of herpes virus, papilloma 16/18 virus infection and Pap smear pathology in Israeli women.

A previous survey of the seroprevalence of the herpes virus type 2 (HSV-2) infection in Israel provided us with an opportunity to study a) the prevalence of human papillomavirus (HPV) 16/18 in selected groups of women; b) the correlation between the infection with HSV-2, HPV-16/18 and Papanicolaou (PAP) pathology; and c) to identify groups of women who might benefit from routine PAP screening. Four different population groups of women aged 17-60 years were studied: groups 1 and 2 comprised healthy women government employees and kibbutz and moshav residents, respectively, and groups 3 and 4 comprised Jewish and non-Jewish women with gynecological complaints. In women without gynecological problems the prevalence of HPV-16/18 was 1.8% in group 1 and 0% in group 2. The prevalence was several-fold higher in the Jewish and non-Jewish gynecological clinic groups, 9% and 12%, respectively. There was no correlation between the prevalence of HSV-2 antibodies and HPV-16/18 infection in women without gynecological problems. One of the 692 women studied had markers of both infections. The very few cases of cervical intraepithelial neoplasia (CIN) II and CIN III occurred in women who were negative for HSV-2 and HPV-16/18 infection. Thus from our limited study, it is not possible to define any group of healthy women who might benefit from continuous PAP smear screening for cervical cancer.

Adolescent↗
PubMedDate not supplied

Human papillomaviruses and the diagnosis of genital microorganisms.

Considerable evidence points to certain types of human papillomaviruses (HPV) as high risk factors in the malignant progression mechanism in lesions of the lower genital tract. Since infection of the genital mucosa by papillomaviruses includes a wide variety of viral types, it is essential to recognize the specific HPV type eventually present in a genital lesion to ensure an appropriate follow-up of the patient. We have developed a polymerase chain reaction (PCR) based assay which differentiates in a single amplification reaction the "malignant" HPV genital types from the "benign" ones. We report also the use of PCR for the detection of other frequent sexually transmitted agents, such as herpes simplex virus and Chlamydia trachomatis. We show that it is possible to design and use a PCR-based assay for the simultaneous detection of various genital agents from a single genital swab. This assay can be a model for the development of additional multidetection systems of microorganisms potentially involved in similar pathologies.

Chlamydia Infections↗