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Biomedical subjects

S Mosca

Publications and source records attributed to S Mosca.

At least 73 records · Page 4Linked to original sources

[Isolated persistent left superior vena cava. Detection of cause during central venous catheterization].

The Authors report the causal discovery of isolated persistent left superior vena cava (IPLSVC) during a central venous incannulation with a Groshong's catheter, in a patient undergoing bone marrow transplant. After a short introduction about the IPLSVC ontogenesis, they stress the need for fluoroscopy during the central venous incannulation. The Authors conclude that the possibility of angiocardiography has been very helpful, in this case, for diagnosis and prognosis.

Angiocardiography↗

Duplex-sonography and color-Doppler evaluation of renal artery stenosis--angiographic correlation.

Echo Doppler has been used in 22 patients with suspected renovascular hypertension (RVH) to detect stenosis or occlusion of the renal artery. In 12 cases duplex Doppler technique was used and in 10 color Doppler. The Doppler examination was always performed before angiography which was considered the reference gold-standard. Using duplex Doppler the diagnosis of RVH was based on qualitative (spectral analysis of the waveform) and semi quantitative parameters (resistive index). With color Doppler two other quantitative parameters were used, peak systolic frequency shift at the level of the stenosis and stenosis index. The color Doppler has shown a better specificity and a better PPV. The sensitivity of the color Doppler was comparable to that of the duplex scanner (89% and 90%, respectively). Further studies are necessary in order to define the diagnostic parameters, the reproducibility and the intra- and interobserver reproducibility. The technological progress may in the future reduce the difficulty and the time of examination.

Adolescent↗

Impedance plethysmography in the diagnosis of asymptomatic deep vein thrombosis in hip surgery. A venography-controlled study.

We prospectively evaluated the accuracy of computerized impedance plethysmography (CIP) in the diagnosis of asymptomatic deep vein thrombosis (DVT) in 246 consecutive high-risk patients scheduled for hip surgery, with bilateral venography used for comparison. The CIP was performed as a surveillance program every third day. If the CIP remained negative, bilateral venography was performed on postoperative day 10 +/- 1 or on day of treatment 14 +/- 1 in nonoperated-on patients. If the CIP became positive, venography was performed within 24 hours. The sensitivity and specificity of CIP for proximal and distal DVT were 19% (confidence interval [CI], 13% to 24%) and 91% (CI, 87% to 94%), respectively. The positive and negative predictive values were 52% (CI, 38% to 65%) and 70% (CI, 65% to 74%), respectively. The sensitivity and specificity of CIP for proximal DVT were 24% (CI, 13% to 34%) and 90% (CI, 87% to 94%), respectively; the positive and negative predictive values were 31% (CI, 20% to 51%) and 87% (CI, 83% to 90%), respectively. We conclude that, because of its low sensitivity, CIP cannot be used in the surveillance of DVT in high-risk patients or for outcome measurements in clinical trials on DVT prophylaxis.

Aged↗

[Impedance plethysmography, Doppler echography and phlebography in deep venous thromboses of the lower limbs].

Computerized impedance plethysmography (CIP) and phlebography were performed on 165 consecutive outpatients with clinical suspicion of deep venous thrombosis (DVT) and on 220 consecutive asymptomatic patients hospitalized for hip fracture. Ninety-two asymptomatic patients were examined also with real-time B-mode US. In orthopedic patients CIP sensitivity, specificity, accuracy, positive and negative predictive values were 19.4%, 90.5%, 64.4%, 53.8% and 66.3%, respectively, for proximal and distal DVT, versus 19.7%, 88%, 77.5%, 77% and 86% for proximal DVT. In symptomatic patients CIP sensitivity, specificity, accuracy, positive and negative predictive values were 83%, 87%, 85%, 87% and 82%, respectively, for proximal and distal DVT, versus 91%, 88%, 89%, 82% and 94% for proximal DVT. CIP had great diagnostic utility in symptomatic DVT, whereas its diagnostic efficacy was low in asymptomatic patients. In orthopedic patients US sensitivity, specificity positive and negative predictive values were 44%, 99.2%, 95.7% and 81.6%, respectively. US diagnostic value was relatively high, but further investigation is needed. To date, phlebography seems to be the only effective method in the diagnosis of DVT in asymptomatic high risk patients.

Diagnosis, Computer-Assisted↗

Quantitative clinical anatomy of the pancreatic arteries studied by selective celiac angiography.

The angiographic visualization of the pancreatic arteries, their numerical variations, origins, course and anastomoses, as well as their mean diameter by age-group (20-40, 41-60, greater than 60 years) have been quantitatively investigated by selective celiac angiography in 72 patients without pancreatic disease. Visualization of the various arteries was achieved in a high percentage of cases except for the inferior pancreaticoduodenal arches, due to undervaluation of this vessel by celiac angiography. Confirmation of the great variability of the origin and anastomoses of the dorsal and transverse pancreatic arteries was obtained and possible embryologic reasons and clinical implications of this fact are discussed. Furthermore, a high percentage of multiple (quadruple or more) pancreatica magna and caudae pancreatis arteries has been observed and a functional role of this peculiar arrangement is suggested. Finally, no statistically significant differences were found in the diameter of any artery due to increasing age, probably reflecting maintained neural perivascular control of the pancreatic vessels in the elderly. Satisfactory sensitivity of the angiographic method has been found with respect to the evaluation of visualization and anastomoses of the pancreatic arteries in vivo.

Adult↗

Clinical anatomy of the suprarenal arteries: a quantitative approach by aortography.

The angiographic visualization, arterial origin and mean diameter per age group (20-40, 41-60 years) of the suprarenal arterial vessels have been quantitatively investigated by aortography in 100 patients without suprarenal disease. Visualization of the various arteries was achieved in a percentage substantially comparable to the anatomic data of the literature, though with lower detection of the superior suprarenal vessels. A variable site of origin was present particularly for the superior and middle suprarenal vessels compared to the inferior suprarenal arteries and possible embryological reasons and clinical implications are discussed. Statistically significant differences were found in the mean diameter of each arterial vessel in all the subjects examined, thus substantiating the concept of differential arterial supply to various portions of the gland. Age-related changes were demonstrated in the right middle suprarenal artery, suggesting a predominant role of this vessel in the physiological adaptation of the blood supply to the gland with increasing age.

Adrenal Glands↗

Selective thrombolysis with low-dose urokinase in chronic arteriosclerotic obstructions.

Twenty-one patients, 15 males and 6 females aged 52-75 years, with angiographically demonstrated occlusions of the superficial femoral or popliteal arteries, were treated by low-dose urokinase intraarterial infusion. The obstructions were 2-12 months old and from 7 to 18 cm in length. Urokinase was infused at 50,000 U/h; heparin was simultaneously administered by intravenous route in doses of 800 U/h. The average duration of treatment was 18 h. Effective clot lysis was accomplished in 18 cases (85%); 15 patients had underlying stenoses treated by balloon dilatation to prevent rethrombosis. Of the primarily recanalized arteries, two reoccluted within 4 weeks.

Aged↗

[Percutaneous transluminal angioplasty of the vascular area of the lower limbs. Current indications].

Usual indications for percutaneous transluminal angioplasty (PTA) in the vascular district of the lower limbs are single stenoses, short multiple stenoses and obstructions--shorter than 8 cm--in Fontaine's stage II, III and IV patients. Our experience is based on 642 PTAs carried out for obliterative arteriopathy of the lower limbs over a 6-year period. In agreement with the literature, we believe that today these indications can be extended to "limb salvage", to chronic femoral-popliteal obstructions longer than 8 cm and of a duration of less than one year, treated also with loco-regional fibrinolysis, and to asymptomatic lesions. Our series of patients include 15 treatments for "limb salvage", 21 chronic femoral-popliteal obstructions and 5 cases with bilateral lesions. The latter were treated with PTA only on the symptomatic side: later angiographic controls demonstrated a progressive deterioration only on the asymptomatic side. Immediate results were positive in 86% of the "limb salvage" cases and in 85% of the chronic femoral-popliteal obstructions. The advantages are discussed of PTA in the above-mentioned cases, paying also attention to the cost-benefit ratio.

Angiography↗

Manometric and pH-metric features in gastro-oesophageal reflux disease patients with and without Helicobacter pylori infection.

BACKGROUND: The role of Helicobacter pylori in the pathogenesis and evolution of gastro-oesophageal reflux disease is still debated. AIM: To investigate the impact of Helicobacter pylori infection on the oesophageal function and on intra-gastric and intra-oesophageal pH in patients with gastro-oesophageal reflux. METHODS: Fifty patients with non-complicated-gastro-oesophageal reflux disease classified according to Savary-Miller in: grade O, n=24; grade 1, n=19; grade 2, n=6; grade 3, n=1. Of these patients, 24 were Helicobacter pylori positive and 26 negative. Patients underwent, on two different days, stationary oesophageal manometry and 24-hour gastro-oesophageal pH-metry. RESULTS: No difference was observed between Helicobacter pylori infected and non-infected individuals with regard to lower oesophageal sphincter function, oesophageal peristalsis and gastrooesophageal reflux. These parameters were more impaired in individuals with erosive gastro-oesophageal reflux disease but this result was not dependent on the Helicobacter pylori status. Helicobacter pylori did not influence the pattern of gastric pH; however, considering only individuals with non-erosive gastro-oesophageal reflux disease, gastric pH was significantly higher in infected individuals, who, histologically, also showed a corpus predominant gastritis. CONCLUSIONS: In patients with gastro-oesophageal reflux disease, Helicobacter pylori does not affect the oesophageal motility or the gastro-oesophageal reflux. These parameters are strictly related to the severity of gastro-oesophageal reflux disease as assessed at endoscopy. In patients with non-erosive gastro-oesophageal reflux disease, a corpus predominant Helicobacter pylori gastritis could be responsible for the less severe gastro-oesophageal reflux.

Adult↗