Isolation and partial characterization of a nuclear RNA polymerase - SV40 DNA complex.
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Biomedical subjects
Publications and source records attributed to S Mousset.
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We have purified from adult rat liver proteic fractions, which inhibit the cellular growth of cell cultures. These fractions, when they are injected into hepatectomised rats, were able to inhibit the entry of hepatic cells into phase S. Therefore we consider that these substances participate actively in homeostatic control in adult liver.
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Transformation of permanent rodent fibroblast cells by the polyoma virus middle T gene or the activated human Harvey-ras oncogene results in increased cellular permissiveness to the autonomous parvovirus minute-virus-of-mice. Parvoviral DNA amplification is restricted in the untransformed parental cell lines. Analysis of various parameters of the parvoviral life cycle shows that this block is partially overcome in the transformed lines.