Implementation of HIV postexposure prophylaxis guidelines.
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Biomedical subjects
Publications and source records attributed to S Moyer.
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To assess the impact of the 1978 Canadian gun control law on suicide rates in Ontario, the authors compared firearm and nonfirearm suicide rates for 1965-1977 with those for 1979-1989. There was a decrease in level and trend over time of firearm and total suicide rates and no indication of substitution of other methods. These decreases may be only partly due to the legislation.
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The Sendai virus V protein, which is a fusion of the P and V ORFs of the P gene, was characterized with antisera to a portion of the V ORF and compared to the P protein. The only property found in common with P is that V is also highly phosphorylated, and this is so even when these proteins are expressed independently of the other viral proteins. Otherwise, V was not found in virions, was not strongly associated with viral nucleocapsids like P, and anti-V had no effect on viral RNA synthesis in vitro under conditions where anti-P was highly inhibitory. The available evidence suggests that V may play a role in RNA synthesis, but it is not an essential one like that of the P protein.
Three-hundred eleven tree holes were sampled for Culicoides at 27 localities in Colorado, Kansas, Nebraska, Oklahoma and South Dakota. Of the 311 samples taken, 170 produced specimens, and 2,899 Culicoides were collected including 12 species. The 5 most common species (number collected) were C. guttipennis (1,468), C. arboricola (355), C. paraensis (292), C. elemae (186) and C. footei (159). Other species collected were C. villosipennis, C. nanus, C. hinmani, C. oklahomensis, C. snowi, C. lahillei and C. byersi. New state records include C. byersi and C. arboricola for Colorado; C. arboricola for Wyoming; and C. lahillei, C. elemae, C. nanus and C. paraensis for Oklahoma. Culicoides byersi, whose larval habitat was previously unknown, was reared from a cottonwood tree hole.
Naproxen sodium is a drug characterized by rapid and complete absorption after oral administration, highly protein-bound distribution, relatively simple metabolism, and renal excretion. Its pharmacokinetics are little affected by food, by dosage levels (within wide limits), or by mild renal impairment. The main mechanism of naproxen sodium action, inhibition of prostaglandin synthesis, makes the drug effective in combating pain and inflammation, while its relatively long half-life permits a two times daily dosing. The drug is well tolerated by most patients.
Defective interfering particles of vesicular stomatitis virus have been named according to their parental derivation and to their genomic length and physical properties. This suggested uniform nomenclature can be adapted for other virus systems.
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