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Biomedical subjects

S Mozes

Publications and source records attributed to S Mozes.

At least 37 records · Page 2Linked to original sources
PubMed1988

Effects of bovine growth hormone in infant rats from reduced litters.

The objective of this study was to determine the effects of growth hormone on body growth and the content of RNA, DNA and protein in liver, brain and heart muscle in rat pups from reduced nests. Suckling rats raised in litters of 4 youngs were daily injected from 3rd to 28th day of life with 1 microgram of bGH/g body weight. Our results show that GH administration evoked higher body weight gain and increase of tail length after 23rd day of life. There was significant increase of liver content of nucleic acids and protein. This GH-responsivity of pups from reduced nests might be related to differences in their metabolic profile and accelerated somatic and psychosocial development in comparison to normal youngs.

Animals↗
PubMed1988

Effects of bovine growth hormone in suckling lambs.

The objective of this study was to determine the effects of bovine growth hormone (bGH) on body growth of suckling lambs. Suckling Merino lambs (fed on milk replacer from 4th day of life) were daily injected from 10th to 38th day of life with 80 micrograms bGH/kg b.w. Only insignificant increase of body weight was observed after 4 weeks of GH treatment. After 31st day of life body weight gain in the experimental lambs was significantly higher. It can be concluded that bGH increases body weight gain of lambs in 2nd month of life. It is probable that growth rate of sucklings is limited only by biological and biochemical capabilities of the organism and it can be hardly influenced by exogenous hormonal manipulation.

Animals↗
PubMed1988

Plasma insulin and glucose in suckling and ruminating lambs after peroral administration of glucose and propionate.

An identical volume of water solutions: 1) glucose 5.56 mmol/kg b.w., or 2) sodium propionate 5.56 mmol/kg b.w., was given perorally to sucklings (6 weeks) and weaned lambs (10 weeks). The maximum increase of glycemia and the highest insulin concentrations were observed 60-90 min after glucose administration in both groups of lambs. Plasma insulin of suckling and weaned lambs was increased within 60 min after propionate infusion. It can be concluded that propionate is a potent insulin secretagogue in sucklings as well as in ruminating ones. However, glucose is probably the most effective stimulus for insulin release in both groups of lambs.

Administration, Oral↗
PubMed1988

Effects of ovine prolactin in infant rats.

The objective of this study was to determine the effects of ovine prolactin (oPRL) on body growth and the content of RNA, DNA and protein in liver, brain and heart muscle in rat pups. Suckling rats were daily injected from 3rd to 28th day of life with 1 microgram of oPRL/g body weight. Our results show that oPRL administration evoked higher body weight gain up to 8th day of life (p less than 0.05). There was significant (p less than 0.05) increase of DNA liver content and significant decrease (p less than 0.001) of RNA/DNA ratio in the hepatocytes. The findings suggest that prolactin influences growth rate of rats in the early postnatal period of life.

Animals↗
PubMed1988

Food intake of infant rats after intraperitoneal administration of insulin.

The effects of intraperitoneal insulin on the food intake have been determined in infant rats up to weaning. It was found that intraperitoneal (IP) insulin reduced the milk intake of 13 and 17 day-old pups for three hours after treatment. In 5, 9 and 24 day-old pups the food intake was not significantly changed after IP insulin administration. Only in 28 day-old rat pups IP insulin induced an increase of food intake. Since subcutaneously (SC) administered insulin gave rise to short-term hyperphagia in 24 day-old rat pups we assessed the effects of SC versus IP insulin on the blood glucose level. Blood glucose was lower 3 hours after SC administration compared to the IP route. Results indicate that IP insulin causes a short lasting hypoglycaemia and consequently IP insulin increases food intake only after the 28th day of life.

Aging↗
PubMed1987

[Regulation of milk intake in young ruminants].

We studied the influence of the three main nutritive components of milk - saccharides, fat and amino acids - on milk intake in suckling lambs and on the role of insulin as a key metabolic hormone for the regulation of milk intake. The intake was slowed down after p.o. administration of milk fat (p less than 0.05), after i. v. administration of methionine (p less than 0.001) and after p. o. administration of glucose, lactose (p less than 0.01, p less than 0.001) and sorbitol (p less than 0.001). After i. v. administration of glycerol, lysine, threonine, arginine, glucose, and i. v. and p. o. administration of galactose the intake of milk did not change significantly (p greater than 0.05). The findings indicate that the short-time regulation of milk intake in suckling ruminant animals is not subjected to the specific effect of some of the milk components. Regarding the metabolic effects, the problem concerns the speed of resorption of easily metabolizable sources of energy from the digestive system to the liver and to the whole body. Neutral Zn-insulin administered intraperitoneally at a dose of 4 U X kg-1 increased the milk intake (p less than 0.01, p less than 0.001), in 8 to 22 hours after the administration only when the animals were on the low-fat milk diet (5.9%-11% fat in dry matter). We assume that the long-range hyperphagy can be related mainly with the fast metabolizing of energy-rich substances (glucose) into the body stores (glycogen, fat) accompanied by subsequent hormonal changes.(ABSTRACT TRUNCATED AT 250 WORDS)

Amino Acids↗
PubMed1984

Food intake control and RNA content of hypothalamic neurons in infant rats.

The influence of glycerol, glucose and lysine administration on the total RNA content in individual neurons of the ventromedial hypothalamus (VMH) and lateral hypothalamus area (LHA) in infant male rats was studied. Sixty minutes after administration, the total RNA content of the VMH neurons significantly decreased--from 13th day after glycerol and from 17th day after the glucose and lysine administration. The total RNA content of LHA neurons significantly increased from 17th day after glycerol and glucose and on 25th day after lysine administration. The noted changes of the RNA content, and especially the changes of the RNA proportion in these hypothalamic regions are well corresponding with the onset of the hypophagic effect of glycerol, glucose and amino acids in infant rats. The oppositional changes of the RNA content of VMH and LHA neurons are in conformity with the different role of these hypothalamic centers in food intake control.

Age Factors↗
PubMed1983

Food intake of suckling rats after administration of glucose and amino acids.

The changes of food intake after administration of glucose or a mixture of amino acids were determined in rat pups from the 5th to the 23rd day of life. The milk intake was significantly reduced 90 min after glucose treatment in 17 day-old pups, while decreased food intake after injection of aminoacids was observed only after the 23rd day of life. It is being concluded that the regulation of food intake in correlation to the blood concentrations of various key metabolic factors develops gradually during the suckling period, depending on the development of the CNS and on changes in diet composition.

Amino Acids, Essential↗
PubMed1982

Effect of subcutaneous and intraperitoneal administration of insulin on the milk intake of suckling lambs.

Intraperitoneal or subcutaneous injections of Neutral Zn-insulin (4 U/kg b.w.) were given to suckling lambs. Milk intake was significantly increased 8 h and 22 h after intraperitoneal insulin administration; the subcutaneous injection was ineffective. Insulin levels and serum glucose changes were similar in both experimental groups, but we observed significant decrease in total lipids /2 1/2 h, 5 1/2 h), a rise in serum triglycerides (7 3/4 h) and increased serum thyroxine levels (5 1/2 h, 7 3/4 h) after intraperitoneal insulin administration. It is assumed, that intraperitoneal (not subcutaneous) insulin evokes specific biological responses resulting in long lasting hyperphagy in suckling lambs.

Animal Population Groups↗
PubMed1982

Effect of insulin and 2-deoxy-d-glucose on the food intake of infant rats.

The effects of glucoprivation on the food intake have been determined in infant rats up to weaning. It was found that insulin reduced the milk intake of 9, 13 and 17-day-old males and females for three hours after treatment. In 24-day-old pups food intake increased for three hours after insulin administration, and decreased during the next 21-hour period. 2-deoxy-D-glucose increased the food intake in 28-day-old rat pups only. It was concluded that the inability of rat pups to correct glucoprivation by a subsequent increase of food intake is a consequence of the inadequate development of hypothalamic regulatory mechanisms. Glucoprivation stimuli are ineffective inducers of short-term hyperphagia of rat pups until the age of 24-28 days.

Animal Population Groups↗
PubMed1982

[Changes in blood sugar after administration of xylazine and adrenergic blockers in the rat].

Xylazine (rompun) has sedative, analgetic and myorelaxative effects; in addition to this, it also influences the homeostasis of glucose in the organism. The changes in glucose tolerance were studied in young rats after the administration of xylazine in combination with the blockers of adrenergic receptors. Xylazine caused hyperglycaemia and glucose intolerance in young rats and the administration of the beta-adrenergic blocker (propranolol) prolonged this diabetogenic effect. On the other hand, glucose tolerance after the administration of xylazine with alpha-adrenergic blocker (phentolamine) is close to the normal level. It is supposed on the basis of our results that xylazine-induced glucose intolerance and hyperglycaemia are mediated by the stimulation of the alpha-adrenergic system. Besides inhibition of insulin secretion, hepatic glycogenolysis probably also increases.

Animals↗
PubMed1982

The effect of androgen and estrogen on food intake and body weight in rats--age dependency.

The age dependency of changes in food intake and body weight in Wistar rats after androgen and estrogen treatment was followed. The 5 age categories of female rats were treated by androgen and the 6 age categories of male rats were treated by estrogen. The androgen treatment induced an expressive increase in weight gains in all age categories of female rats, except the 1st (after birth), during 25 days from the beginning of the experiments. The increase of weight gains resulted in significantly higher body weight on the 25th day of experiments in the experimental rats. The differences in weight gains among the individual experimental groups after androgen treatment show a rising effect with the age of the animals. There was only a slight increase of food intake in the older experimental groups during the androgen treatment. The estrogen treatment in male rats induced an expressive decrease in weight gains in the 2nd age category (after weaning) and losses of body weight in older experimental groups during 20 days from the beginning of the treatment. The body weight of experimental animals on the 20th day was significantly lower than in the control ones. The losses of the body weight after the estrogen treatment rose with the age of the rats. The food intake was also considerably decreased by estrogen treatments, approximately equally in all experimental groups. The comparison of magnitude of the changes in food intake and body weight after androgen and estrogen treatments indicates that the primary effect of these hormones is their anabolic or catabolic activity which secondarily induces the changes in food intake and its utilization.

Aging↗
PubMed1981

Total content of RNA in individual nerve cells of spinal ganglion during ischemia in dogs.

The total RNA content in the individual nerve cells of the lumbal spinal ganglia in the dog after the 80 minutes lasting partial ischemia was followed. The spinal ganglion neurons did not react in ischemia in the same way. The total RNA content in the individual neurons of the control animals occurred in the range 132-990 arbitrary units, after the ischemia in the range 116-670 arbitrary units. In both groups the cells with the low or high RNA content were seen. The decreases in total RNA content after ischemia was at the higher level of the statistical significance in the group with the largest and middle large neurons giving the evidence about the greater sensitivity to the oxygen shortage in comparison with the group of the smallest spinal ganglion nerve cells.

Animals↗