Biomedical subjects

S Mukai

Publications and source records attributed to S Mukai.

182 records · Page 11Linked to original sources

PubMedDate not supplied

Meloxicam inhibits the growth of non-small cell lung cancer.

Cyclooxygenase (COX)-2 has been reported to play an important role in carcinogenesis. Meloxicam (preferential COX-2 inhibitor) inhibits the growth of COX-2 positive and COX-1 negative colorectal cancer cells. We evaluated the effects of meloxicam on the growth of lung cancer cells. By reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blot analysis, COX-2 but not COX-1 was expressed in human non-small cell lung cancer (NSCLC) cell lines (A549 and PC14). In human small cell lung cancer (SCLC) cell line (H841), both COX-1 and COX-2 were not detected. MTT assay and prostaglandin (PG) E2 enzyme immunoassay showed that meloxicam inhibited the growth and PGE2 production of both A549 and PC14, but not H841 cells. These findings suggest that COX-2 may play an important role in the pathogenesis and progression of NSCLC, and that meloxicam may be a useful therapeutic agents in the treatment of NSCLC.

Antineoplastic Agents↗

PubMedDate not supplied

Location of the femoral head in developmental dysplasia of the hip: three-dimensional evaluation by means of magnetic resonance image.

By using magnetic resonance imaging, we analyzed the position of the femoral head in 21 hips of 21 infants with developmental dislocation. The femoral head changed its location according to the hip position. In type A dislocation, the head was anterior to the acetabulum when the hip was extended, and it was posterior when the hip was flexed. There was wide contact area between the femoral head and the acetabulum in any hip position. In type B, the head was on the rim of the acetabulum when the hip was extended. When the hip was flexed, the head was on the posterior rim of the acetabulum, and there was no contact between the femoral head and acetabular cartilage. Some heads slipped into the socket with a click phenomenon when the hip was flexed/abducted. In type C dislocation, the head was on the edge of the acetabulum when the hip was extended. When the hip was flexed, the head moved posteriorly, and it was completely out of the socket.

Acetabulum↗