Biomedical subjects
Publications and source records attributed to S Mullen.
Veterinarians and dog breeders should work together to establish protocols for health care and breeding management that are based on sound scientific principles as well as practical systems. These protocols should involve bitches, stud dogs, and puppies. Tantamount importance must be placed on record keeping so that problems may be identified and solved before they are irreversible.
Diabetic neuropathy is probably the most frequent of the chronic complications of diabetes, and is usually found in association with diabetic retinopathy and/or nephropathy. We report seven patients with long-standing insulin-dependent diabetes mellitus in whom symptomatic peripheral neuropathy was the first and only documented complication. The diagnosis of peripheral symmetrical neuropathy was based on the presence of symptoms and abnormal physical findings, confirmed with abnormal electrophysiological and/or vibratory and thermal threshold measurements. Diabetic retinopathy and nephropathy were absent. We conclude that in some type 1 insulin-dependent diabetic patients, similar to what has been reported in type 2 non-insulin-dependent diabetes, peripheral neuropathy may be the first chronic complication to become manifest. This observation provides additional evidence to suggest that each of the diabetic complications may have a different pathogenic mechanism.
We used isolated ventricular myocytes to study 45Ca2+ transport in the presence of three concentrations of ouabain (10 nM, 1 microM, and 100 microM) in Tyrode solution containing 1 mM CaCl2. The cells were quiescent and during 45Ca2+ uptake and 45Ca2+ efflux experiments, 10 nM ouabain decreased Ca2+ content, 1 microM, didn't change it appreciably, and 100 microM increased it significantly. Qualitatively, the same results were obtained at 22 degrees C and 35 degrees C. Ouabain did not significantly affect the electrical activity of isolated, electrically stimulated myocytes, but it increased the amplitude of shortenings of these myocytes in a dose-dependent manner. Thus, the positive inotropic effect of ouabain at therapeutic doses (less than or equal to 10 nM) occurs in spite of decreased Ca2+ content, while at high toxic doses the positive inotropic effect is accompanied by an increment in Ca2+ content. These data support the hypothesis that the mechanisms of positive inotropy of ouabain are different at therapeutic and toxic concentrations of this drug. Finally, our study demonstrates that the effects of low doses of ouabain are independent of the release of endogenous catecholamines.
A device is described for comprehensively measuring the capability of human operators to detect and react to visual signals occurring at a variety of locations throughout the functional visual field. The system is completely automated and computerized, and provides both documentation files and descriptive graphics of the operator's performance immediately upon completion of testing. Sensitivity of detection can be measured for red, yellow, and green stimulus colors in a testing configuration which mimics commonplace surveillance of the ordinary viewing field. An abbreviated listing of the main operating program software is provided.
The 1977 CAP Comprehensive Blood Bank Survey was sent to 2487 laboratories in the United States and five foreign countries. The results show that ABO and Rh testing has a continued concurrence of greater than 94.8% between participating and referee laboratories, while antibody detection was 95.9% effective on the type problem normally encountered in a transfusion service. Cross match showed a concurrence rate of 97.3% or better. Although these testings are artificial and cannot be directly extrapolated into effectiveness of patient care, they can be compared with each other and show a standard of excellency in the laboratory which is a good or better than that found in previous studies. A series of ungraded specimens and questionnaires shows that most laboratories used a 51 degree C heat elution method for antibody elution, but slightly better results were obtained with the Rubin technic. A second study showed that the grading of a positive direct antiglobulin test was fairly reproducible throughout the country.
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