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Biomedical subjects

S Murthy

Publications and source records attributed to S Murthy.

111 records · Page 7Linked to original sources
PubMedDate not supplied

Treatment of chronic lymphocytic leukemia with an anti-idiotypic monoclonal antibody.

A monoclonal antibody (H-99) was prepared that reacts specifically with the leukemia cells from a patient with stage IV chronic lymphocytic leukemia of B-cell origin. Escalating doses of the antibody were administered to the patient in two courses of therapy. The first course did not result in any significant change in total lymphocyte count; however, the platelet count (which was initially abnormal) rose steadily during treatment to a level greater than 250,000 per mm3. A second course of treatment was begun approximately three months after the first course, and the protocol was modified to consist of five doses of antibody given over a 10-day period, with the highest dose being 500 mg per day. The second course of treatment did not result in any change in total lymphocyte or platelet levels, and there was no significant toxicity associated with the treatment. The failure to induce an anti-tumor response in the patient was probably related to the large concentration (approximately 400 micrograms/mL) of free serum idiotype in addition to the severely compromised immune system of the patient at the time of treatment.

Antibodies, Monoclonal↗
PubMedDate not supplied

Influencing spermicide use among low-income minority women.

Spermicides reduce the risk of a variety of sexually transmitted diseases (STDs) and hold promise for reducing the risk of human immunodeficiency virus (HIV) transmission. Many high-risk women are unaware that they are at risk for STDs and are unfamiliar with spermicides, however. A program promoting spermicides for the prevention of STDs was tested in a controlled intervention among low-income minority women seeking services in a public health family planning clinic. Women exposed to the intervention had more positive attitudes toward spermicides and used spermicides more than three times as often, on average, as control subjects. The best predictor of spermicide/condom use was knowledge of how to use spermicides correctly (OR 3.2, 95% CI 2.0, 5.0). Fear of acquired immune deficiency syndrome (AIDS) or STDs did not predict spermicide use. This study demonstrates that brief interventions in waiting areas of public health clinics can have a significant impact in helping women protect themselves from HIV and STDs.

Female↗