PubMed Health⌕ Search

Biomedical subjects

S N Becker

Publications and source records attributed to S N Becker.

18 recordsLinked to original sources
PubMed1987

Experience with pelvic washings in stage I and II endometrial carcinoma.

Pelvic washings for cytologic analysis have become an accepted diagnostic procedure in the management of endometrial carcinoma. A retrospective study was performed in 163 consecutive patients with FIGO Stage I and II endometrial carcinoma to assess the significance and value of the washings. Abnormal results were obtained in 5.5% of patients. Patients with FIGO grade 3 lesions were significantly most likely to have abnormal washings (P less than 0.05). Significant association was not observed with stage, depth of myometrial invasion, extrauterine spread, histologic subtype, prior hormone usage, or hormone receptor status. Multivariant analysis indicated that, for Stages I and II combined and for Stage I alone, FIGO grade 3 was most predictive of poor survival (P less than 0.01). The postoperative therapy of only 2 patients (1.2%) was altered by the results of the pelvic washings and only one of these patients has survived. No patients have had recurrent disease (median follow-up 31 months) in the peritoneal cavity with negative washings unless two or more other adverse prognostic factors were present. It is concluded that pelvic washings have a limited role in the clinical management of Stage I and II endometrial carcinoma.

Carcinoma↗
PubMed1982

Bladder reconstruction in rabbits with glutaraldehyde-stabilized amniotic membranes.

Glutaraldehyde-treated human amniotic membranes were used to repair rabbit bladders after supratrigonal cystectomies. The membranes maintained the integrity of the bladders until healing and reepithelialization occurred. There was no significant loss of bladder capacity or decreased renal function postoperatively. Calcification did not occur on the membranes but was noted on chromic sutures retaining the membranes in 7 of 27 bladders. These findings suggest that glutaraldehyde-stabilized amnion is well tolerated by the urothelium and may serve as a suitable material for replacement of genitourinary tissues.

Amnion↗
PubMed1982

Specific red cell adherence test applied to tumors of ureter and renal pelvis.

The specific red cell adherence (SRCA) test used previously as a prognostic indicator of bladder tumors was used in a retrospective review of 14 patients with transitional cell carcinoma of the ureter and renal pelvis. SRCA-positive individuals appear to have better survival and progress less frequently to metastatic disease. Of five patients with positive reactions, none had distant metastases. Conversely, in SRCA-negative individuals metastatic disease developed more frequently (4 of 9). The SRCA test can be as useful a test of the prognosis of ureteral and renal pelvis tumors as it is of urinary bladder tumors.

Adult↗
PubMed1982

Cone biopsy during pregnancy.

Under a diagnostic schema that used cervical conization liberally for evaluating women with abnormal Papanicolaou smears, 82 pregnant patients underwent conization. Fifteen had significant morbidity related to cervical bleeding. The uncorrected perinatal mortality was 44.1/1000. Sixty-one cone biopsies, performed before colposcopy was introduced into the schema, uncovered 2 cases of previously undiagnosed invasive carcinoma. Among 21 patients who underwent colposcopy before conization, 1 case of microinvasive carcinoma was diagnosed. During the study, 15 patients with frankly invasive carcinoma were identified, 9 by punch biopsy of a gross lesion, 2 by cone biopsy without prior colposcopy, and 4 by colposcopically directed punch biopsy. As a result of the review, the diagnostic schema has been changed so that biopsy is used less often on pregnancy patients.

Biopsy↗
PubMed1980

Dystocia, consumptive coagulopathy, and cardiac failure as complications of a congenital benign mesenchymoma.

A congenital benign mesenchymoma which arose in the right foot resulted in dystocia. Shortly after birth, high-output cardiac failure developed secondary to abnormal shunting in the extensive irregular vasculature. Consumptive coagulopathy also occurred, believed to be the result of widely dilated abnormal vessels and extensive necrosis secondary to the trauma of the dystocia. These problems disappeared after resection of the tumor; there has been no recurrence after 2 years.

Blood Coagulation Disorders↗
PubMed1979

Correlation between macrophage intracellular electrical potentials and malignant melanoma growth in a murine model.

Peritoneal macrophages were collected from mice at varying periods after transplantation of an allogeneic malignant melanoma in the hind limb. The intracellular electrical potentials of these macrophages were measured and a correlation was found to exist between tumor growth measured by size and pathological examination, and the development of large negative intracellular potentials. We propose that this change in intracellular potential is correlated with changes in the immune system and may be triggered by membrane permeability changes possibly in response to calcium ions.

Animals↗
PubMed1978

Benign gastric ulcer in a patient with betazole-fast achlorhydria.

We report a case of benign gastric ulcer that occurred in a 50-year-old man with betazole hydrochloride-fast achlorhydria. The rarity of exceptions to the rule that ulcers in achlorhydric stomachs are malignant (to our knowledge, this is only the sixth reported case) confirms the wisdom of regarding such ulcers as malignant until proved unequivocally to be benign.

Achlorhydria↗
PubMed1975

Pericardial effusion secondary to mucoepidermoid carcinoma of the parotid gland. A report of an unusual case.

This paper reports a unique case of malignant pericardial effusion secondary to metastatic mucoepidermoid carcinoma in a patient who previously had mucoepidermoid carcinoma of the parotid gland and subsequently was found to have a hypernephroma of the kidney. Its distinctive features warranted the diagnosis of mucoepidermoid carcinoma as the cause of the effusion, and excluded the more aggressive hypernephroma. Although pericardectomy was ultimately necessary, there was no evidence of viable malignancy in fluid specimens obtained after an initial course of radiation therapy or in the resected pericardium. This suggests that conservative treatment with local radiation therapy might be successful in future cases of pericardial effusion in this malignancy.

Adenocarcinoma↗
PubMedDate not supplied

Bizarre atypia in gastric brushings associated with hepatic arterial infusion chemotherapy.

Hepatic arterial infusion chemotherapy (HAIC) for unresectable hepatic neoplasms has been associated with gastric ulcers and epithelial atypia that may be misinterpreted as carcinoma. Gastric brushings were reviewed from six patients who developed gastric ulcers with histologically proven atypia following HAIC. Marked cytologic atypia, reminiscent of a pronounced radiation effect, was present in gastric epithelial cells in five patients. The atypical cells occurred singly or in small sheets. They were markedly enlarged but a low nuclear-cytoplasmic ratio was preserved. The abundant cytoplasm was vacuolated or foamy. Binucleation and multinucleation were common, and massive nucleoli were characteristic. The brushings also contained the reparative, inflammatory and necrotic changes associated with usual benign gastric ulcers. The bizarre atypia associated with HAIC can be a source of misdiagnosis of cancer in cytologic as well as in histologic specimens.

Adult↗
PubMedDate not supplied

Scanning electron microscopy of alcohol-fixed cytopathology specimens.

Cells in specimens fixed in alcohol and stained by the Papanicolaou method for routine cytodiagnosis were subsequently studied by scanning electron microscopy (SEM) to determine if they manifested topologic features described in specimens prepared for optimal SEM observation. In normal bronchial washings, ciliated columnar cells were obvious, and microridges were detected in several squamous cells. Microvilli, although sometimes coarse and blunted, were present in cells of adenocarcinoma, squamous carcinoma and malignant mesothelioma in fluid specimens. Benign histiocytes in bronchial washings, neuroblastoma cells in a smear of bone marrow aspirate and lymphocytic lymphoma cells in spinal fluid had ruffled surfaces. Should topologic features prove to be diagnostically significant, SEM may be of value in further studying equivocal specimens even though they were previously prepared for routine light microscopic observation.

Adenocarcinoma, Bronchiolo-Alveolar↗
PubMedDate not supplied

Detection of endometrial stromal sarcoma in cervicovaginal smears: reports of three cases.

Although the small neoplastic cells of pure endometrial stomal sarcoma do not usually exfoliate readily, they are sometimes detected in cervicovaginal smears. In three cases, constituting half the patients with histologically confirmed endometrial stromal sarcoma from 1971 through 1979 at the University of Texas Medical Branch at Galveston, cervicovaginal smears also contained malignant or suspicious cells. All three had certain common features: mostly rounded, small malignant cells with occasional tapered "comet" forms, discernible nucleoli and a tumor diathesis.

Adult↗
PubMedDate not supplied

Enterobius vermicularis ova in routine cervicovaginal smears. Light and scanning electron microscopic observations.

From 1971 through 1980, four Papanicolaou smears containing pinworm (Enterobius vermicularis) eggs were found among approximately 220,000 routine smears examined at the University of Texas Medical Branch at Galveston. The highest number of ova counted on one slide was 420. Typical light microscopic features of the eggs included elongated oval shapes with flattening of the ventral sides and double-contoured shells folded at one end. The background in three smears showed massive acute inflammation. A scanning electron microscope study of one case revealed that the ova had a relatively smooth surface with an invaginated area at one end.

Adult↗