[Characterization of a control group for evaluation of the effectiveness of treatment of patients with osteogenic sarcoma].
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Biomedical subjects
Publications and source records attributed to S N Ivanenko.
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A rare soft tissue tumour--chordoid sarcoma of the thigh--in a 52-year-old woman is described. The tumour has a specific histologic structure and resembles a true chordoma. The most frequent site of chordoid sarcoma is the limb soft tissue that is in a direct link with fasciae, tendon sheaths and synovial membranes.
The content of acid mucopolysaccharides of the interstitial matrix of various structural variants of chondrosarcoma was studied in the operation material of 28 chondrosarcomas. The chondrosarcoma tissue contained a large amount of sulphated mucopolysacharides and a low amount of hialuronic acid. The quantity and quality of mucopolysaccharides directly depended on the degree of maturity of the tumour tissue which was reflected morphologically in the scarcity of intercellular substance in the tissue.
The association between histological structure of chondrosarcomas and their clinical course was studied on the material of 138 clinico-morphological observations. The scheme of O'Neal and Ackerman extended and supplemented by S. I. Lipkin was used to determine the degree of morphological maturity of chondrosarcomas. By the degree of maturity the tumours were divided into 3 groups. No relationship between the rate of recurrence and the degree of maturity was observed. On the contrary, the dependence of metastasizing on the maturity of tumor was statistically significant. Difference in the survival among patients with chondrosarcomas of the I, II, and III degree of maturity was quite significant, particularly in the period of 5-9 years after the establishment of the diagnosis and surgical treatment.