PubMed Health⌕ Search

Biomedical subjects

S N Joffe

Publications and source records attributed to S N Joffe.

At least 127 records · Page 7Linked to original sources
PubMed1977

Amylase creatinine clearance ratio after biliary surgery.

The amylase creatinine clearance ratio (ACCR) is considered to be a more sensitive index of acute pancreatitis than the serum amylase level. Serial ACCR estimations were undertaken in 25 patients undergoing an elective cholecystectomy. Using accepted criteria, 28% of these patients developed, in the postoperative period, biochemical evidence of pancreatic gland damage, although the serum amylase level remained normal. This raised ACCR was particularly noted in patients who had undergone an exploration of the common bile duct. The ACCR would appear to be a more sensitive index of pancreatic gland disruption secondary to biliary surgery than the serum amylase level.

Acute Disease↗
PubMed1977

Gastrin, antral g cells, and gastric acid in secretagogue-induced and antihistamine-inhibited duodenal ulcers.

In fasting control rats there was continuous basal gastric acid secretion, with a low plasma gastrin and antral G-cells full or immunofluroescent gastrin. After subcutaneous infusion of the gastric secretagogues, pentagastrin + carbachol, there was a six-hour period of gastric hypersecretion, but no change in plasma and G-cell gastrin. Pretreatment with the antihistamine derivative, Pfizer UK-9040, decreased both basal and stimulated acid secretion, whereas plasma gastrin levels increased and the antral G-cells were emptied of gastrin. These results suggest that this antihistamine derivative decreases gastric acid secretion by a direct action on the parietal cells and not by reducing gastrin release from the G-cells. The increased release of gastrin from the G-cells may be secondary to decreased gastric acid production, or more probably by a direct stimulation of the antral G-cells.

Animals↗
PubMed1977

The effect of GIH and Boots secretin and cholecystokinin on duodenal ulcers in the rat.

The effects of two commercially available preparations of secretin and cholecystokinin have been studied on experimental duodenal ulcers in the rat. Pentagastrin and carbachol infused subcutaneously over 24 hours produced a 100% incidence of duodenal ulcers. A dose-related inhibition of these ulcers was found using secretin obtained from the Gastrointestinal Hormone Laboratory, Stockholm (GIH). Boots secretin had no such inhibitory action and may even have aggravated the duodenal ulcerogenesis. Similar results were obtained with both GIH cholecystokinin and Boots pancreozymin.

Animals↗
PubMed1976

Endoscopy and routine and double-contrast barium meal in diagnosis of gastric and duodenal disorders.

A double-contrast barium meal has been carried out on 37 patients in whom there had been disagreement in diagnosis between the routine barium meal and subsequent oesophago-gastro-duodenoscopy. There was an 81% agreement between the endoscopic diagnosis and the diagnosis obtained with double-contrast barium meal. Confirmation of the endoscopic and double-contrast radiological diagnosis was obtained all 11 patients who had surgical treatment. These findings suggest that a double-contrast barium meal should be routinely used in the diagnosis of dyspepsia.

Barium Sulfate↗
PubMed1976

Postoperative deep vein thrombosis in otolaryngologic surgery.

The aim of this study was to determine the incidence of postoperative deep vein thrombosis in otolaryngologic surgery. The diagnosis was made by clinical examination, a method using fibrinogen labeled with radioactive iodine (125I), and the Doppler ultrasound technique. Only one (11%) patient developed an asymptomatic deep vein thrombosis. This is in contrast to the incidence in general surgical patients, which varies between 28% and 51%. The difference was probably related to the minimal tissue trauma and early mobilization of the otolaryngologic patients.

Doppler Effect↗
PubMed1976

Prevention of secretagogue-induced ulcers in the rat.

An inhibitor of gastric secretion, Pfizer UK -9040, a derivative of the antihistamine triprolidine, was given orally 50 to 100 mg per kg 1 hr before and at various times during a 24-hr subcutanwous infusion of ulcerogenic secretagogues. The higher the dose and the more frequent the dosage, the lower was the incidence, severity, number, and perforations of duodenal ulcers. The mechanisms by which UK -9040 prevents these ulcers is probably inhibition of gastric secretion.

Animals↗
PubMed1975

The prevention of postoperative deep vein thrombosis.

Numerous recent reports have appeared dealing with the prevention of postoperative deep vein thrombosis. Simple mechanical measures are inadequate, electrical stimulation has complications, but the motorised foot mover and pneumatic compression appear effective. Drugs such as coumadin, aspirin and dipyridamole are ineffective, but dextran and sodium pentosan polysulphate appear to have a place. However, if the efficacy and safety of low-dose subcutaneous heparin is statistically confirmed in a multicentre trial, it may lead to the elimination of the morbidity and mortality of postoperative thrombo-embolism.

Adult↗
PubMed1975

Incidence of postoperative deep vein thrombosis in neurosurgical patients.

This preliminary report on the use of 123I-fibrinogen and Doppler ultrasound techniques for the diagnosis of postoperative deep vein thrombosis (DVT), shows that neurosurgical patients are at considerable risk. The DVT was often asymptomatic, bilateral, and extended into the more proximal veins.

Craniotomy↗