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Biomedical subjects

S N Mishra

Publications and source records attributed to S N Mishra.

At least 19 recordsLinked to original sources
PubMed2000

Accumulation of lead and cadmium in upper parts of mustard (Brassica juncea) seedlings in response to putrescine.

Lead and cadmium accumulation examined in shoot and leaf tissues of seedlings of mustard (Brassica juncea cv RH-30), at 7th day, treated with either putrescine (1 mM), or ammonium nitrate (10 mM) or IAA (10 microM). These were included in the nutrient medium, containing Pb or Cd (0.1 mM and 2 mM). Metal accumulation was more in shoot than in leaf tissues, which was increased manifold under saline conditions. However, Cd accumulation in tissues was higher than Pb. Chemical (putrescine, ammonium nitrate or IAA) treatment of the seedlings, decreased metal accumulation in leaf (10-20%) and in shoot (40 to 60%) tissues, depending upon external metal levels. Putrescine significantly decreased the metal accumulation and translocation under saline conditions.

Brassica↗
PubMed1990

Cutaneous leishmaniasis in India. Clinical experience with itraconazole (R51 211 Janssen).

Fifteen patients with cutaneous leishmaniasis were randomly selected for clinical trials with itraconazole. A single daily itraconazole dose of approximately 4 mg per 1 kg of body weight was administered to each patient with breakfast for 6 weeks. Five patients served as controls. On completion of therapy, ten cases in the study group (66.6%) were considered to be cured. No major adverse effects were reported. No significant changes were seen in the controls at the end of the study. The possibility of spontaneous recovery will be discussed in this report even though it is considered to be unlikely. Itraconazole has promising potential in cutaneous leishmaniasis therapy.

Adolescent↗
PubMedDate not supplied

Profile of cardiac complications of snake bite.

The present study was conducted in 30 cases of snake bite to understand fully the intricacies of the cardiac profile and to render help in the management of the problem arising out of them. All were subjected to routine and specific investigations (ECG, X-ray Chest, SGOT). The present study concluded that 57 per cent of patients of snake bite were in 2nd and 3rd decades of life. Viperine snake bite occurred in 93 per cent and elapide snake bite in 7 per cent of cases. Cardiotoxicity was seen in only 25 per cent patients with viperine bite. Seventy-six per cent of the patients presented within 24 hours of the bite. Seventy per cent of patients had haemorrhagic manifestations and 30 per cent had cardiotoxicity. The disturbance in heart rate was seen in 47 per cent, rhythm disturbance in 6.7 per cent, tachycardia in 36.7 per cent and bradycardia in 10 per cent cases. Hypertension was found in 6.7 per cent, hypotension in 16.7 per cent. Thirty per cent of patients had gallop rhythm and it persisted in 16.6 per cent patients till discharge. One patient had evidence of pulmonary edema and one had basal congestion. Cardiomegaly on chest X-ray was found in one patient and elevated SGOT titres were found in ten per cent. Common electrocardiographic changes were sinus tachycardia, sinus arrhythmia (6.6%), sinus bradycardia (10%), tall T-wave in V2 (3.3%), pattern suggestive of acute anterior wall infarction with reciprocal changes (3.3%), myocardial ischemia (10%), non-specific ST-T changes (16.7%) and atrioventricular block (3.3%). The mortality rate was 10 per cent and all these patients had bleeding manifestations and abnormal electrocardiograms.

Adult↗