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Biomedical subjects

S N Naik

Publications and source records attributed to S N Naik.

At least 19 recordsLinked to original sources
PubMed2005

Optimization of alkali-catalyzed transesterification of Pongamia pinnata oil for production of biodiesel.

Studies were carried out on transesterification of Karanja oil with methanol for the production of biodiesel. The reaction parameters such as catalyst concentration, alcohol/oil molar ratio, temperature, and rate of mixing were optimized for production of Karanja oil methyl ester (KOME). The fatty acid methyl esters content in the reaction mixture were quantified by HPLC and 1H NMR method. The yield of methyl esters from Karanja oil under the optimal condition was 97-98%.

Biotechnology↗
PubMed2004

Larvicidal activity of Tagetes patula essential oil against three mosquito species.

Larvicidal activity of Tagetes patula essential oil was tested against the fourth instar larvae of Aedes aegypti, Anopheles stephensi, and Culex quinquefaciatus. Five different concentrations of essential oil were studied and the results were compared with that of synthetic insecticide, malathion. A. aegypti (LC(50) 13.57, LC(90) 37.91) was most susceptible followed by An. stephensi (LC(50) 12.08, LC(90) 57.62) and C. quinquefaciatus (LC(50) 22.33, LC(90) 71.89).

Animals↗
PubMed1990

Glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase activities in normal canine mammary gland and in mammary tumours and their correlation with oestrogen receptors.

Glucose-6-phosphate dehydrogenase (G-6-PD) and 6-phosphogluconate dehydrogenase (6-PGD) activities were studied in 10 normal canine mammary glands and in 19 canine mammary tumours, which included seven benign and 12 malignant neoplasms. The malignant tumours were also examined for oestradiol receptors. The mean G-6-PD and 6-PGD activities were 5.17 +/- 1.84 and 1.65 +/- 0.64 IU per g protein in normal glands, 8.8 +/- 2.7 and 3.8 +/- 0.99 IU per g protein in benign and 19.6 +/- 5.2 and 8.5 +/- 2.1 IU per g protein in malignant mammary tumours. The enzyme activities were significantly higher in tumour tissue than in normal glands. Malignant tumours had much greater activity than benign. With the increasing anaplasia, there was a corresponding rise in the activity of the two enzymes. There was an inverse correlation between the oestrogen receptor (ER) status and the enzyme activity. The ER-positive tumours had low and ER-negative tumours had high enzyme activities.

Animals↗
PubMed1990

Serum haptoglobin level in patients with malignant lymphoma and its clinical significance.

Serum haptoglobin level and its phenotypes were studied in 208 normal people and 176 malignant lymphoma patients consisting of 112 Non-Hodgkin's Lymphoma (NHL) and 64 Hodgkin's Disease (HD) at Tata Memorial Hospital, Bombay and were correlated with the clinical stages of the lymphomas. Haptoglobin (Hp) levels were also estimated in the patients at different intervals during their chemotherapy. Hp level was found significantly increased to 147.83 +/- 8.67 in NHL and 173.57 +/- 13.31 in HD as compared to 67.46 +/- 2.53 in the controls. The phenotypic and gene frequencies in the lymphoma patients did not differ significantly from those of the controls. All the clinical stages, except stage I, of NHL and HD revealed significant rise in Hp level when compared with the controls. When different clinical stages of NHL and HD were compared separately, HD showed significant rise in HP level over the NHL only in Stage IV (p less than 0.05). Significant reduction in Hp level was observed when the disease regressed due to chemotherapy but it again increased with the relapse of the disease. Thus, the study of serum haptoglobin levels at intervals in lymphoma patients would help to understand the regression or relapse of the disease and also the prognosis.

Haptoglobins↗
PubMed1989

Comparative pathology of canine mammary tumours.

The pathological features of 52 canine mammary tumours were studied and compared with those of human breast neoplasms. In many of the former, the constituent cells were both epithelial and myoepithelial. Cartilaginous and osseous metaplasia of the stromal tissue was striking in a few tumours. Carcinosarcomas were also encountered. On a careful search, virus-like particles were observed in five tumours. The similarities and differences between the human and canine mammary tumours were discussed with a view to assessing the suitability of dog mammary tumour as an animal model for human breast tumours.

Adenoma↗
PubMed1987

Receptors for epidermal growth factor and estradiol in canine mammary tumors.

Both growth factors and steroid hormones are known to be associated with breast cancer. We have studied the epidermal growth factor receptor (EGFR) in canine mammary tumors and have shown the presence of a single class of 125I-EGF binding receptor sites in 9 out of 13 (70%) tumors, using Scatchard plot. The dissociation constant (KD) was 10(-9)M. An inverse correlation between EGFR and estrogen receptor (ER) was observed in 54% of the tumors. Our data suggest that EGFR might be used as a biochemical marker in canine mammary tumors.

Animals↗
PubMed1984

A new glucose-6-phosphate dehydrogenase variant (G-6-PD Kalyan) found in a Koli family.

A new Indian variant of erythrocytic glucose-6-phosphate dehydrogenase (G-6-PD) has been detected in a Koli male subject during population genetic studies. The enzyme variant is characterized by mild enzyme deficiency, slow electrophoretic mobility, low Km for G-6-P, increased utilization of substrate analogues, heat instability and a normal pH optimum curve. From these results this was considered to be a new variant and was designated G-6-PD Kalyan. The family history and routine hematological studies did not reveal any evidence that the G-6-PD Kalyan is associated with any hematological abnormalities or clinical symptoms.

Electrophoresis, Starch Gel↗
PubMed1979

Haemoglobin variants in mice.

Haemoglobin variants were studied in wild and laboratory house mice (Mus musculus), including standard and new inbred strains, using starch-gel electrophoretic technique. Single (Hbbs) or diffuse (Hbbd) types of haemoglobin were found in all of them. The embryonic haemoglobin pattern was different from although similar to that of the adult in all the strains. The haemoglobins revealed monomorphism in the inbred strains, while polymorphism was observed in non-inbred laboratory and wild mice.

Animals↗