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Biomedical subjects

S N Rasmussen

Publications and source records attributed to S N Rasmussen.

At least 145 records · Page 8Linked to original sources
PubMed1977

Leucocyte migration test with autologous colonic mucosa as antigen in patients with ulcerative colitis.

The leucocyte migration agarose technique (LMAT) was applied in a study of the migration of peripheral leucocytes in 16 patients with ulcerative colitis using three different autologous types of tissue as antigen: rectal mucosa, skin and buccal mucosa. In all cases the migration indices were within normal limits, and they did not differ from a group of control patients suffering from peptic ulcer, irritable colon, or haemorrhoidal tumours. The present study does not support the theory of cellular hypersensitivity against colonic mucosa in patients with ulcerative colitis.

Antigens↗
PubMed1976

The extravascular pool of albumin in the non-diuretic rat kidney estimated by means of radioactive tracers and quantitative immunochemistry.

The extravascular pool of albumin in the non-diuretic rat kidney was determined as the difference between total and intravascular albumin pools. The total pool of albumin was determined in two ways in the same kideny: 1. as the distribution volume of rat endogenous albumin measured immunochemically and 2. as the distribution volume of 125I-labelled rat albumin equilibrated for 4 days. The distribution volume of 131I human albumin after 1 min equilibration was taken as a measure of the intravascular pool. Total albumin pool estimated as rat endogenous albumin volume of distribution averaged 13.4, 25.1, and 43.0 mul per 100 mg tissue in cortex, outer and inner medulla, respectively. Similar figures were obtained using 125I-labelled rat albumin. Intravascular pool of albumin in the 3 zones averaged 7.2, 19.7, and 26.8 mul per 100 mg tissue. The calculated extravascular fraction of albumin averaged 0.44, 0.21, and 0.35 for cortex, outer and inner medulla, respectively.

Albumins↗
PubMed1976

The treatment of thyroid cysts by ultrasonically guided fine needle aspiration.

28 solitary thyroid cysts diagnosed by ultrasonic examination were punctured under guidance of ultrasound, as a therapeutic trial and for cytological evaluation. No case of malignancy was encountered. At follow-up 3--6 months later no cyst could be demonstrated in 20%, 30% of the cysts had decreased, while 50% were unchanged or increased in size.

Biopsy, Needle↗
PubMed1975

Effects of antidiuretic hormone on intrarenal red cell and plasma volumes in the water diuretic rat.

The intrarenal distribution of 51Cr-labelled red cells and 125I-immunoglobulin M (125I-IgM) was studied in water diuretic control rats and in water diuretic rats infused with argenine vasopressin (ADH) 1 muU per minute and gram rat. The IgM volume after 1 min equilibration time was taken to be a measure of plasma volume. Intrarenal haematocrits were calculated from the red cell and plasma volumes and were expressed as fractions of total body haematocrit. Infusion of ADH provoked a rise in urine osmolality from below 200 to values ranging from 800 to 2000 mosm per kg with only insignificant elevation of arterial blood pressure. Calculated red cell volume was significantly increased in all renal zones whereas calculated regional plasma volumes were not significantly changed by ADH. In all renal zones ADH administration thus involved significant increments in haematocrit; the relative increment was most pronounced in the inner medulla. The results give no direct evidence in favour of or against vasoconstrictive effects of ADH in the rat kidney. However, it may be argued that the haematocrit changes are compatible with increased haemodynamic resistance and reduction of blood flow in all renal zones (especially in the medulla) involving decreased linear velocities and less pronounced tendency to axial accumulation of red cells. ADH may increase haemodynamic resistance in two ways, first by acting as a vasoconstrictor and, second, by indirectly increasing blood viscosity in the medulla by increasing tissue osmolality.

Animals↗
PubMed1975

Intrarenal distribution of albumin and immunoglobulin M in the non-diuretic-rat.

The intrarenal distribution of 125I-immunoglobulin M (125I-IgM) and 131I-albumin was studied in non-diuretic rats. Tracer equilibration times of 1, 10 and 60 min were used. In the 1 min series, in all renal zones (cortex, outer and inner medulla) the albumin volumes did not differ significantly from those of the much larger molecule, IgM. The 1 min values were found to be 9, 6, 17, and 24 mul per 100 mg tissue for whole kidney, cortex, outer and inner medulla, respectively. In the 10 and 60 min series the cortical albumin and IgM volumes did not differ significantly either, while in the medulla the albumin volumes slightly exceeded the IgM volumes. The 10 min values did not differ significantly from the corresponding 1 min values, except that in the cortex the albumin value was higher at 10 than at 1 min. All 60 min values were significantly higher than the corresponding 1 min values. In the medullary zones these differences can be explained for the most part as caused by accumulation of free radioiodide. In the cortex free radioiodide plays a minor role and the 60 min distribution volumes of both proteins (whether corrected for free radioiodide or not) exceed the 1 min volumes by some 50 per cent. The 1 min values can be taken to represent the intravascular compartment; the 60 min values include the extravascular compartment. In conclusion, the present study indicates that: 1. The extravascular pool of albumin constitutes only a minor fraction of the total intrarenal pool-in the cortex about one third. 2. The equilibration of tracer proteins (IgM or albumin) between plasma and the extravascular compartments of the kidney is a rather slow process; the results are compatible with a mean transit time of tracer albumin from plasma to lymph of 26.5 min, as found by others [19]. 3. Extravasation of IgM and albumin most likely takes place via large vescicles or "big leaks".

Albumins↗
PubMed1975

Characteristics of rat jejunal transport of tryptophan.

The parameters of rat jejunal transport of tryptophan have been examined. The interactions between tryptophan and lysine or methionine have been reexamined, and some aspects of the trans effects of cellularly accumulates amino acids have been studied. It has been demonstrated that: (1) The influx of tryptophan across the jejunal brush border (Jmc-Trp) can be accounted for by the carrier of alpha-aminomonocarboxylic acids alone. (2) Tryptophan competes with lysine for the carrier of basic amino acids across the brush border membrane without itself being transported by this carrier. (3) Lysine has neither cis nor trans effects on Jmc-Trp, whereas intracellular tryptophan is highly inhibitory to Jmd-Lys. (4) The intracellular concentration of lysine and of tryptophan, [Lys]c and [Trp]c, are unaffected by tryptophan and lysine, respectively, although the transmural fluxes, from the mucosal side to the serosal side, Jms, of lysine, Jms-Lys, and of tryptophan, Jms-Trp, are inhibited by tryptophan and lysine, respectively. The latter effects thus represent inhibitory interactions at the basolateral membrane. (5) Methionine is a potent cis and transinhibitor of Jmc-Trp, but stimulated Jms-Trp and reduces [Trp]c. (6) Methionine causes trans acceleration of the influx of lysine across the brush border membrane, Jmc-Lys, but has no effect on the influx of galactose, Jmc-Gal. (7) Leucine causes trans inhibition of Jmc-Leu. (8) Tryptophan does not cause cis inhibition of Jmc-Gal, but is a strongtransinhibitor of Jmc-Gal. (9) Cellularly accumulated tryptophan appears to accelerate the eventual decline in transepithelial potential difference and short-circuit current. These results are consistent with the conclusions that: (1) Tryptophan is transported across the brush border membrane by the carrier of neutral amino acids alone, but leaves the cell across the basolateral membrane by a mechanism used by lysine also. (2) Leucine, methionine and probably tryptophan have a transeffect on the transport of neutral amino acids across the brush border membrane which may represent a phenomenon which can appropriately be termed decelerating exchange diffusion. (3) Cellularly accumulated tryptophan has a strong and indiscriminate depressive effect on all transport functions of rat jejunal epithelium.

Animals↗
PubMed1975

Liver volume estimated by ultrasonic scanning before and after portal decompression surgery.

In 12 patients with cirrhosis of the liver, determination of the liver volume by ultrasonic scanning and of the galactose elimination capacity (GE) were made before and after portal decompression surgery. The liver volume decreased significantly, with a median decrease of 402 ml (psmaller than 0.01). Also the GE decreased, but relatively less than the liver volume, so that the calculated GE per unit liver volume increased, with a median increase of 5 mg per minute times 100 ml liver volume (psmaller than 0.005). The decrease in liver volume following portal decompression is assumed to be due in part to reduction of liver blood volume, in part to loss of tissue water and fat, and probably to some loss of parenchyma, accounting for a reduction of the GE.

Adult↗
PubMed1975

Detection of thyroid cysts by ultrasonic examination.

Ultrasonic examination of 80 thyroid nodules was carried out in order to detect fluid-filled lesions of the gland. The results of preoperative ultrasonic examinations were compared with the findings at surgery. For the ultrasonic diagnosis "cyst", a predictive value of 88% was calculated. It is concluded that ultrasonic examination represents a reliable tool for the detection of thyroid cysts.

Cysts↗