PubMed Health⌕ Search

Biomedical subjects

S N Udintsev

Publications and source records attributed to S N Udintsev.

15 recordsLinked to original sources
PubMed1992

[The enhancement of the efficacy of adriamycin by using hepatoprotectors of plant origin in metastases of Ehrlich's adenocarcinoma to the liver in mice].

It was shown that the use of an anthracycline antibiotic--adriamycin in mice with metastatic involvement resulted in pronounced liver dysfunction, as suggested by a sharp increase in blood transaminase levels. In the same model, a hepatoprotector of plant origin--Rhodiola rosea extract--was shown to inhibit tumor dissemination. Combined application of adriamycin and the extract proved no inferior in terms of antimetastatic efficacy and nearly free from toxicity.

Animals↗
PubMed1991

[Correction by natural adaptogens of hormonal-metabolic status disorders in rats during the development of adaptation syndrome using functional tests with dexamethasone and ACTH].

Rats exposed to stress by fixation develop a complex of hormonal metabolic homeostasis disturbances (as evidenced by changed levels of ACTH, insulin, 11-HOCS, urea, glucose). One of the major mechanisms of these disorders in reduced hypothalamus sensitivity to regulatory signals and exhausted adrenocortical functional activity, developing at the stages of anxiety and exhaustion of the adaptation syndrome, respectively, and detectable by functional tests with dexamethasone and ACTH. Administration of natural adaptogens (Scutellaria baicalensis extract and its active principle, baikalin flavonoid) was conducive to normalization of the majority of the examined parameters whatever the direction of changes.

Adaptation, Physiological↗
PubMed1991

The role of humoral factors of regenerating liver in the development of experimental tumors and the effect of Rhodiola rosea extract on this process.

In experiment on rats with Pliss lymphosarcoma (PLS) it was shown that partial hepatectomy (PHE), a course application of Rhodiola rosea extract (RRE) or combined effects inhibit the growth of tumors by 37, 39 and 59%, respectively, and that of metastases by 42, 50 and 75%. In combined treatment the process of hepatic regeneration was completed in earlier terms versus the animals which underwent PHE, and proliferative activity of the tumor and metastases decreased by 15 and 59%, respectively, judging by the degree of 3H-thymidine incorporation into DNA of these tissues. The assessment of clonogenic activity of PLS cells taken in the animals of this group, using the method of diffusion chambers, revealed a significant decrease in this index versus the rats which underwent PHE or which were given RRE (number of colonies per chamber being 4.8 +/- 0.5; 8.6 +/- 0.9; 5.7 +/- 0.6, respectively; in control 13.8 +/- 1.5). The assumption that these effects are determined by factors originating from the regenerating liver was confirmed in experiments with double-layer agar systems. Inhibition of colony-forming activity of PLS cells was the maximum in application of the hepatocytes of the rats which underwent a complex of effects, as a feeder, versus the hepatocytes taken in intact or hepatectomized animals, or the rats which were given RRE (number of colonies per plate well being 4.6 +/- 0.3; 15.7 +/- 1.6; 7.4 +/- 0.8; 8.7 +/- 0.9, respectively; in the control 25.6 +/- 6.5). In experiments on mice with Ehrlich adenocarcinoma, the factors isolated from the liver of animals subjected to PHE against a background of RRE administration and from the liver of mice which were given RRE only, as well as operated or intact ones, inhibited the tumor growth to 63, 38, 35 and 21%, respectively.

Adenocarcinoma↗
PubMed1990

[Changes in clonogenic properties of bone marrow and transplantable mice tumor cells during combined use of cyclophosphane and biological response modifiers of adaptogenic origin].

The clonogenic activity of tumors and blood marrow cells has been studied in experiments on CBA, BALB/C and C57B1/6 mice with the Ehrlich adenocarcinoma and Lewis lung carcinosarcoma treated with adaptogenic drugs of Rhodiola Rosea extract, a synthetic analog of Rhodiola phenol derivative, methyluracil and their combinations with cyclophosphamide. The extract and derivative are shown to protect the myelopoietic tissue from the toxic action of cyclophosphamide, retaining or increasing the suppressive effect of the latter towards clonogenic tumors cells. These data can be the reason for using the extract and derivative during the antitumor chemotherapy as biological response modifiers.

Animals↗
PubMed1990

[Effects of Rodiola extract on the cytotoxic activity of natural killer cells of the liver, spleen, lungs and small intestine in rats after partial hepatectomy].

In experiments on Wistar rats the cytotoxic activity of NK on the 1, 2, 10 days after partial hepatectomy (PH) and the application of Rodiola extract (RE) was studied. After 5 injections of RE the NK activity in gut increased by 112%, and after 12 ones (towards the end of experiment) by 222% in the spleen. The decreasing of this index in a first day after PH in lung, liver and gut was shown to restore in these tissues to the end of experiment. The absence of NK cytotoxicity diminishing just after PH in all the tissues was shown in operated animals, receiving RE and the decreasing of this index was found only in the lungs (by 335%).

Animals↗
PubMed1989

[Decrease in the growth rate of Ehrlich's tumor and Pliss' lymphosarcoma with partial hepatectomy].

In experiments with transplantable tumors, partial hepatectomy, Rhodiola rosea extracts or their combination were shown to inhibit the rate of Ehrlich's tumor and Pliss' lymphosarcoma as well as dissemination of the latter. These effects are to a certain extent attributed to production of humoral factors by the liver inhibiting clonogenic activity of tumor cells in vivo and in vitro.

Animals↗
PubMed1989

[The role of thrombocyte aggregation function in the mechanism of the antimetastatic action of an extract of Baikal skullcap].

The advancement of Pliss' lymphosarcoma in rats was shown to be associated with disorders of platelet-mediated hemostasis presenting with either lowered or increased aggregation activity of platelets. In the latter case, a direct correlation was observed between functional activity of thrombocytes, on the one hand, and degree of tumor advancement and its metastatic activity, on the other. Extract of Scutellaria baicalensis Georgi was shown to produce a normalizing effect on platelet-mediated hemostasis whatever the pattern of alteration which points to the adaptogenic activity of the drug. This activity is thought to be responsible for the drug's antitumor and, particularly, metastasis-preventing effect.

Animals↗
PubMed1987

[Dilution of the toxic action of 5-fluorouracil on the mucosa of the small intestine in mice using the sap of plantain].

The study was concerned with an attempt at reducing the acute toxic effect of 5-fluorouracil (5-FU) on gut mucosa in mice with Ehrlich ascites tumors. An official preparation of plantain sap was shown to ward off this effect and to contribute to the normalising of certain parameters of epithelial cells. The DNA level of tumor cells showed a more drastic decline after combined treatment with 5-FU and the preparation than after the cytostatic drug alone.

Animals↗
PubMed1987

[Enhancement of the selectivity of the action of the cytostatics cyclophosphane and 5-fluorouracil by using an extract of the Baikal skullcap in an experiment].

In experiments with murine and rat transplantable tumors, Scutellaria baicalensis Georgii extract treatment was shown to ameliorate cyclophosphamide and 5-fluorouracil-induced myelotoxicity and to decrease tumor cell viability. This was partly attributed to a pronounced antistressor action of the extract and its normalizing effect on some homeostatic parameters.

Animals↗
PubMedDate not supplied

[Mechanism of differential effect of low dose adaptogens on the functional activity of normal and transformed cellular elements in vitro].

Influence of water solutions of chemically pure adaptogen--synthetic analog of Rhodiola Rosea extract phenol composition (SAR) on functional activity of hemopoietic and tumor cells of mice with Ehrlich ascite cancer was studied in vitro. The periodical character of SAR effects was shown to be different for both types of cells, and at 1 x 10(-2) and 1 x 10(-26) M concentrations simultaneous stimulation of blood marrow cells colony-forming activity and inhibition of the latter in tumor elements was revealed. Essential changes of reactions of both cell types after adding the DNA-dependent RNA polymerase blocker Actinomycin D permit to suggest SAR effects to be connected with drug influence on the membrane RNA of the target cells.

Animals↗
PubMedDate not supplied

[The effect of low concentrations of adaptogen solutions on the functional activity of murine bone marrow cells in vitro].

Influence of water solutions of chemically pure adaptogens--a synthetic analog of Rhodiola rosea extract phenol combination (SAR) and Dibazol on the functional activity of mice hemopoietic cells in vitro was studied. A clear periodical character of drugs effects manifestation with a tendency to the stimulating activity domination was revealed. A reliable stimulation of clonogenic activity was in correlation with 4 x 10(-11) and 4 x 10(-15) adaptogens molecules in SAR and Dibazol solutions per 1 blood marrow cell. This phenomenon is suggested to be connected with the solvent (water) molecules changes and the formation of structures, keeping the information of adaptogenes with possible translation of the latter during the process of consistent dissolution of the solvent.

Animals↗