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S Nabeshima

Publications and source records attributed to S Nabeshima.

83 records · Page 5Linked to original sources
PubMed1980

[Electron-microscopic study of the arachnoid cyst (author's transl)].

The primary arachnoid cyst developed on the left middle cranial fossa of 5 year-old girl was examined with electron-microscope and discussed its pathogenesis. The cyst wall was mainly composed of two distinct layers, one was compact arranged flattened cells and others loosely arranged of collagen fibers and fibroblast. Various junctions were observed between those cells. Those features were similar to that was seen in normal arachnoid membrane. However, the abundant attenuated cell processes, whole formation and psammoma body were observed in cyst wall. Those finding suggested the cyst was congenital arachnoid malformation, resulting from abnormal proliferation of developing arachnoid cells.

Arachnoid↗
PubMed1979

[A case of Maffucci's syndrome with intracranial chondroma (author's transl)].

A rare case of Maffucci's syndrome with intracranial chondroma was reported and the literature reviewed. A 16-year-old female high-school student was reffered to our service with 2 month history of diplopia and headache. She had been noticed to have multiple subcutaneous blueish nodules in the lower extremities and multiple body deformities in the four extremities since 6 months old. A biopsy of a skin lesion revealed cavernous hemangioma with calcified thrombi. Another biopsy from the deformed right femur showed it to be enchondroma. Skull series, carotid and vertebral arteriographies, and CT scan revealed a left parasellar mass, which had brought her sensory impairment of the left V1 and the left abducens palsy. The biopsy of the extradural mass in the medial portion of the left middle fossa proved it to be chondroma identical with the right femur lesion. So far as one year postoperative follow-up, she has been doing well with the postoperative sequela of mild left oculomotor paresis, having no evidence of malignant degeneration.

Adolescent↗
PubMed1978

[Diagnosis of abnormal spine motion with cineradiography (author's transl)].

For the past one year, 13 patients were studied 20 times with cineradiography to diagnose abnormal spine motion, which was quite informative compared to usual plain spine X-ray pictures. The direct radiation dosis was only 2.35 rem/min on taking cineradiography at the speed of 60 frames/sec. The camera used was Cardoskop-U and the X-ray generator was Pandoros Optimatic, both of which were of Siemens make. It was keenly recognized that cineradiography was useful to diagnose 1) solidity of spine fusion, 2) effect of spinal traction, 3) efficacy of immobilizing apparatus for spine and 4) abnormal spine motion on dynamic way.

Adolescent↗
PubMed1975

Junctions in the meninges and marginal glia.

The meninges of various mammals were prepared for examination with the electronmicroscope by thin sectioning or freeze-fracturing. Particular attention was given to the distribution of tight junctions in order to determine the basis for the meningeal barrier between the blood circulating in dural vessels and the cerebrospinal fluid in the subarachnoid space. While some dural blood vessels are fenestrated, those in the subarachnoid space are not and their component endothelial cells are joined by an extensive system of tight junctions. An extensive and continuous system of tight junctions was also found in a layer of specialized cells at the border of the arachnoid with the dura. This arachnoid barrier layer is apparently the only basis of the meningeal barrier because often cellular layers in the dura and arachnoid lack tight junctions although they are linked by gap junctions and desmosomes. In particular, tight junctions are lacking at the border of the "subdural space" which is actually a fascial plane within the dura. Tight junctions are also lacking between astrocytes at the surface of the brain but these cells are linked by gap junctions and a new type of intercellular junction. The distribution of these junctions, as well as assemblies of intramembranous particles at the astrocytic border, raises the question whether this layer might have a role in the exchange of certain substances between the brain and cerebrospinal fluid.

Animals↗
PubMedDate not supplied

The effectiveness of anti-retroviral drug therapy for HIV-1 is associated with HIV-1 proviral DNA levels and viral selection.

The effect of combination anti-retroviral therapy regimens on HIV-1 proviral DNA levels in peripheral blood mononuclear cells was examined in 12 HIV-1-positive patients, using endpoint dilution polymerase chain reaction and serial cloning, and sequencing of the gag region of HIV-1. The major clone was defined as the most numerous of 10 analysed clones, and observation periods ranged from 8 months to 32 months (mean 19.7 +/- 10.2 months). In five patients (one with primary-stage HIV-1 infection) receiving three anti-retroviral drugs, HIV-1 RNA reduced to undetectable levels (i.e. < or = 100 copies/ml). HIV-1 proviral DNA and the number of major clones reduced in four of these patients. HIV-1 RNA levels reduced, but remained detectable, in five other patients. In the two remaining patients (both receiving two rather than three anti-retroviral drugs), HIV-1 RNA levels increased. These results suggest that the population of major clones may be affected when HIV-1 RNA levels reduce following combination regimens of anti-retroviral therapy.

Adult↗