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Biomedical subjects

S Nakamoto

Publications and source records attributed to S Nakamoto.

At least 127 records · Page 7Linked to original sources
PubMed1979

Leukocyte counts and arterial blood gases in nonrenal psoriatic patients treated with extracorporeal devices: Preliminary report.

Four psoriatic patients with normal renal function were treated with RP-6 dialyzers. There was a significant decrease in the leukocyte counts at 5 mins of hemofiltration and it remained the same without rebound leukocytosis at 60 mins. Leukopenia was not accompanied by changes in PaO2 or PaCO2 and thus not accompanied by hypoxemia. C3 values were also unchanged, although a tendency to decrease was noted. Leukopenia and hypoxemia may not be related.

Blood Gas Analysis↗
PubMed1979

Bis(2-ethylhexyl) phthalate levels in nonuremic patients treated with extracorporeal devices.

DEHP levels after treatment were studied in 6 nonuremic psoriatic patients undergoing extracorporeal therapy. Serum DEHP levels at the end of therapy of these patients were significantly lower than that of maintenance hemodialysis patients. DEHP and/or its metabolites were excreted by the normal kidneys, although the excretion of nonmetabolized DEHP by the kidneys was minimal. There was no correlation between serum DEHP levels of these nonuremic patients and the type of artificial kidney used or the mode of therapy employed.

Blood↗
PubMed1978

Bis(2-ethylhexyl)phthalate concentrations in the serum of hemodialysis patients.

Bis(2-ethylhexyl) phthalate is extracted from artificial kidneys, both in vivo and in vitro. Perfusion of whole blood through arterial-,venous tubing (that supplied with the dialyzer) for 1 h in vitro yielded 3.23 mg of the compound, while similar perfusion of the tubing plus the artificial kidney yielded 6.10 mg. Its mean concentration after dialysis in patients undergoing hemodialysis was 751 microgram/liter of serum. Patients who had undergone more than 50 hemodialysis treatments showed significantly higher postdialysis concentrations than patients who had undergone fewer. Uptake of bis(2-ethylhexyl) phthalate by the blood during a dialysis session followed two patterns. One set of patients showed a maximum concentration at 3 h, the second set showed a steady increase until the end of dialysis. Bis(2-ethylhexyl) phthalate appeared to be rapidly cleared from blood, most being removed within 5 to 7 h of completion of dialysis.

Chromatography, Gas↗
PubMed1977

Determination of plasticizer levels in serum of hemodialysis patients.

Serum DEHP levels were measured on 27 hemodialysis patients at various time intervals. The following results were obtained: 1) Predialysis levels of DEHP occurred in only one of 22 samples. 2) Postdialysis serum levels reached a mean of 751 nGm DEHP/ml serum. 3) Samples from patients with less than 50 hemodialysis treatments gave a mean of 558 nGm/ml, while those with more than 50 treatments gave a mean of 973 nGM/ml. These numbers were found to be significantly different at a 95% confidence level. 4) No difference in DEHP levels were found for males and females. 5) The appearance of DEHP during dialysis and its disappearance after dialysis were found to be biphasic. 6) No correlation was found between serum DEHP and triglyceride levels in postdialysis serum samples.

Female↗
PubMed1976

In vitro and in vivo evaluation of ceftezole, a new cephalosporin derivative.

Ceftezole, a new cephalosporin derivative, was compared with cefazolin, cephaloridine, and cephalothin. Data obtained indicate that it is a broad-spectrum antibiotic, with almost identical antimicrobial activity against pathogenic organisms isolated from patients. The therapeutic effect of ceftezole on experimental infections in mice was similar to that of cefazolin and was superior to that of cephalothin. The binding of ceftezole to serum proteins was somewhat less than that of cefazolin. The concentrations of ceftezole in the sera of test animals and human volunteers were determined after intramuscular injection of 20 mg/kg and after a single dose of 500 mg, respectively. The concentration of ceftezole in the serum of volunteers peaked at 24.9 mug/ml 15 min after injection and remained effective (about 2.6 mug/ml) at 4 h. The half-life in serum under the same conditions was 56 min, i.e., about one-half that of cefazolin. The 24-h urinary recovery rate was 87.5%. Most of the administered ceftezole was excreted unchanged mainly through the urinary tract. The biliary excretion rate in SD strain rats after intramuscular injection of 20 mg/kg was about 4.4%. As compared with commercially available cephalosporins, ceftezole was second only to cefazolin in biliary excretion rate. Various tissue levels of ceftezole in animals were higher than cephalothin but, with the exception of renal levels in the early stage after administration, were lower than cefazolin.

Adult↗