The motor activity of mice treated by scotophobin (1, 2, 4, 6 micrograms) was tested in a photoresistor actometer 24, 48 and 72 h after injection. Scotophobin in doses of 4 and 6 micrograms per mouse increased significantly the motor activity as compared with controls injected with saline only. This result suggests that shortening of dark box time, found by some authors after injection of scotophobin, seem to be the consequence of the enhanced motor activity of mice. Thus the effect of scotophobin on the behavior of animals is not specific and this substance can not be considered responsible for the "memory transfer".

Animals↗

PubMed1978

The effect of first visual stimulation on incorporation of labelled leucine into cerebral cortex of binocularly deprived kittens.

One-month old kittens, binocularly deprived with hoods from birth, were used. Before the experiments in which visual stimulation was applied the brainstem of kittens was transected at the pretrigeminal level. Cortical EEG activity and ocular behavior indicated that the isolated cerebrum of preparations was usually awake during experiment. Patterned visual stimulation was directed to one hemisphere, while the other was used as a control. Visual stimulation evoked in some cases (in 8 out of 17) an increase of incorporation of labeled leucine into the proteins of the striate cortex. Electrophoresis on polyacrylamide gel did not reveal any differences in the pattern of insoluble proteins between the stimulated and control visual cortex. It is suggested that first visual stimulation may enhance the protein metabolism of striate cortex in young kittens. Some unknown up to now physiological factors (motivation, attention?) may be critical for these phenomena.

Animals↗

PubMed1977

The effect of the assay temperature on brain acetylcholinesterase activity of two antarctic fish species.

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Acetylcholinesterase↗

PubMed1976

Activity of some enzymes in the cortex of the cat with pretrigeminal brainstem transection.

The visual and somatic sensory cortex were investigated. The activity of acetylcholinesterase and lactate dehydrogenase was similar in the pretrigeminal and non-operated cats. The activity of these two enzymes, as well as that of choline acetyltransferase, butyrylcholinesterase and acid phosphatase was similar 3 and 8 h after the pretrigeminal transection. Results support the possibility of utilizing the pretrigeminal cat for investigations of biochemical correlates of learning.

Acetylcholinesterase↗

PubMed1976

Electrophoretic patterns of insoluble proteins in the sensory cerebral cortex of visually deprived and normal kittens.

Insoluble proteins were investigated in the visual cortex (area 17) and somatic sensory cortex of one month old kittens. Visual deprivation did not affect the electrophoretic pattern but changed percentage distribution of proteins in both cortices. Some of the alterations seemed to appear only in the visual cortex, which is morphologically and functionally deficient in deprived kittens. Electrophoretic patterns of normal kittens differed from those of normal adult cats.

Age Factors↗

PubMed1976