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S Nikolaeva

Publications and source records attributed to S Nikolaeva.

5 recordsLinked to original sources
PubMed2006

An evaluation of variables affecting the stability and performance of down-flow anaerobic fixed bed reactors treating piggery wastewater.

The influence of the most important variables on the stability and performance of down-flow anaerobic fixed bed reactors treating piggery wastewater after primary sedimentation was evaluated at HRT in the range of 1-6 d and influent substrate concentration in the range of 2 to 12 g TCOD l(-1). The effect of HRT was more pronounced compared to that of influent strength. An increase in the HRT increased the process stability and process performance at different influent strengths. TCOD, SCOD, BOD5 TSS, organic nitrogen (N) and Orthophosphate (P) removals increased with the HRT, independently of the initial substrate concentration (S0). The increase in S0 brought about an increase in the attached biomass concentration (X) at the end of the experiment. Two empirical models based on the individual effect of HRT, X and S0 were evaluated and found to be adequate to describe the influence of these variables on the process performance. The first model took all the above-mentioned variables into consideration while the second model was simplified and based on the use of HRT as the only independent variable. The results obtained by using both models were found to be similar. This demonstrated that independently of the characteristics of the operation, the behaviour and performance of the reactors were comparable. The methane yield coefficient was found to be 0.3371 methane g(-1) TCOD removed.

Anaerobiosis↗
PubMed1999

A rare case of fibrosarcoma of the inferior vena cava expanding into the right atrium.

The authors report in detail a case of fibrosarcoma of the inferior vena cava. A 53-year-old female presented with echographic and computed tomographic evidence of a solid formation in the porta hepatis that fused with the inferior vena cava. Because of appearance and rapid development of symptoms of right cardiac failure, the patient was transferred to the Clinic of Cardiac Surgery and underwent an emergency operation. A solid formation arising from the inferior vena cava and expanding into the right atrium was found during the operation. The operation performed was not a radical one. Fibrosarcoma of the inferior vena cava was proved on histological examination. A single therapeutic course with vincristine and farmorubicin was administered. The patient died from recurrence of the malignancy 26 months after the operation. The epidemiologic, diagnostic, and therapeutic aspects of the case are discussed in relation with the literature data.

Echocardiography↗
PubMedDate not supplied

Cellular and humoral systemic and mucosal immune responses stimulated by an oral polybacterial immunomodulator in patients with chronic urinary tract infections.

An oral polybacterial immunomodulator Urostim (U), composed of killed cells and their lysates from E. coli expressing type 1 and Pili, E. coli Rc mutant, P. mirabilis, K. pneumoniae and E. faecalis was created for immunoprophylaxis and immunotherapy of urinary tract infections (UTIs). In experimental animal models, the stimulating effect of U on lymphocyte functional activity, macrophage phagocytosis and antibody producing cells, was established. In this study the immuno-modulating effects of U on the proliferating capacity and ultrastructural morphologic changes of lymphocytes, cytokine production and specific systemic humoral and mucosal immune responses in patients with UTIs have been evaluated. Patients enrolled in the study, received orally 50 mg U daily for a period of three months. On days 0, 30 and 90 a quantitative analysis was performed on lymphoproliferative responses to polyclonal mitogens, IL-2 and the specific antigen U, the production of specific serum and saliva IgA, IgM and IgG antibodies to all components of U and the concentration of pro-inflammatory cytokines. There was significant improvement of non-specific and specific lymphoproliferative responses on days 30 and 90 after the onset of treatment with U, confirmed by electronmicroscopic studies. The highest concentrations of serum proinflammatory cytokines TNF-alpha, IL-1beta and IL-6 were registered at baseline followed by a decrease until the end of the observation period. This finding correlates with the gradual decrease of immune activation as measured by the spontaneous lymphocyte proliferation. Data from the production of specific antibacterial antibodies in serum and saliva show two types of reactions. The first type was registered in patients with low pre-treatment levels in whom the concentration of specific antibodies increased on days 30 and 90. The second type of reaction was observed in patients with high pre-treatment levels, which dropped on day 30 and were usually followed by an increase at the end of the study. These results provide evidence for the immuno-modulating effect of U. Our data show that the oral administration of the polybacterial immunomodulator Urostim stimulates adequate cellular and humoral systemic and mucosal immune responses in patients with chronic UTIs.

Adjuvants, Immunologic↗