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Biomedical subjects

S O Osipova

Publications and source records attributed to S O Osipova.

13 recordsLinked to original sources
PubMedDate not supplied

[Ecdysten in the treatment of giardiasis].

The drug ecdisten as tablets is the natural compound ecdisteron was extracted from Rhaponticum carthamoides (Willd.) Jljin. Ecdisten was tested in the treatment of 32 and 3 patients with persistent and acute giardiasis, respectively. A ten-day course of ecdisten, 5 mg 3 or 4 times a day, resulted in a clinical and parasitological recovery in 22 (68.7%) and 3 patients, respectively. After the reuse of a ecdisten course in 4 patients with persistent giardiasis wherein its initial dose was increased, recovery was achieved in 3 cases, the efficacy of the agent was 78.1%. Ecdisten should be used to treat giardiasis, in its chronic pattern or resistance to conventional giardicial agents.

Administration, Oral↗
PubMedDate not supplied

[Intestinal parasitic diseases in HIV-infected patients in Uzbekistan].

Intestinal parasitic diseases were diagnosed in 100 HIV-infected patients at different stages of disease (its asymptomatic form, persistent generalized lymphoadenopathy, pre-AIDS, and AIDS) (Group 1), 100 Tashkent residents (Group 2), and 349 patients with gastrointestinal diseases, allergic dermatoses, and skin depigmentation foci (Group 3). The HIV-infected patients were found to have virtually all parasites, such as Giardia lamblia, Cryptosporidium parvum, Chilomastix mesnili, Entamoeba coli, Iodamoeba butschlii, Entamoeba histolytica/dispar, Endolimax nana, Blastocystis hominis, Enlerobius vermicularis, Ascaris lumbricoides, Hymenolepis nana, detectable in the population of Tashkent. The highest infestation with intestinal protozoa, including nonpathogenic amoebas and helmninths, was found in Groups 1 and 3. However, in all the forms of HIV infection, the infestation with E. histolytical/dispar was 10 times greater than that in Groups 2 and 3 (1% and 0.8%, respectively). G. lamblia was detected in 16, 21, and 45.2% in Groups 1, 2, and 3, respectively. In all the HIV-infected patients, the content of CD8 lymphocytes was increased, but that of CD20 lymphocytes was normal. Parasites were detectable with different levels of CD4 lymphocytes, but C. parvum was found only if its count was > 200/ml. In the HIV-infected patients, the hyperproduction of IgE was caused mainly by helminths rather than protozoa. In these patients, the increased level of IgE was also noted in the absence of parasites.

AIDS-Related Opportunistic Infections↗
PubMedDate not supplied

[Early and late E-rosette-forming neutrophils in persistent lambliasis].

The E-rosette-forming capacity of neutrophils and T-lymphocyte counts in the peripheral blood of 21 patients suffering from persistent giardiasis (PG) were found. A control group included 29 healthy persons. The patients with PG showed a significant increase in the count of early and late E-rosette-forming neutrophils along with a substantial decrease in the count of T-lymphocytes, which is indicative of an inflammatory process located mainly in the gallbladder. It is concluded that according to the neutrophil counts, immunodeficiency may not be regarded as a factor predisposing to PG.

Adult↗
PubMedDate not supplied

[The characteristics of HLA antigen distribution among patients with persistent lambliasis].

Fifty patients suffering from persistent giardiasis and 257 healthy persons from Uzbekistan were examined. HLA-typing was carried out by the Terasaki microlymphocytotoxicity technique. The patients with persistent giardiasis were characterized as a significant prevalence of HLA-B5, HLA-B14, HLA-DR3, DR4, DR7 and haplotypes HLA-A9-B5 and A1-B5. These haplotypes and HLA antigens can be considered as markers of predisposition to persistent giardiasis.

Adolescent↗