Myasthenia gravis associated with cyclosporin treatment.
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Cyclosporine↗
Biomedical subjects
S O'Reilly
Publications and source records attributed to S O'Reilly.
Brain death--an opposing viewpoint.
Recent and proposed legislation to establish "brain-related" criteria of death has uniformly confounded irreversible cessation of total brain function with the death of the human person. Much of the confusion comes from widespread misunderstanding of how the word "death" is used and what it means. Cessation of total brain function, whether irreversible or not, is not necessarily linked to total destruction of the brain or to the death of the person. Further, to take vital organs or to otherwise treat people as though they were dead already on the basis of these recent criteria is morally unacceptable to most Orthodox Jews and Christians.
Brain↗
Pigment binding of copper in human bile.
The copper profile of human bile was studied using a Cu-free preparative polyacrylamide gel system. 85 percent and 91 percent of the Cu in the bile of two subjects was found in a leading pigmented band with no additional detectable copper in the remainder of the gel in either subject. The content of the pigmented band was recovered from the gel by an intermediate electrophoretic technique. Subsequent n-butanol extraction removed contaminating bile salts with the formation of a Cu containing pigmented precipitate. Using thin-layer cellulose chromatography this precipitate was separated into two pigments which on the basis of color and diazotization reaction were believed to be conjugated bilirubins. Addition of Cu transformed the pigments into biochemically different species. 64Cu verified copper binding by the altered pigments.
Bile↗
Kinky hair disease. Study of copper metabolism with use of 67Cu.
Metabolism of labeled Cu (67Cu) was studied in three patients with kinky hair disease (KHD). Labeled Cu was administered first intravenously and, later, orally. We determined oral absorption, excretion, and internal kinetics of this metal. Patients with KHD absorbed 11% to 13% of Cu given orally, compared to 46% by unaffected controls. Total excretion of Cu given intravenously during the first seven days after administration was greatly reduced in patients with KHD. The biological half-life of 67Cu in patients with KHD was increased by a factor of 2 to 3 over the normal control. Most of the labeled Cu was retained by the patient's liver, while in the control subject there was more rapid movement to the Cu to circulation (ceruloplasmin). Red blood cells of patients with KHD incorporated orally administered Cu preferentially, which was sufficient to prevent anemia.
Age Factors↗