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S Ochoa

Publications and source records attributed to S Ochoa.

135 records · Page 8Linked to original sources
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Gender differences in a sample of schizophrenic outpatients.

Our objective was to study gender differences in schizophrenia, comparing clinical, social, and illness course characteristics. A sample of 239 schizophrenic (DSM-IV criteria) outpatients were administered the following instruments: service use and demographic questionnaires, the Positive and Negative Symptom Scale (PANSS), the Disability Assessment Scale (DAS), and the Global Assessment of Functioning (GAF) scale. The female to male ratio was 1/2. Men had an earlier age at onset. Women were more likely to be married and to live independently, and there were more unemployed men. Social functioning was slightly better in women (lower DAS scoring). No differences were found in symptomatological variables (global or separate PANSS scales), nor in type of schizophrenia. Course of illness in the past year appeared to be similar, except for longer hospital stays in men. We conclude that schizophrenic women had a significantly better social functioning, despite the lack of remarkable symptomatic differences between genders.

Adolescent↗
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Pediatric phase II cancer chemotherapy trials: a Pediatric Oncology Group study.

PURPOSE: This study reviewed the Pediatric Oncology Group experience with phase II clinical trials in children (< 21 years of age) with refractory tumors. PATIENTS AND METHODS: Patients registered in Pediatric Oncology Group phase II studies were evaluated. Patients had to be < 21 years of age with recurrent and refractory measurable disease. Tumor types and response rates were determined. Death on therapy from either drug toxicity, progressive disease, infection, or hemorrhage was measured. Tumor-specific, disease-free survival curves were calculated by Kaplan-Meier analysis. RESULTS: Between 1984 and 1994, 2,465 patient entries were made on 45 phase II trials. Malignancies registered included acute lymphocytic leukemia (ALL) (16.7%), acute myeloid leukemia (AML) (12.0%), osteogenic sarcoma (7.8%), neuroblastoma (7.2%), astrocytoma (7.2%), medulloblastoma (7.1%), glioma (6.7%), ependymoma (6.1%), and others (29.2%). The overall response rate was 19.6% (CR + PR) for children entered on phase II trials. Tumor-specific response rates ranged from 62.1% (23/37) for children with Hodgkin's disease to no responses (0/23) in patients with hepatoblastoma. When comparing single versus multiagent trials, a significantly better initial response rate was seen in the latter studies. However, 5-year survival was comparable. Progression-free survival for all tumor histologies were 12.9% and 9.2% at 2 and 5 years, respectively. Death on study was seen in 11.6% of the patients; however, only three deaths were directly related to drug toxicity. There were no significant gender differences in regards to response, progressive disease, or death on study. CONCLUSION: Phase II studies conducted in children offer a considerable likelihood of therapeutic benefit without exposing these patients to untoward toxicity.

Antineoplastic Agents↗
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[Gender differences in schizophrenia. A literature review].

Gender differences in schizophrenia have been the subject of extensive research in the last two decades. The study of these differences can help us improve the understanding of schizophrenia as well as find new treatment options. Recent studies have challenged the classical view that incidence and prevalence rates of schizophrenia are similar in men and in women. As regards disorder onset, most studies agree that it is earlier in men. Also, most studies suggest that women have a better premorbid functioning and, especially in short-term follow-up studies, a more benign course. Data on clinical characteristics are often conflicting, but most studies point to a greater severity of negative symptoms in men. Research on treatment response, both pharmacological and psychosocial, indicates as well differences between men and women. Results of neuropsychological studies are very conflicting. By contrast, brain imaging studies suggest gender differences in morphologic and in functional images. As regards family studies, most of them agree that schizophrenic women are more likely than men to have family history of the illness.

Adolescent↗
PubMedDate not supplied

[Symptomatology and gender in schizophrenia].

OBJECTIVE: To study the possible symptomatological gender differences in a sample of schizophrenic outpatients. METHOD: A sample of 239 schizophrenic patients (DSM-IV criteria) was administered a demographic questionnaire and the Positive and Negative Syndrome Scale (PANSS). The PANSS symptoms were grouped in accordance with Kay's five factors model. RESULTS: The ratio women/men was 1/2. Women had a later age at onset. Women were more likely to be married and to live independently, as well to be occupationally active. Both groups were similar in subtype of schizophrenia. No differences were found in PANSS' results; in global or grouped scores. CONCLUSION: No symptomatological differences were found between women and men with schizophrenia.

Adult↗
PubMedDate not supplied

[Insight and use of health resources in patients with schizophrenia].

INTRODUCTION: The objective of this work is to study the insight level of patients with schizophrenia and how the insight is related to sociodemographic, clinical and compliance variables. Besides, we evaluated the influence of insight level in the utilization services. PATIENTS AND METHODS: Sixty nine patients meeting schizophrenia criteria were selected. They were evaluated with a sociodemographic questionnaire, clinical and social adjustament scales (SCAN, GAF, PANSS, DAS), a services and cost questionnaire (CECE) and the insight scale of Amador (SUMD). RESULTS: The results were that gender, degree of education, type of residence and some clinical and disability variables were related to insight level. On the other hand, patients with a lower insight level attented more to emergencies and less to mental health centers. CONCLUSION: Insight level is an important determinant of adequate health service use in schizophrenia.

Adult↗
PubMedDate not supplied

[Comparative study of the needs of patients with schizophrenia by gender].

OBJECTIVES: To evaluate the gender differences in the needs of the people with schizophrenia who live in the community. METHOD: We randomly selected 231 patients with schizophrenia who were receiving treatment in one of the five mental health care centres that participated in the study. Patients were evaluated with a socio-demographic questionnaire, the Positive and Negative Syndromes Scale (PANSS) and Camberwell Assessment of Need (CAN) questionnaire. The CAN evaluate 22 needs, that we could be grouped into five subscales: service needs, basic needs, functioning need, health needs and social needs. All needs were evaluated by the professional and the user independently. RESULTS: Professionals detected more needs in men than in women, but users did not report such difference. Both professionals and users detected more service needs for women (p< 0.005) and more basic needs for men (p< 0,01-0.005). Only professionals detected more functioning needs in men (p< 0.05). CONCLUSIONS: Professionals detect more needs than users and detect more needs for men than for women. Women have less needs in food, personal care, home care, and daily activities. These gender differences should be taken into account when designing treatment programs for schizophrenia.

Adolescent↗