Biomedical subjects
Publications and source records attributed to S Ochudło.
The case report presents a 61-year-old female patient with profound dementia and coexisting hematological disorders suggesting Addison-Biermer's disease. Two possible diagnoses were considered; dementia of Alzheimer type or dementia secondary to pernicious anaemia. This case report reflects diagnostic difficulties concerning dementia syndrome in the presence of other causative factors.
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The purpose of this study was to evaluate the effect of various therapeutic regimens on: 1) intrathecal IgG synthesis on the basis of IgG Index value, 2) oligoclonal IgG spectrum visualized by SDS-PAGE of unconcentrated CSF, 3) CSF antibody specific activity against MBP estimated by solid phase RIA and expressed in cpm/micrograms IgG, and 4) immune complex (CIC) level in the CSF estimated by C1q binding solid phase RIA. CSF antibody against Gal-C and ganglioside was also estimated. Patients with clinically definite MS were selected according to 4 therapeutic regimens: group 1, subjected to Mega-dose prednisone therapy (4000 mg over 54 days), group 2, subjected to moderate dose prednisone therapy, group 3 subjected to Mega-dose Solu-Medrol therapy (7500 mg over 10 days), and group 4, subjected to intravenous Cyclophosphamide therapy (4000 mg over 10 days). This last group was characterized by chronic progressive course of disease. Intrathecal IgG production was significantly reduced in all 4 groups as a result of therapy. More pronounced reduction was obtained in Mega-dose prednisone (p below 0.001) and CY (p below 0.001) treated group. Therapeutic regimens did not influence the IgG oligoclonal pattern. The moderate dose prednisone therapy and Mega-dose Solu-Medrol therapy on CSF IgG anti-MBP antibody specific activity were less effective than the Mega-dose prednisone medication. CY therapy did not influence anti-MBP antibody specific activity in MS group characterized by chronic progressive course of disease. The influence of therapeutic regimens on elevated CIC level in the CSF was insignificant. In our study CSF the anti-galactocerebroside antibody appeared to be of IgM class.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
The authors report a case of coexistence of Eales disease and multiple sclerosis in which signs of perivenous retinitis preceded by 25 years the appearance of neurological changes. Considering the similarity in the course of both disease and the histological character of perivascular changes the authors suggest presence of a common causative factor and pathological mechanism of the development of clinical changes.
A giant intracranial aneurysm is described in a woman aged 70. CT image suggested an expanding lesion.
The effects of treatment with cyclophosphamide (CY) and prednisone on the spectrum of oligoclonal IgG (olgG) of the cerebrospinal fluid were studied in 33 cases of slowly progressing multiple sclerosis. CY was administered intravenously in a total dose of 4 g during 10 days. This treatment was supplemented with prednisone 775 mg p.o. given during the following 25 days. The electrophoretic separation of proteins in non-concentrated CSF and in serum before and immediately after the treatment was done by Laemili's method with associated impregnation with silver salts. The analysis of these electrophorograms showed the presence of qualitative and quantitative changes of olgG spectrum. Quantitative changes found in 59% of the cases included more pronounced (8% of cases) appearance or attenuation (51% of cases) of individual bands. Qualitative changes in form of elimination of bands were noted in 29% of cases, and in 12% of cases new bands appeared. The authors conclude that, the results confirm a strong immunosupressive effect of CY on olgG in slowly progressing m.s.