PubMed Health⌕ Search

Biomedical subjects

S Odashima

Publications and source records attributed to S Odashima.

At least 91 records · Page 5Linked to original sources
PubMed1980

Transplacental and neonatal carcinogenesis by 1-butyl-1-nitrosourethan in the ACI/N rat.

1-Butyl-1-nitrosourethan (BNUR) and 1-butylurethane (BUR), a precursor of BNUR, were administered prenatally or neonatally to ACI/N rats. A few neurogenic tumors were induced in the offspring of mother rats that had received BNUR at the late stage of pregnancy and in the animals that had received one subcutaneous injection of BNUR within 24 hr after birth. No neurogenic tumors were observed in rats treated with BUR prenatally or neonatally.

Animals↗
PubMed1979

Carcinogenic effect of N-ethyl- and N-amyl-N-nitrosourethans on female Donryu rats.

Carcinogenic effect of N-ethyl-N-nitrosourethan (ENUR) and N-amyl-N-nitrosourethan (ANUR) was examined by continuous oral administration or topical application to female Donruy rats. Oral administration of 100 ppm solution of ENUR induced 100% of tumors in the forestomach, 46%, 80%, 71%, and 51% in the oral cavity and pharynx, esophagus, duodenum, and liver, respectively. On the other hand, the incidence of forestomach tumors was 78%, that of oral cavity and pharynx, and esophagus was 93% and 98%, respectively, in rats given 400 ppm suspension of ANUR. In addition, topical application of ENUR induced tumors of the skin as well as tumors of the forestomach and liver.

Administration, Oral↗
PubMed1979

Antitumor effect of pyridine N-oxides having 1-(2-chloroethyl)-1-nitrosoureidoalkyl and 1-methyl-1-nitrosoureidoalkyl groups.

Pyridine N-oxides having 1-(2-chloroethyl)-1-nitrosoureidoalkyl or 1-methyl-1-nitrosoureidoalkyl groups were evaluated for their antitumor activity against AH13 hepatoma and L1210 leukemia. Among them, 1-(2-chloroethyl)-1-nitroso-3-(2-pyridylmethyl)urea N-oxide (1), its tosylate (2), 1-(2-chloroethyl)-1-nitroso-3-(2-pyridylethyl)urea N-oxide (4), and 1-(2-chloroethyl)-1-nitroso-3-(3-pyridylmethyl)urea N-oxide (6) were highly active against both tumors in ip-ip system. These compounds were also active in ip-iv and ip-po systems of L1210. On the other hand, pyridine N-oxides having 1-methyl-1-nitrosoureidoalkyl group were all inactive against AH13 and weakly active against L1210. Effect on blood cells in Donryu rats bearing EDEN-5 erythroblastic leukemia cells was tested with these 1-(2-chloroethyl)-1-nitrosoureidoalkylureas. These compounds caused leucopenia and compound (4) was only slightly effective against EDEN-5.

Animals↗
PubMed1979

Hepatic changes in male ACI/N rats on low dietary levels of sterigmatocystin.

Three groups, each consisting of 36 male ACI/N rats, were fed a diet containing 10, 1, or 0.1 ppm sterigmatocystin for life span. There was no dose--effect relationship on tumor incidence or mean survival time. Toxic and preneoplastic changes of the parenchyma such as hyperplastic foci were observed in the liver of experimental groups with dose--effect relation, but hepatocellular carcinoma was observed only in one rat of 10 ppm group. In addition to these lesions, hemangiosarcomas of the liver were also observed in the highest and middle-dose groups, 3/26 and 1/29, respectively. There was not significant difference in the incidence of other tumors in experimental or control groups.

Animals↗
PubMed1978

Sensitivity difference of rat ascites hepatoma AH-13 and mouse leukemia L-1210 to nitrosourea derivatives.

The structure-activity relationship in different sensitivity of AH-13 and L-1210 to nitrosourea nad related derivatives was examined. N-Methyl-N-nitrosoureido derivatives, such as 1-methyl-1-nitrosourea (MNU) and 1, 1'-polymethylene-bis(3-substituted 3-nitrosourea), were inactive against AH-13 and slightly active against L-1210. On the contrary, 1, 1'-polymethylene-bis(3-substituted 1-nitrourea) derivatives were more active against AH-13 than against L-1210. The nitrosoureas which had bis(2-chloroethyl) group at the terminal were highly active against AH-13 and L-1210. One of denitrosated derivatives, 1, 1'-ethylene-bis[3-(2-chloroethyl)urea], was active against AH-13 alone. In addition, diisocyanates, nitrourea, ammonium carbamate, and 1-methyl-1-nitrourea, which are related to the nitrosourea compounds, were also tested for their activity against AH-13 and L-1210. Diisocyanates and nitrourea were active against AH-13 alone, while other compounds were all inactive.

Animals↗