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S Oguchi

Publications and source records attributed to S Oguchi.

57 records · Page 4Linked to original sources
PubMed1987

[X-ray photodensitometric study of the second metacarpal--a new method of evaluation of metabolic bone diseases].

For the purpose of mass screening of metabolic bone diseases, the usefulness of X-ray photodensitometry should be reappraised. The optical density pattern of the second metacarpals was measured with a video camera, and was processed by a computer to be calibrated and adapted to an elliptical bone model. The computer calculated the optimal bone mineral distribution in the bone model to reproduce the original density pattern. The bone was evaluated in terms of the bone mineral mass, the cortical bone mineral density and the second moment of inertia. With these parameters, this system provides a method of quantitative as well as qualitative evaluation of metabolic bone diseases. Osteoporosis revealed the highest physical efficiency in bone mineral distribution. Inefficient distribution shown in renal osteodystrophy was attributed to the malfunction in the control system of bone remodeling metabolism.

Absorptiometry, Photon↗
PubMedDate not supplied

Growth factors in breast milk and their effect on gastrointestinal development.

Breast milk contains various biologically active factors including, hormones, peptide growth factors, and cytokines. Epidermal growth factor (EGF) and insulinlike growth factor-I (IGF-I) are two of the major milk-derived peptide growth factors. Colostrum contains higher levels of these growth factors than mature milk does, and, these factors are relatively resistant to proteolysis and stable in the G-I tract. There are specific receptors found in G-I mucosa. Luminal EGF and IGF-I stimulate growth and development of gastrointestinal tract. Intestinal epithelial Caco-2 cells are a good model for studying physiological roles of exogenous growth factors in the G-I development. Effect of EGF and IGF-I on proliferation, differentiation, and IGF-binding protein (IGFBP) production of intestinal Caco-2 cells were studied. Both EGF and IGF-I increased cell proliferation in dose dependent manner. The number of IGF-I receptors on Caco-2 cells increased after differentiation, in contrast to EGF binding which was reported to decrease. Caco-2 cells produced at least three IGFBPs, namely IGFBP-2, -3, and -4. The profile of these IGFBPs varied with differentiation. Secretion of IGFBP-2 and -3 increased with differentiation, but IGFBP-4 diminished. IGF-I stimulated mainly IGFBP-3 production, while EGF stimulated predominantly IGFBP-4. The effects of IGF-I and EGF on IGFBP secretion diminished with increasing cell differentiation. Thus, the interaction between intestinal epithelial cells and extrinsic growth factors are complex and the stage of differentiation is an important determinant of this phenomenon.

Animals↗