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S Ohgi

Publications and source records attributed to S Ohgi.

47 records · Page 3Linked to original sources
PubMed1989

Inherited deficiency of functional and free form protein S.

We studied hemostatic function in a family with a history of venous thromboembolic disease. In the propositus, a 36-year-old male, the results of assays for the coagulation, anticoagulation and fibrinolytic factors were almost normal. However, the functional protein S activity in his plasma was less than 5% of normal. Similar laboratory findings were noted in his paternal uncle and two sisters who had recurrent thrombotic episodes and in his asymptomatic father as well. The mean total protein S antigen level in these five patients was 37% (range 19-66%) by conventional Laurell rocket immunoelectrophoresis. However, by crossed immunoelectrophoresis of their plasmas and Laurell rocket immunoelectrophoresis of the polyethyleneglycol 6000-treated plasmas, the free form of protein S was undetectable in their plasmas. The levels of C4b-binding protein in the plasma of three of the five patients were in normal range, and that those in the remaining two were below the normal level. These findings suggest that the recurrent thrombotic disease in this family is due to inherited deficiency of protein S, particularly of the functionally active free form of protein S.

Adult↗
PubMed1987

[Crural arterio-venous fistula due to orthopedic surgery. A report of a case].

A rare case of crural arterio-venous fistulae due to orthopedic surgery was presented. A 60-year-old female patient received a corrective fibulotomy just below the fibular head under the diagnosis of osteoarthropathy of the left knee joint 3 years ago. Intractable pain and swelling of the left leg appeared shortly after operation, probably due to deep vein thrombosis. A faint thrill on the left saphenous vein afforded a clue for detecting a co-existing arterio-venous fistula. Confirmative cine-angiography revealed a few a-v-fistulae at the level of crural trifurcation, which might have exacerbated the symptoms of deep vein thrombosis. On entering the trifurcation, which was embedded in scar tissues, there were two a-v-fistulae, originating separately from the peroneal artery and the posterior tibial artery. These fistulae were closed directly, one from the peroneal artery through the lateral approach resecting the upper one third of the fibula, and the other from the posterior tibial artery through the standard medial approach. Postoperative course was uneventful, and the swollen leg subsided rapidly with remarkable improvement of symptoms such as pain, dullness, night cramp of the calf and etc. Concerning to the medical literature on iatrogenic arterio-venous fistula due to orthopedic surgery, no similar case has been reported at least in these ten years on crural arterio-venous fistula after corrective fibulotomy.

Arteriovenous Fistula↗
PubMed1986

Relative accuracy of the diagnostic components of noninvasive carotid arterial tests: a comparison of pulsed Doppler arteriography and spectrum analysis.

Pulsed Doppler ultrasonography (UA), sound spectrum analysis, and subjective interpretation of the audible signal are valuable methods for assessing carotid arterial disease; however, the relative contribution of each in making a diagnosis is disputed. To investigate this issue, 258 noninvasive carotid studies with measured x-ray comparisons were reviewed. Internal carotid spectra, UA images, and images combined with the technician's comments were each interpreted blindly by three independent readers. Percentage of stenosis was categorized into six groups: 0, 1% to 24%, 25% to 49%, 50% to 74%, 75% to 99%, and 100%. Each reader's assessment of the individual noninvasive components and his overall reading of the complete study were compared with x-ray findings and with those of the other two readers. The readings of the three observers were consistent within each diagnostic component (p less than 0.001). For each reader, the technician's comments significantly improved the accuracy of ultrasonic imaging alone (p less than 0.001). Spectrum analysis was as good as the image plus technician's comments and, for two of three readers, was better than the image alone (p less than 0.001).

Angiography↗
PubMed1986

Physiology of the peaked finger pulse in normal and cold-sensitive subjects.

A unique peaked digital pulse contour (DPC) is frequently observed in patients with cold sensitivity, but the pathophysiology of this pulse remains obscure. To investigate the responses of the DPC to cold exposure, finger blood pressure (FBP), finger blood flow (FBF), and finger skin temperature (FST) were measured in fingers of both hands of 13 normal subjects and in 16 patients with cold sensitivity. The ratio, FBP/FBF, was used to estimate small vessel resistance (SVR). One hand was immersed sequentially in water at 40 degrees, 30 degrees, 20 degrees, and 10 degrees C, while the other hand remained in room air. DPCs were classified as normal (N), intermediate (I), intermediate-peaked (IP), peaked (P), obstructive (O), and spastic obstructive (SO). At room temperature, fingers with I, IP, O, and SO pulses had increased SVRs and decreased FSTs, and those with O and SO had decreased FBP. On cold exposure IP pulses appeared in both hands of both normal and cold-sensitive subjects, but P pulses developed only on the cooled side. IP and P pulses were associated with an increase in SVR. We concluded that IP pulses are related to reflex sympathetic arteriolar vasoconstriction, that P pulses imply vasoconstriction produced directly by cold exposure, and that O, SO, or absent pulses are indicative of digital arterial vasospasm.

Adolescent↗
PubMed1986

Continuous measurement of transcutaneous oxygen tension on stress test in claudicants and normals.

Subjective evaluation of hemodynamics by stress tests in claudicants should be made to establish severity of functional ischemia. As an indispensable examination of vascular laboratory, non-invasive, simple methods can only satisfy methodological conditions. The aim of this study was to apply the transcutaneous oxygen tension measurement for a non-invasive, continuous detector of hemodynamic responses in skin circulation by stress tests and to elucidate the clinical usefulness of this technique. Investigated were 20 legs in patients with intermittent claudication and 9 legs in healthy persons as controls. Ten legs with ischemic pain during exercise loading revealed abnormal transcutaneous oxygen tension (tcPO2) curves in comparison with those with in normal legs. Over the continuous tcPO2 curve, the minimum tcPO2 at the reverse postural change after exercise loading was the most reliable indicator for evaluating induced ischemia. We conclude that hemodynamic responses on stress tests should be analyzed both during and after exercise loading, and that the continuous tcPO2 curve constitutes a useful method for evaluating and following up the claudicants.

Adolescent↗
PubMed1981

Quantitative evaluation of the skin circulation in ischemic legs by transcutaneous measurement of oxygen tension.

We tried to apply transcutaneous oxygen tension (tcPo2) in evaluating the ischemic leg quantitatively from the standpoint of the skin circulation. The tcPo2 measurement was performed on the pretibial and dorsal skin at rest, on exercise loading, and during oxygen inhalation; tcPo2 on the chest wall was measured as a standard value. The subjects consisted of 47 patients with ischemic legs and 20 normal healthy males without ischemic legs. tcPo2 in the pretibial skin had a tendency to decrease with aging. There was a correlation between pretibial tcPo2 and ankle pressure (r = 0.51, p less than 0.02). In the affected leg, each mean pretibial tcPo2 under 3 different conditions was much lower than that of control. Pretibial tcPo2 of patients also correlated well with the Fontaine classification of clinical severity of ischemic legs. We concluded that transcutaneous measurements of oxygen tension at the pretibial region are useful in evaluating the ischemic leg quantitatively.

Adult↗
PubMedDate not supplied

Heterotaxy syndrome with pancreatic malrotation: CT features.

We report the case of an asymptomatic elderly man with heterotaxy syndrome who presented with incomplete pancreatic rotation and an aplastic pancreatic uncinate process, polysplenia, nonrotation of the intestine, a midline liver, a midline gallbladder, a right-sided stomach, and interruption of the inferior vena cava with azygos continuation. To our knowledge, pancreatic malrotation with resultant oblique placement has not been described in patients with heterotaxy syndrome, and we speculate that the pancreatic rotation was interfered with by the left lobe of the midline liver in the embryo.

Abnormalities, Multiple↗
PubMedDate not supplied

Chemosensitivity testing of irinotecan (CPT-11) in ovarian and endometrial carcinomas: a comparison with cisplatin.

BACKGROUND: The tetrazolium dye (MTT) assay is useful in predicting chemosensitivity. MATERIALS AND METHODS: Using an MTT assay, we designed an in vitro chemosensitivity test for irinotecan (CPT-11) and compared it with sensitivity to cisplatin in gynecologic carcinomas removed from 49 patients. RESULTS: The mean tumor inhibition rate (I.R.: %) for irinotecan was relatively inferior to the I.R. for cisplatin in both ovarian and endometrial carcinomas [40.2 vs 53.2 and 43.5 vs 58.0] (p < 0.05, respectively). In ovarian carcinomas, 13 (48.1%) of 27 cases were irinotecan-sensitive (I.R. > or = 50%) and 77% of the tumors were judged to be irinotecan and/or cisplatin-sensitive. There was no significant difference in the I.R. for irinotecan among the various histologic subtypes. Comparing in vitro sensitivity to irinotecan with clinical responses in 8 patients who received irinotecan, the overall accuracy of the MTT assay for evaluating clinical effectiveness was 75% (6 out of 8). In endometrial carcinomas, we found 9 (40.9%) out of 22 cases to be irinotecan-sensitive. The I.R. for irinotecan in G1 carcinomas [33.5] was significantly lower than in G2 carcinomas [59.3] (p < 0.05). CONCLUSION: Our data suggest that irinotecan appears to have moderate antitumor activity in vitro against both ovarian and endometrial carcinomas and that differences in irinotecan sensitivity among the histologic subtypes were evident in the latter but not in the former.

Adult↗
PubMedDate not supplied

Mucoepidermoid carcinoma of the trachea with airway hyperresponsiveness.

We report a case of mucoepidermoid carcinoma of the trachea in a 23-year-old pregnant female in her 39th week. The patient had cough and wheezing in the early morning for 9 months before admission. No abnormalities were detected on a chest roentgenogram. At Caesarean section, fiberscopy revealed a polypoid lesion narrowing the trachea. The pathologic diagnosis made from the biopsy specimen obtained was low-grade mucoepidermoid carcinoma and the lesion was resected. Airway hyperresponsiveness was shown before resection with airflow limitation, however, airway reactivity and airflow limitation improved 1 year after resection.

Adult↗
PubMedDate not supplied

Determination of amputation level in ischemic legs by means of transcutaneous oxygen pressure measurement.

A new technique for the determination of the most appropriate amputation level in ischemic legs is described and the results obtained in 31 amputations are reported. This method takes the line joining the points with transcutaneous partial oxygen pressure (tcPO2) of 30 mmHg as the lower margin of the incision. A success rate of 90.3%, with primary healing, was obtained in the 31 amputations performed.

Amputation, Surgical↗