Determination of HLA-A, -B and -C types in 43 Japanese patients with multiple sclerosis (MS) and of DR type in 25 MS patients was carried out using antisera from the 7th International Histocompatibility Workshop. The results were compared with 46 controls typed simultaneously. Twenty-three patients were also tested for HLA-Dw2. The conclusions were: 1) There were no significantly higher occurrences of HLA-A3, B7, Dw2 or DRw2 in Japanese MS. 2) Japanese MS might nevertheless be associated with the human major histocompatibility complex, because HLA-B40 was significantly less frequent in MS and two anti HLA-DRw sera, 7w008 and 034, reacted positively more often against lymphocytes from MS patients.

Epitopes↗

PubMed1977

Noninvasive measurement of the intracardiac blood flow by means of ultrasound techniques.

A new noninvasive method of measurement of the intracardiac blood flow by means of ultrasound techniques is described. In this system the "M-sequence modulated Doppler method" and the method of ultrasonotomography are used in combination. An arbitrary space within the heart can be selected by ultrasonocardiotomography and the blood flow profiles can be observed by the "M-sequence modulated Doppler method." The new Doppler flow meter system described in this paper can be applied not only for the diagnosis of heart diseases, but also for the study of pathophysiology of the blood flow and of the factors responsible for the dilatation of the heart. Further studies are required from the viewpoints of medicine and engineering to accumulate sufficient data before routine application of the method described in this paper is fully warranted.

Coronary Circulation↗