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S Oida

Publications and source records attributed to S Oida.

82 records · Page 5Linked to original sources
PubMed1977

[Clinical experience with S-6436 in urinary tract infections (author's transl)].

S-6436 is a new preparation of sustained release cephalexin. Twenty-eight patients with urinary tract infections were orally given 500mg of S-6436 twice a day for about 7 days, and the following results were obtained: 1) Excellent clinical responses were observed in 8 cases, good in 18 cases and failure in 2 cases. Effectiveness was 93%. 2) As for the side effect, gastrointestinal symptoms were observed in one case out of 28 cases, but they disappeared after the completion of the treatment. No other side effects due to S-6436 were observed. S-6436 has as much effectiveness and safety as compared with usual cephalexin preparations. The frequency of the administration of S-6436 is twice a day, which means that S-6436 is more convenient in giving it to patients than usual cephalexin preparations.

Acute Disease↗
PubMedDate not supplied

Expression of bone morphogenetic protein genes in the human dental pulp cells.

Dental pulp has a potential to induce ectopic bone formation, but little is known about its mechanism. We thought that bone morphogenetic proteins (BMPs), members of the transforming growth factor-beta (TGF-beta) superfamily, are involved in the osteoinductive activity of dental pulp. In order to prove this assumption, we constructed a cDNA library from primary culture cells of human dental pulp (HDP cells), and screened the library with previously cloned cDNAs for mouse BMP-2 and -6 as probes. Three distinct cDNA clones encoding human BMP-2, -4 and -6 were isolated. By Northern blot analysis, specific transcripts of the genes of those BMPs were detected in the HDP cells. It was concluded that the BMPs were expressed in a certain population of dental pulp cells and might play some roles in ectopic bone formation by dental pulp.

Adolescent↗
PubMedDate not supplied

A case of Japanese cleidocranial dysplasia with a CBFA1 frameshift mutation.

Cleidocranial dysplasia (CCD), which is caused by mutations of the core binding factor alpha 1 (CBFA1)/runt-related gene 2 (Runx2), is an autosomal, dominantly inherited disorder of high penetrance affecting skeletal ossification and tooth development. Recently, we found a novel frameshift mutation 383-T-insertion (S128F) in exon 3 in the CBFA1 gene of a Japanese classic CCD patient. We describe our detailed investigation of the patient with CCD associated with the CBFA1 mutation. The patient showed the characteristic expression of CCD, such as dysplasia of the clavicles, patent fontanelles, short stature, impacted supernumerary teeth, and delayed eruption of the permanent teeth. In addition to these characteristics, orthopantomography delayed ossification of the mandibular symphysis and a three-dimensional computed tomograph (3D-CT) analysis showed hypoplasia of the zygomatic arch. Furthermore, the acellular cementum of an impacted supernumerary tooth was absent in this patient. Thus, the CBFA1 mutation was critical for the pathogenesis of CCD in this patient.

Amino Acid Sequence↗