Biomedical subjects

S Onisawa

Publications and source records attributed to S Onisawa.

5 recordsLinked to original sources

PubMed1990

Breathing patterns in asthmatic children during attack.

Breathing patterns in asthmatic children during attack were studied using multielectrode impedance pneumography. A great number of respiration patterns were analyzed by a personal computer. During severe attacks, a pattern of prolonged expiratory time was noted. Inspiratory time, however, did not change, regardless of the severity of the asthmatic attack. No remarkable changes in breathing patterns were recognized during mild attacks. It was, therefore, considered that breathing patterns remained essentially unchanged except in cases of severe asthmatic attacks.

Adolescent↗

PubMed1989

Concurrent poststreptococcal acute glomerulonephritis and Schönlein-Henoch purpura.

A 5-year-old Japanese boy developed concurrent poststreptococcal acute glomerulonephritis (PSAGN) and Schönlein-Henoch purpura (SHP). An elevated titer of ASK on admission confirmed the preceding streptococcal infection. Arthritis of the left knee and petechiae on admission were regarded as features of SHP. The presence of SHP was further confirmed by the pathological finding of leukocytoclastic vasculitis in the skin. PSAGN was strongly suspected due to the findings of microscopic hematuria and hypocomplementemia in the acute phase. The concurrence of SHP and PSAGN suggests similar underlying pathophysiological processes as poststreptococcal sequelae. At the height of the illness, peripheral blood lymphocyte subset analysis showed a marked increase in the suppressor inducer T subset and a reciprocal decrease in the helper T subset. This alteration in T lymphocyte subsets was regarded as indicative of the immunological derangement in this patient.

Child, Preschool↗

PubMed1989

Five cases of autoimmune neutropenia in infancy or early childhood.

Five cases of chronic neutropenia which developed mainly in infancy were investigated and followed up for 5 to 34 months. Antineutrophil antibody levels were assayed by the direct and indirect immunofluorescence methods using flow cytometry. Selective neutropenia, myeloid hyperplasia and/or maturation arrest of myeloid series cells in the bone marrow, and the demonstration of antineutrophil antibody in the sera and on autologous neutrophils, indicated that the neutropenias involved were autoimmune in nature. Two cases exhibited spontaneous recovery 12 and 14 months respectively after the diagnosis, with concomitant marked decreases in antineutrophil antibody levels. Our study of these five cases supports the view that this disorder may be a clinical entity with a relatively consistent clinical presentation and course. Within this framework of the disorder, however, a clear heterogeneity in clinical presentation and course was also noted in our cases. Clinical severity in this disorder may be enhanced by arrested maturation of myeloid series cell in the bone marrow.

Agranulocytosis↗

PubMed1989

Induction of HLA-DQ antigen expression on a human promyelocytic leukemia cell line HL-60.

A variant strain of HL-60, which is positive for HLA-DR antigen, was induced to express HLA-DQ antigen following treatment with phorbol esther. It was preceded by cell cycle arrest in the G1 phase and was accompanied by augmented phagocytosis. This differential expression of HLA class II antigens on this subline may contribute to understanding the functional role of HLA class II antigens in the hematopoietic differentiation of macrophage cells.

Cell Cycle↗

PubMed1987

HLA and C4 in subacute sclerosing panencephalitis.

The frequencies of HLA-A, B, C, DR and DQ antigens were studied in 63 Japanese patients with subacute sclerosing panencephalitis (SSPE). The results could not confirm the statistical association between SSPE and HLA antigens. In addition, the allele frequencies of complement components C4, C2 and BF were determined in the 20 haplotypes with 10 unrelated SSPE patients. A significant association of C4A QO with SSPE in Caucasians was not found in Japanese.

Complement C2↗