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S Orlandi

Publications and source records attributed to S Orlandi.

17 recordsLinked to original sources
PubMed1989

Defective natural killer cell activity in puerperal hyperprolactinemia.

Prolactin (PRL) influences immune reactivity in animals and in humans and both T-cell abnormalities and reduced natural killer (NK) cell activity have been reported in women with pathological hyperprolactinemia. To investigate further the possible interactions between PRL and the immune system in humans, we analysed T-cell phenotypes and NK cell activity in 15 women with physiological hyperprolactinemia of the puerperium and in 45 age-matched healthy normal cycling women. Puerperal women displayed a normal T-cell phenotype but a significant reduction in the number of Leu-7+ and Leu-11+ cells, associated with a decreased NK cell activity, as measured against K-562 target cells. There was a significant inverse correlation between the raised serum PRL levels and both the number of Leu-7+ cells and NK cell activity. These data confirm an important immunoregulatory role for PRL in humans and suggest a direct inhibitory effect of the chronically raised PRL concentrations on the maturation of NK cells.

Female↗
PubMed1988

Changes in serum and lipoprotein lipids, and apolipoprotein B and A-I, in patients with different types of primary hyperlipoproteinaemia treated with gemfibrozil.

Gemfibrozil was given at the dose of 600 mg twice daily to 16 type IIa, 13 type IIb and 11 type IV hyperlipoproteinaemic patients for four months. At the end of the fourth month of therapy low-density lipoprotein (LDL) cholesterol decreased on the average by 18% in type IIa, by 11% in type IIb and increased by 37% in type IV patients. Very-low-density lipoprotein (VLDL) cholesterol and triglycerides fell by 57% in type IIb and by 58% and 76% respectively in type IV subjects. High-density lipoprotein (HDL) cholesterol rose in all groups of patients owing to the increase of the HDL2 subfraction. However, in type IIa the change did not reach the level of statistical significance. Apoprotein B decreased in type IIa and in type IIb patients and apoprotein A-I significantly increased in type IIb and IV patients. The individual changes in total VLDL and LDL lipids and in apoprotein B could be related to their pretreatment level. The cholesterol triglyceride ratio significantly increased in LDL and HDL fractions and the effect was greater in the subgroup of patients with the greatest abnormality in lipoprotein lipid composition. On the whole the differential effects of gemfibrozil on serum lipoprotein concentration and composition in the various types of hyperlipoproteinaemia can be regarded as a trend toward a normalization and may be explained by the multiple effects of the drug on lipid metabolism.

Adolescent↗
PubMed1987

Phenotypic and functional abnormalities of T lymphocytes in pathological hyperprolactinemia.

The phenotype and function of T cells circulating in patients with pathological hyperprolactinemia were analyzed and compared to those in sex- and age-matched control subjects. Two-color immunofluorescence study revealed an increased number of CD4+ TQ1+ cells and the presence of phenotypically immature CD1+ T cells, also exhibiting transferrin surface receptor, in peripheral blood of the hyperprolactinemic patients. After chronic treatment with the dopamine agonist bromocriptine, T-cell abnormalities disappeared. In addition, some untreated patients showed enhanced T-cell suppressor activity in an in vitro pokeweed mitogen-driven B-cell transformation assay. These immunological findings confirm a link between neuroendocrine and immune systems in humans.

Antigens, Differentiation, T-Lymphocyte↗
PubMed1986

Reduced number of natural killer cells in patients with pathological hyperprolactinemia.

Human natural killer (NK) cell activity, as measured against K-562 target cells, was evaluated in 23 untreated and in 11 bromocriptine-treated hyperprolactinemic female patients and in 63 age-matched healthy women using 51Cr-release assay. The NK cell activity was significantly reduced in untreated hyperprolactinemic patients with respect to that of normal subjects, but therapy with bromocriptine restored NK cell function of patients to the levels of normal controls. Moreover, a reduced number of Leu-7+ cells and of large granular lymphocytes in hyperprolactinemic patients, as compared to normal controls and bromocriptine-treated subjects, correlated well with the decreased NK activity. Finally, 'in vitro' incubation with purified human prolactin, did not affect NK cell activity of blood mononuclear cells. The present results demonstrate that pathological hyperprolactinemia, in which a tuberoinfundibular dopaminergic defect has been postulated, is also associated with a reduction in NK cell number and function and indicate a possible interaction between prolactin, neuroendocrine system and NK cell lineage in man.

Antigens, Differentiation, T-Lymphocyte↗
PubMed1979

[Clinico-statistical review of 74 cases of subcutaneous rupture of the Achilles tendon].

The Authors report 74 cases of subcutaneous hole of Achille's tendon that were treated surgically. 52 patients were clinically controlled at a distance from 1 to 5 years. The functional result at a distance is good in 67,3% of cases, satisfactory in 25%, insufficient in 4%. They point out an hig incidence of local post-operating complications (29,8%), especially when the paratendinea medial incision has been made. The authors suggest to opt for a paratendinea lateral incision and, experimentally, to drop the use of hemostatic string.

Achilles Tendon↗
PubMedDate not supplied

[Hohmann's operation in the treatment of humeral epitrochleitis].

7 cases of epicondylitis surgically treated by a Hohmann operation and perforations were checked. These were the only cases of epicondylitis to be operated at the G. Pini Orthopaedic Institute, Milan, over a decade. Careful evaluation of the results showed complete success in all cases. The association of the Hohmann operation and perforations is therefore to be recommended in the rare forms of epicondylitis which do not respond to nonsurgical treatment.

Adult↗
PubMedDate not supplied

[Surgical treatment of calcaneal spurs].

74 operations for the removal of calcaneal spurs at the "G. Pini" Orthopaedic Clinic in Milan over the post 20 years have been examined. After a brief summary of the main aetiopathogenetic theories, the symptomatological picture and various surgical techniques, and the data on the cases encountered are analysed. A high percentage of failures is reported. It is hoped that all cases of talalgia due to calcaneal spur will initially be given conservative therapy. Only if this fails should surgery be considered.

Adolescent↗
PubMedDate not supplied

[The treatment of loose diaphyseal fractures of the humeral diaphysis using the hanging cast method].

A personal series of loose diaphyseal fractures of the humeral diaphysis, treated with the hanging plaster case method, has been examined in order to assess results. These were positive in most treated cases, with a complication percentage comparable to that obtainable with other methods. Although it is not considered that the usual treatment of reduction and plaster cast thoraco-brachial immobilisation should be abandoned, it is considered that the hanging cast is an equally valid alternative in all cases in which the patient's general condition represents a contraindication to the application of a bulky chest-extended cast.

Adult↗