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Biomedical subjects

S Oruç

Publications and source records attributed to S Oruç.

10 recordsLinked to original sources
PubMed2003

Relationship of sexuality with psychological and hormonal features in the menopausal period.

Women may experience some mental and sexual problems between the ages of 40 years and 60 years due to serious changes in the hormonal system. The aim of this study was to examine the relationships between the changes in sex hormones, sexual behaviours, depression and anxiety levels of women who were in either the premenopausal, perimenopausal or postmenopausal period. The subjects of this cross-sectional study consisted of 324 women who attended the Gynaecology and Obstetrics Out-Patient Ward of Celal Bayar University Hospital. Of this group, 37.0% (n = 124) were postmenopausal, 27.2% (n = 84) perimenopausal and 35.8% (n = 116) premenopausal. Beck Depression Inventory (BDI), State and Trait Anxiety Inventories (STAI-I and II) and a questionnaire on sexual behaviour which was prepared for this study by the authors, were applied to all of the attendees and serum sex hormone levels were analyzed. Beck Depression Anxiety, STAI-I and STAI-II scores and sexual behaviours did not show any statistically significant difference among these three groups. The frequency of sexual intercourse was lower in women with high BDI scores. The rate of painful intercourse was higher in women with high STAI-I scores. The frequency of sexual intercourse, sexual desire and orgasm decreased and painful intercourse increased in women with high STAI-II scores. The frequency of sexual intercourse decreased significantly as the age or follicle stimulating hormone level of women increased. These findings have revealed that the menopausal state did not affect the sexual behaviour, and psychological state of women between the ages of 40 and 60 years, but the increase in anxiety and depression scores affected the sexual life in a negative manner.

Adult↗
PubMed2001

Assessment of the effectiveness of postmenopausal tibolone therapy on neural functions by measuring visual evoked potentials: a placebo-controlled study.

OBJECTIVE: To assess the effect of hormone replacement therapy on neural transmission in postmenopausal women using tibolone by a non-invasive, objective way. STUDY DESIGN: In a randomised, 3 cycle, placebo-controlled study, neurovisual transmission in optic pathways were evaluated by measuring visual evoked potentials (VEP). After neuroophtalmologic examination, eligible subjects were randomised into two groups. Treatment group (n=38) were given tibolone 2.5mg daily continuously for 3 months and control group (n=20) were treated with placebo. A baseline VEP measurement before the treatment and then at the end of first, second and third month were obtained by the EMG-evoked system in the Department of Neurology, University of Celal Bayar, Manisa, Turkey. RESULTS: Data from 31 women from treatment group and 16 from control group were available for evaluation. The mean P(100) latency values, which indicate the transition time period between the optic stimuli and electrical change recorded on the occipital area by the skin electrodes, have showed a significant decrease for the study group (from 100.39+/-0.58 to 97.90+/-0.65 ms, P<0.01) at the end of the first month of treatment according to the baseline values. This difference between two groups has remained constant during the study period. CONCLUSION: The change in latency measurements of VEP, reflecting the functional status in optic pathways from retina to occipital cortex were significantly different in the treatment group than in that of control. We concluded that a facilitating effect of tibolone was observed on neurovisual transmission.

Anabolic Agents↗
PubMed2000

Fit of titanium and a base metal alloy metal-ceramic crown.

STATEMENT OF PROBLEM: Titanium has been widely used in dental implantology. However, problems remain for use of titanium in prosthodontics. PURPOSE: This study evaluated the marginal and inner fit of metal-ceramic restorations and frameworks made with a nickel-chromium alloy (Remanium CS) and a commercially pure titanium (Rematitan). Fit was compared with SEM before and after firing of ceramic materials. MATERIAL AND METHODS: Sixteen metal frameworks were cast with each casting material, 8 frameworks were used directly to evaluate measurements for fit (RCS: Remanium CS frameworks and TI: Rematitan frameworks). Porcelain was applied on the other 8 frameworks (RCSP: Remanium CS-porcelain and TIP: Rematitan-porcelain), fired, and then the fit was measured. Measurements were recorded at 3 points for marginal fit evaluation and at 3 points for inner fit. RESULTS: Significant differences were recorded among the occlusal (JK) values of groups tested (P <.05). Marginal fit and inner fit of Remanium CS frameworks were better than Rematitan frameworks. However, there were no substantial differences detected among groups after firing the ceramic superstructures. CONCLUSION: The fit of the base metal alloy metal-ceramic crowns was better than the commercially pure titanium metal-ceramic crowns. However, both artificial crowns were clinically acceptable.

Analysis of Variance↗
PubMed2000

Changes in the plasma activities of protein C and protein S during pregnancy.

The objective of the study was to determine the changes in the plasma activities of protein C and protein S that occur during normal pregnancy In this prospective cross-sectional study, plasma activities of protein C and protein S were measured in 32 normal pregnant women in the first, second and third trimester and 6 weeks after delivery There was a significant fall in protein C and protein S activities during normal pregnancy compared with the post-puerperal period. The activities of protein C and protein S also gradually decreased throughout pregnancy (p < 0.01). Increasing plasma volume during normal pregnancy and its dilutional effect might play some role in the low activities of protein S observed. The normal falls in protein S and protein C activities make it difficult to diagnose protein S and C deficiency during pregnancy. Based on our findings, if a woman has a thromboembolic event during pregnancy, testing for a definitive diagnosis of protein C or protein S deficiency or functional failure should be delayed until at least 6 weeks postpartum.

Cross-Sectional Studies↗
PubMed1999

A comparative study on the effects of apraclonidine and timolol on the ophthalmic blood flow velocity waveforms.

PURPOSE: To evaluate the effects of topical timolol and apraclonidine on retrobulbar blood flow velocity waveforms in a group of healthy volunteers. METHODS: Apraclonidine 1% and timolol maleate 0.5% single dose administrations were crossed over double masked in 12 healthy volunteers. The intraocular pressure measurements were followed by Doppler examination of the ophthalmic artery and the central retinal artery. RESULTS: Intraocular pressure was reduced significantly on both treated and fellow eyes after timolol (p = 0.003, p = 0.04 respectively) and after apraclonidine (p = 0.002, p = 0.01 respectively). After apraclonidine administration end diastolic velocity, mean velocity decreased and pulsatility index increased in the ophthalmic artery of both treated and fellow eyes. Resistivity index increased and peak systolic velocity decreased only in the ophthalmic artery of treated eyes. All Doppler indices remained nonsignificant for central retinal artery of both eyes. After timolol administration there were no significant changes of the Doppler indices in the ophthalmic artery and central retinal artery of the treated and fellow eyes. CONCLUSION: Topical timolol and apraclonidine significantly reduced the intraocular pressure. Single dose administration of apraclonidine 1% increased the vascular impedance distal to the ophthalmic artery. On the other hand, timolol 0.5% had no effect on vascular impedance.

Adrenergic alpha-Agonists↗
PubMed1999

Investigation of microleakage between titanium and porcelain.

Porcelain was applied to 30 titanium and 30 Remanium CS disc-shaped frameworks in order to investigate the microleakage. Each group was divided to three subgroups each containing 10 specimens and representing the different firing cycles (10 specimens for opaque + dentine; 10 specimens for opaque + dentine + enamel; and 10 specimens for opaque + dentine + enamel porcelain + glaze application). All the specimens were stored in 37 degrees C distilled water for 2 weeks and subjected to 100 thermocycles between 5 and 55 degrees C with 30 s dwell time. The specimens were then stored in 5% basic fuchsin dye for 2 days. The washed, rinsed and air dried specimens were embedded in autopolymerizing resin and sectioned diametrically. The stereoptical investigations were performed by three independent investigators. The data were analysed by the Mann-Whitney U-test. The statistical analysis revealed that the different number of firings does not affect the amount of microleakage. However, it should be emphasized that the use of titanium would be beneficial regarding the relatively lower values obtained from the titanium-porcelain group.

Dental Leakage↗
PubMed1999

Sexual behaviour during pregnancy.

The effects of pregnancy on sexuality were studied in 158 pregnant women. They were surveyed by questionnaire about sociodemographic variables and sexual behaviour. Dyspareunia was common in our study group during pregnancy. Pregnancy had a negative effect on orgasmic quality. Dyspareunia and orgasmic quality influenced coital frequency. Coital frequency declined as the month of the pregnancy increased. Pregnancy is a potent influence on sexuality irrespective of an individual's conditioning.

Adolescent↗
PubMedDate not supplied

The pharmacokinetics and effects of diltiazem in rabbits.

PURPOSE: To investigate the effect of diltiazem on wound healing after the creation of conjunctival flaps in rabbit eyes. Also, to investigate the pharmacokinetics of diltiazem in rabbits after subconjunctival and topical administration. METHODS: For the histopathological study, a limbal-based flap was prepared and diltiazem was injected subconjunctivally for five days after the surgery. The rabbits were euthanised 20 days after surgery. The effectiveness of diltiazem on wound healing was evaluated by histopathological examination and measurement of the thickness of subconjunctival fibrous tissue. For the pharmacokinetic study, diltiazem was applied topically or injected subconjunctivally. Aqueous paracenteses were performed 0.5, 1, 2, 4 hours thereafter. RESULTS: The histopathological study found no difference in thickness of the subconjunctival fibrous tissue in control and diltiazem-treated eyes. No significant toxicity was observed in eyes treated with diltiazem. The peak aqueous concentration was 3.8 +/- 0.4 microg/ml after topical application and 15.3 +/- 1.1 microg/ml after subconjunctival injection. The peak aqueous concentration was achieved 1/2 hours after administration in both cases. CONCLUSIONS: Diltiazem did not appear to affect wound healing at the dose tested. Topical and subconjunctival diltiazem successfully penetrated the aqueous humor of rabbit eyes.

Animals↗
PubMedDate not supplied

Bilateral orbital hemorrhage induced by labor.

We describe a woman in whom bilateral orbital hemorrhage occurred during labor. She developed sudden proptosis and complete loss of vision bilaterally. After a stillbirth, she underwent total hysterectomy because of atonic uterus and postpartum hemorrhage. The location of the hematomas was confirmed by magnetic resonance imaging. Clinical resolution occurred in one month but both eyes remained blind. Fundoscopy revealed bilateral atrophy of the optic discs.

Adult↗