[Clinical pathophysiological studies on coronary circulation. 3. The effects of so-called coronary vasodilator agents on coronary circulation in various diseases].
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Adolescent↗
Biomedical subjects
S Osugi
Publications and source records attributed to S Osugi.
Estimation of the shelf life of a drug in its solid state. I. An application of Lacey's theory to a kinetic analysis of an air oxidation of ascorbic acid in its solid state.
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Ascorbic Acid↗
Stability of ascorbic acid in fused system containing ascorbic acid in mannitol.
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Ascorbic Acid↗
Decreased modulation by endothelium of noradrenaline-induced contractions in aorta from stroke-prone spontaneously hypertensive rats.
Influences of endothelium on contractions of aortic ring preparations from 15 to 17 weeks old stroke-prone spontaneously hypertensive rats (SHRSP) and age-matched Wistar-Kyoto rats (WKY) were compared. Noradrenaline-induced contraction was potentiated by endothelium removal; the potentiation was greater in the WKY aorta. Noradrenaline (10(-5) M) induced a biphasic contraction in endothelium-intact WKY aorta, while endothelium-intact SHRSP aorta or endothelium-removed preparations of both strains showed a monophasic sustained contraction. The tension changes in high-K-induced contracture of the endothelium-intact preparation was less pronounced in both WKY and SHRSP aortae. The relaxation by acetylcholine (10(-5) M) of endothelium-intact aortae, precontracted with noradrenaline (5 X 10(-7) M), amounted to 78% in the WKY and to 44% in the SHRSP preparation. In endothelium-removed aortae, sodium nitroprusside induced a comparable relaxation in both WKY and SHRSP preparations. These results indicate that the endothelium plays an important role in controlling the noradrenaline-induced contraction and that the lower influence of endothelium in the SHRSP aorta is most likely due to a decreased activity of this endothelium.
Acetylcholine↗