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S Othmani

Publications and source records attributed to S Othmani.

At least 19 recordsLinked to original sources
PubMed2006

[Legionnaire's disease complicated by acute renal failure due to rhabdomyolosis: a case report].

The infectious origin of non-traumatic rhabdomyolysis is rare (5% of cases). An elevated muscle enzyme level is often reported in the legionnaire's disease. We report the case of a 39-year-old male, with no previous medical history, admitted for renal failure (creatininemia=977 micromol/l) secondary to rhabdomyolysis and a twelve-day history of infectious syndrome with pneumonia in the left base. Legionella pneumophila was considered responsible for these symptoms because of a positive serology. The other microbial assessments were negative. After rehydration and three weeks of antibiotics, the outcome was favorable: the renal failure resolved completely and the muscle enzyme level returned to normal.

Acute Kidney Injury↗
PubMed2006

[Cytomegalovirus myelitis in immunocompetent adult].

INTRODUCTION: Cytomegalovirus (CMV) infection occurs in 40 to 100% of general population. It is often asymptomatic in immunocompetent subject but may induce neurological syndromes such as encephalitis and myelitis. CASE RECORD: We reported a case of a 64-years-old woman immunocompetent, with acute proximal upper and lower limb weakness, paresthesias and two episodes of urinary retention. MRI of the spine showed abnormal enhancement from cervical to lumbar spine indicative for myelitis. Diagnosis of CMV associated myelitis was confirmed by a positive CMV serology. Administration of ganciclovir was followed by a partial improvement in five months. DISCUSSION: Few cases of CMV acute myelitis in immunocompetent patients have been reported in the literature. The pathogenesis is not well known, however, immune-mediated central nervous system damage may be attributed to the pathogenesis of the disease. Early diagnosis and treatment improves the prognosis.

Antiviral Agents↗
PubMed2003

[Systemic lupus erythematosus in Tunisia. A multicentric study. About 295 cases].

PURPOSE: Systemic lupus erythematosus (SLE) is an autoimmune disease with a great clinical polymorphism. Wide variety of genetic, hormonal, immunological and environmental contributes to release the disease. Our objective was to describe and precise the epidemiological, clinical and immunological profile of this disease in Tunisia. METHOD: It is a retrospective study conducted by the Tunisian society of internal medicine during the period from January 1990 to December 1999. All patients fulfilled at least four of the revised American Rheumatism Association's criteria for SLE. RESULTS: Two hundred and ninety-five SLE have been examined (271 women, 24 men). The most frequent clinical manifestations were: articular 90%, malar rash 62%, photosensitivity 46%, seritis 32% and glomerulonephritis 56%, dominated by WHO class III and IV: 60 cases (renal biopsy was performed in 95 patients). Neurological features were observed in 14.5%. The abnormal laboratory findings were leucocytopenia 45%, lymphopenia 47%, thrombocytopenia 16% and hemolytic anemia in 6.7%. Antinuclear antibodies, anti-ds DNA and anti-Sm were at 92%, 74% and 57%, respectively. Eighty-three percent of patients were treated by steroids, and in 52 cases (18%), we added immunosuppressive drugs. Two hundred and eighteen patients were followed up with a mean follow-up duration of 51 months. Twenty-eight percent were in complete remission and in 60%, the SLE was active. In contrast, death occurred in 29 cases. CONCLUSION: Our study confirmed the clinical polymorphism of SLE, the great similarity with other studies apart the world, the gravity of renal and cardiac features and the infectious complications induced by corticosteroids.

Adolescent↗
PubMed2002

[Systemic lupus erythematosus in 24 tunisian males: clinico-biological analysis and clinical course].

PURPOSE: The systemic lupus erythematosus (SLE) is rare at the male. The clinic and biological characteristics and the evolution are variable between different studies. From 24 Tunisian observations we try to contribute to the precision of these characteristics on this ground. METHOD: It's a tunisian, multicentric, retrospective study of 24 males lupus, follow-up from 1990 to 1999 within a total lupus cohort of 295 patients. RESULTS: The sex-ratio female/male is 11/29, mean age at diagnosis is 31.75 years (range 10 to 63). The most frequent clinical manifestations are: arthritis (95%), malar rash (71%), photosensitivity (41%), glomerular nephropathy (66%) (classes III and IV = 7 cases/9), the serositis (37.5%) and Raynaud phenomenon (25%). Comparing these characteristics of two patient groups (24 males and 271 females), significant difference was observed : vascular thrombosis in male (16% vs 4% p : 0,027) and alopecia in female (12.5% vs 4% p : 0.03). For the other manifestations as nephropathy and serositis which are frequent in male the difference was not significant. The overall survival rate at 5 years 93% is and it was nearly the same in woman SLE patients. CONCLUSION: SLE in male is rare. In SLE male patients vascular thrombosis and nephropathy are more frequent without survival's influence.

Adolescent↗
PubMed2000

[Mediastinal fibrosis combined with Behçet's disease. Three case reports].

PURPOSE: Intrathoracic manifestations other then vascular aneurysm and thrombosis are rare in the course of Behçet's disease. Mediastinal fibrosis is also unusual. METHODS: Three cases of Behçet's disease with initial mediastinal fibrosis are reported. Diagnosis means, pathogenic mechanisms and therapeutic modalities are also more precisely defined. RESULTS: Three male patients (21, 25 and 27 years of age, respectively) were hospitalized for progressive vena cava superior syndrome accompanied by mediastinal fibrosis demonstrated by MRI and/or CT scan which both showed infiltration of the mediastinal fat. Multiple calcifications were also present in one patient. Histology was performed in one case. Thrombosis of the vena cava superior and innominata veins was associated with fibrosis in all three cases. Thrombosis of venae subclavia and left jugularis was also present in one case. Other manifestations leading to the diagnosis of Behçet's disease were demonstrated by the patient's history and, in one case, occurred on the fourth day of hospitalization. After initiation of a treatment including corticoids, anticoagulants and colchicine, the outcome was favorable in two cases. The third patient died. CONCLUSION: Mediastinal fibrosis combined with Behçet's disease has rarely been described. However, it should be included in manifestations of the disease. The causative process which might be vasculitis has to be demonstrated.

Adult↗
PubMed1999

[Arterial aneurysms and Behçet's disease: apropos of 3 cases].

PURPOSE: Results that were obtained from three patients and a literature review allow the authors to better define the place of medical and surgical treatments according to the different locations of arterial aneurysm occurring in the course of Behcet's disease. METHODS: Retrospective report of five cases of arterial aneurysm that occurred during Behcet's disease in three patients. RESULTS: Due to the unusual symptoms, diagnosis can be hampered. Though lesions may be observed in various areas, they were mostly aortic (two patients). Surgical revascularization was done in all three patients. It mainly involved prosthetic grafts. Two patients were subsequently treated by postoperative immunosuppressive drugs. The mean follow-up was 22 months. Relapsing aneurysm was observed in one patient, while in another patient aneurysm developed in a new location. CONCLUSION: These types of arterial lesions respond poorly to medical treatment when a combination of colchicine and intermittent intravenous bolus of cyclophosphamide is used. Surgical indications should be given great yet selected weight, using prosthetic rather than venous autologous grafts (due to the risk of spontaneous venous involvement). Since either complication or recurrence is possible, prolonged monitoring is required.

Adult↗
PubMed1994

[Varioliform gastritis or lymphocytic gastritis? Anatomoclinical study. Apropos of 14 cases].

The authors report 14 cases of lymphocytic gastritis, 13 of which correspond to an endoscopic appearance of varioliform gastritis. Epigastric pain was present in 91.6% of cases. Varioliform pattern corresponded to an antral site in 69.2% of cases and to the body in 30.8% of cases. Lymphocytic gastritis was diagnosed in 7 cases (46%), 6 of which corresponded to a varioliform gastritis. An associated duodenal ulcer was noted in 28.5% of our cases of lymphocytic gastritis.

Adolescent↗
PubMed1994

[Unusual localization of embryonal rhabdomyosarcoma of the gallbladder].

We report a second case of gallbladder embryonal rhabdomyosarcoma diagnosed in a 54 year old female. We had previously published a first similar case in a 48 year old male. In the review of the literature 5 other cases were collected. Five of the 7 cases occurred in 4 females and one male adult mean aged 63.4 years, and 2 in young girls aged 40 months. Three cases were of botryoid type, three were of alveolar type and one was of undetermined type. Immunohistochemistry demonstrated intra-cytoplasmic positivity of tumoral cells with anti-vimentin, anti-desmin and anti-actin anti-bodies. The prognosis remains bad. Death occurred, in 5 patients, in a period going from 18 days to 8 months after clinical diagnosis with a 5 months mean survival. The shortest survival was observed in a 40 month old child with AIDS. Only one case with surgical resection followed by radiochemotherapy had a 9 month survival.

Female↗
PubMed1992

[Value of immunohistochemistry with paraffin in malignant lymphoma of the lymphoid tissue associated to the mucosa (MALT) of the digestive tract. Apropos of 8 cases with complete review of the literature].

The authors report eight cases of MALT malignant lymphomas arising in the stomach in four cases, small intestine in two cases and salivary glands in two cases. The gastric lymphomas presented in the form of persistent epigastric pain sometimes lasting for several years, in patients with a mean age of 50.5 years. Gastroscopy revealed recurrent ulcerations in two cases and ulcerated or ulcero-fungating tumours in two cases. The two patients with alpha heavy chain disease, both 21 years of age, presented with chronic diarrhoea. The endoscopic appearance consisted of a pseudopolypoid tumour in one case and a mosaic appearance in the other case. The two salivary gland lymphomas involved the submandibular gland in two patients aged 30 years and 50 years. They presented in the form of nodules 1 and 2 cm in diameter, first detected by the patients two months and four months previously. Histological examination demonstrated the presence of typical lesions of MALT lymphoma with, in particular, the presence of constant lympho-epithelial lesions, various forms of centrocyte-like proliferation, varying degrees of plasma cell differentiation, reactive or residual lymphoid follicles in five cases, which were detected on biopsies in three cases. Immunohistochemistry confirmed the monoclonal nature of the tumour in seven cases, i.e. 87.5% of cases. The application of DBB42 and DNA7 antibodies onto paraffin sections demonstrated the absence of DNA7 labelling of CCL in line with Isaacson's findings in favour of the hypothesis of a non-centrofollicular origin of maltomas. Finally, we observed a single case of recurrence in a women with incomplete resection of the primary gastric tumour.

Adult↗