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Biomedical subjects

S Ottó

Publications and source records attributed to S Ottó.

4 recordsLinked to original sources
PubMed1979

Increased responsiveness of electric precipitation (electrosynerese) by means of a chemical method.

Electric precipitation is a method in serological diagnostics (determination of species-specificity). Since serum protein fractions (especially immunoglobulins) and extracts from blood stains migrate in agar-gel at pH 8.2--8.6 towards the cathode they cannot be used for the determination of the species specificity. By a chemical method using glutaraldehyde authors have produced an albumin-immunoglobulin complex, altering in this way the direction of electrophoretic mobility. Treatment of the blood samples with glutaraldehyde increases the sensitivity and realiability of the method.

Blood Protein Electrophoresis↗
PubMed1976

[Hypoxia and polytrauma].

The importance of polytrauma and hypoxia, resp., is discussed by the authors with regard to the mortality and the common effect of these is analysed. It was found that in the mortality of the patients suffered polytraumatism the first place (59,4%) is taken by such lesions, in which simultaneous lesion of the skull and the thorax occurs. The values of the blood gas and the acid-base balance of the patients who had suffered polytraumatism, were examined in the 12th--24th hours proceding the death. It was found that whereas--using the possibilities of the intensive therapy--the values of pH, paCO2 and BE could be kept in a part of the cases between the physiological limits--the paO2 value was under the normal value in all cases--moreover 2/3 of the values fell into the domain between 40--60 mmHg--signifying severe hypoxia. On the basis of the analysis it may be presumed that in the process leading to death of the patients who had suffered polytraumatism the anoxic hypoxy plays considerable role. This is supported also by the earlier data published by the institute, according to which the mortality in itself high--33.8%--of polytraumatism increases to 71.4%, if it is associated hypoxy. Consequently the aim of the therapy must be to exert the greatest activity in order to prevent or to combat, resp., the anoxic hypoxy.

Accidents↗
PubMed1975

The use of 75selenomethionine for labelling the formed and protein elements of the blood.

In the introduction the authors describe the biological role of platelets, plasma protein, fibrinogen and erthrocytes as well as the methods of tagging, separating and measuring them. The advantage of platelet labelling with 75selenomethionine is that it allows production and life-span to be determined simultaneously, however, the in vivo measurements do not give information on the site of platelet sequestration. Protein anabolism as well as katabolism can be evaluated with it, and the simultaneous determination of platelet and fibrinogen turnover may be especially useful in pathological conditions. The determination of erythrocyte life-span with 75 selenomethionine does not give so much information as the 59Fe and 51Cr methods, but when used for the examination of cell kinetics in combination with the latter methods it may afford an insight into erythropoiesis. The biological and the effective half-life periods (Teff) of 75selenomethionine are probably shorter than indicated in the literature.

Blood Cells↗