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Biomedical subjects

S Ozbas

Publications and source records attributed to S Ozbas.

7 recordsLinked to original sources
PubMed2003

Bone marrow micrometastasis in breast cancer.

BACKGROUND: Several studies have demonstrated that bone marrow micrometastasis in patients with breast cancer is an independent prognostic factor for systemic recurrence and poorer survival. METHODS: This review describes the detection and clinical significance of micrometastatic cells in bone marrow, and examines the correlation between such micrometastasis and established clinicopathological prognostic factors. The relevant English language literature on bone marrow micrometastasis in breast cancer was searched via Medline (1975-2002), cross-referencing with key articles on the subject. RESULTS AND CONCLUSION: The balance of evidence favours the hypothesis that bone marrow micrometastasis impacts on disease-free and overall survival. Further prospective studies are required to examine this in greater detail, with particular reference to early node-negative breast cancer and the value of adjuvant systemic therapy in patients with bone marrow micrometastasis.

Bone Marrow Examination↗
PubMed2003

Surgical management of primary hyperparathyroidism - results of a national survey.

BACKGROUND: During the last decade, the surgical management of primary hyperparathyroidism has been limited to those patients with symptoms or complications of the disease and most surgeons have advocated routine bilateral neck exploration. Several recent articles, however, have supported the role of early surgical intervention and minimally invasive surgery for these patients. The aim of this study was to define the current surgical management of primary hyperparathyroidism in the UK and Ireland. METHODS: A postal questionnaire was sent to all consultant members of the British Association of Endocrine Surgeons in November 2000. The surgeons were asked about their current criteria for patient selection, methods of pre-operative localisation, imaging technique before re-exploration, operative technique and follow-up. RESULTS: Questionnaires were returned from 66 of 92 surgeons (response rate 71.7%) currently performing parathyroid surgery in the UK and Ireland, at an average of 23.1 parathyroidectomies performed per annum (range, 5-120). The majority of patients referred for surgery were either asymptomatic (12.1%) or minimally symptomatic (53%). There was marked variability among surgeons in the use of pre-operative imaging techniques before the initial operation (sestamibi used by 39.4% [26/66] and ultrasound by 39.4% [26/66] also, alone or in combination with other imaging techniques, while 39.4% (26/66) of surgeons used no imaging) and re-exploration. CONCLUSIONS: This survey demonstrates marked variation in pre-operative localisation and surgical management of patients with primary hyperparathyroidism. The majority of surgeons in the UK and Ireland currently perform bilateral neck exploration with or without pre-operative localisation.

Adult↗
PubMed2000

Laparoscopic hepatic wedge resection of hemangioma: report of two cases.

INTRODUCTION: Cavernous hemangiomas are the most frequent type of benign liver tumor. A large proportion are discovered unexpectedly. The widespread use of ultrasound (US) and computerized tomography (CT) scanning has made diagnosis more common. Laparoscopic liver surgery has, however, developed more slowly. There have been only a few anecdotal reports of hepatic laparoscopic resections, most of which are limited to wedge resections. Laparoscopic anatomical liver resections are still at an early stage of development. DISCUSSION: This paper describes two cases of hepatic cavernous hemangiomas, both of which were removed laparoscopically. No blood transfusion was necessary. No surgical complications occurred and the patients were discharged on the second postoperative day. We conclude that, depending on the size and location of the tumor, laparoscopic resection of liver hemangiomas can be performed safely.

Cholecystectomy, Laparoscopic↗
PubMed1999

Fascioliasis observed during laparoscopic cholecystectomy.

Fascioliasis is an uncommon zoonotic disease caused by Fasciola hepatica, a liver fluke, for which humans act as an accidental host, infected by the ingestion of water or raw aquatic vegetables contaminated with the metacercaria. We report the case of a patient who presented to our clinic with right upper abdominal pain and nausea. Physical examination and abdominal ultrasonography revealed cholelithiasis. Peripheral blood eosinophilia was the only positive sign observed during routine laboratory tests. We therefore decided to perform laparoscopic cholecystectomy. During laparoscopy peritoneal implants approximately 0.5-1 cm diameter were detected which gave an impression of peritoneal carcinomatosa. Laparoscopic cholecystectomy was performed, and biopsies were taken from the peritoneal implants which were examined histopathologically, and fascioliasis was determined.

Animals↗
PubMed1999

Coeliac artery aneurysm: aorto-hepatic artery reconstruction.

Aneurysms of the coeliac axis are rare. Up to 1997, 137 cases had been reported. Here we present a coeliac aneurysm which involved the origin of the splenic, left gastric, and common hepatic arteries. After making a midline incision, infra-diaphragmatic control of the aorta was obtained. The aorta was clamped for 25 minutes to resect the aneurysm. The defect at the origin of the coeliac axis was closed with 1.5 cm PTFE patch. The distal segments of the splenic and left gastric arteries were ligated. A 6-mm ringed PTFE graft was interposed between the infra-renal aorta and the proper hepatic artery. The control arteriogram showed a good arterial flow. The patient recovered uneventfully after surgery with normalisation of hepatic function.

Adult↗
PubMed1998

Does pneumoperitoneum cause bacterial translocation?

Although extensive research has been carried out on the respiratory and renal effects of intra-abdominal pressure increase, there is limited research with regard to its effects on bacterial translocation. The objective of this study was to discuss whether the high intra-abdominal pressure due to carbon dioxide (CO2) insufflation during laparoscopy leads to bacterial translocation. Eighteen male dogs, 7 of which constituted the control group, were used in the study. Two study groups, in which the intra-abdominal pressure was raised to 15 mm Hg and kept at that level for 30 and 120 minutes, respectively, were set. Blood gases and blood pressure values were observed throughout the experiments. Samples of peritoneal smear, portal vein blood, mesenteric lymph node, liver, spleen, and cecum were examined to detect bacterial translocation. Histopathological examinations of all samples were also carried out. No translocation was detected in the samples of peritoneal smear, portal blood, mesenteric lymph node, liver, or spleen, but in the samples of cecum, bacterial colonization for the second group (p<0.05) and for the third group (p<0.05) was significantly higher compared with the control group. There was a considerable difference between the second and third groups (p<0.05). The changes in the mesenteric lymph nodes were interpreted to be a result of bacterial drainage. Histopathological examination disclosed active changes in the mesenteric lymph nodes in all groups, but there was considerable sinus histiocytosis only in the third group. We conclude that the intraabdominal pressure of 15 mm Hg created by carbon dioxide insufflation does not lead to bacterial translocation but causes intraluminal bacterial colonization in the cecum after 30 minutes and after 2 hours.

Animals↗