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Biomedical subjects

S Ozeki

Publications and source records attributed to S Ozeki.

At least 109 records · Page 6Linked to original sources
PubMed1985

Metastasis to the lingual lymph node in carcinoma of the tongue.

Lingual lymph nodes are occasionally found along the course of some lymph-vessels of the tongue. However, their existence has received little attention and metastasis of carcinoma of the tongue to them has not previously been reported. Three cases of carcinoma of the tongue with metastasis to the lingual lymph node are described and a discussion of the importance of such metastasis in the treatment of carcinoma of the tongue is presented.

Carcinoma, Squamous Cell↗
PubMed1985

Dose-dependent disposition of fractionated 3H-heparin in rats.

To investigate the disposition of fractionated 3H-heparin, commercial 3H-heparin was fractionated by affinity chromatography on protamine-Sepharose and subsequently by Sephadex G-100 chromatography. Effect of dose on the disposition of fractionated 3H-heparin was studied. At an early stage following the intravenous administration of fractionated 3H-heparin which had either affinity or non-affinity for protamine-Sepharose, elimination of the radioactivity from plasma was delayed with increasing dose. Even at 5 h after the administration when most radioactivity in plasma disappeared, the cumulative urinary recovery was only 4.8 to 8.4% of dose (1 to 15 microCi/kg), and 61 to 43% of dose was found in liver. Therefore, it was suggested that tissue (liver) distribution of radioactivity might be a predominant factor for the dose-dependent disappearance of the radioactivity from plasma at an early stage following the administration of fractionated 3H-heparin. Plasma radioactivity levels tended to be pseudo-steady state or to increase slightly after about 1 to 2 h following the administration of fractionated 3H-heparin. Participation of entero-hepatic circulation in this tendency was rejected.

Animals↗
PubMed1985

The change of p-aminohippuric acid disposition kinetics accompanied by growth in mice.

The change of disposition kinetics for p-aminohippuric acid (PAH) was studied following intravenous administration of p-[glycyl-1-14C]aminohippuric acid to 1-day-old, 1-week-old, 3-week-old and 8-week-old mice. The expiratory excretion of 14CO2 in 24 h following the administration was almost negligible in 1-day-old and 1-week-old mice in contrast to 3-week-old (6.8 +/- 1.8%) and 8-week-old (8.8 +/- 1.9%) mice. The ability to metabolize PAH may not be developed in these infant mice. The elimination of blood radioactivity following the administration was considerably delayed in 1-day-old and 1-week-old mice, especially in 1-day-old mice, suggesting that the renal tubular secretory function for PAH might not have been developed in the infant mice. Whole-body autoradiographic data showed that the transfer of PAH from blood to muscle was enhanced in 1-day-old and 1-week-old mice, especially in 1-day-old mice, compared to 3-week-old and 8-week-old mice. The enhanced muscular cell membrane permeability to PAH in 1-day-old and 1-week-old mice was considered to be the most plausible explanation for this result.

Age Factors↗
PubMed1984

Salivary excretion of urea in dogs.

The salivary excretion of urea was investigated by collecting parotid saliva (Pr) and mandibular-sublingual saliva (MS) separately in beagle dogs. (1) After intravenous administration of urea (1.5 g/kg), urea concentrations in both Pr and MS were well correlated to but were lower than those in plasma. Urea concentrations in MS were significantly lower than those in Pr (p less than 0.05), indicating that there was glandular difference in salivary excretion of urea. (2) This glandular difference was not explained by Matin's equation, even if all variation factors in this equation were considered. (3) At relatively low salivary flow rates, the increase in saliva/plasma urea concentration ratio (S/P ratio) for both Pr and MS was found in the experiments for endogenous urea. (4) At relatively low salivary flow rates, glandular difference was observed in the S/P ratios of sodium ion. (5) Salivary clearance of urea was highly dependent on salivary flow rate under stimulated condition for salivation, and mean value of the salivary clearance of urea was about 20% of its total body clearance.

Absorption↗
PubMed1984

Effect of hypothermia and ether anesthesia on the dispositions of creatinine and urea in mice.

Hypothermal mice were used under the anesthetized condition with ether to clarify the effect of diminished blood circulation on the dispositions of creatinine and urea which are considered to pass through the water-filled pores of biological membranes easily. The total body clearance of each chemical was considerably decreased in hypothermal mice compared with normal mice. This was considered to be caused by the decrease of glomerular filtration rate. The whole-body autoradiograms obtained following intravenous administration of 14C-urea and the rate of muscular blood flow showed that the transfer of urea from blood to muscle was apparently delayed by the decrease of muscular blood flow rate. However, the transfer of creatinine to muscle was not influenced by the change of muscular blood flow rate. This difference between creatinine and urea might be related to the higher permeability of muscular cell membrane to urea than to creatinine.

Anesthesia↗
PubMed1984

Disposition of salicylic acid in analbuminemic rats.

To clarify the role of albumin in the dispositions of drugs by in vivo experiment, analbuminemic rats were used and plasma-level analyses and whole-body autoradiography following intravenous administration of 14C-salicylic acid were carried out. The distribution volume of salicylic acid in analbuminemic rats (650 +/- 33 ml/kg) was remarkably larger than that in normal rats (180 +/- 3 ml/kg) (p less than 0.01). Whole-body autoradiograms demonstrated that transfer of salicylic acid from the blood to the liver, muscle and brain, especially to the liver, may be increased in analbuminemic rats. The increased distribution may be explained by the lack of plasma albumin, since the distribution of salicylic acid depends in part on plasma albumin binding. The total body clearance of salicylic acid in analbuminemic rats (12.2 +/- 1.4 ml/min/kg) was about 3.2 times that in normal rats (3.8 +/- 0.1 ml/min/kg) (p less than 0.01), suggesting that metabolic clearance and/or renal clearance is enhanced in analbuminemic rats. Increased extraction by the liver and/or the kidney due to increased free fraction in total (bound and unbound) plasma salicylic acid assumed to be responsible for this result.

Animals↗
PubMed1983

Treatment of carcinoma of the uterine cervix by remotely controlled afterloading intracavitary radiotherapy with high-dose rate: a comparative study with a low-dose rate system.

From September, 1974 through December, 1979, a total of 249 patients with carcinoma of the cervix uteri Stage IIb and III were randomly allocated to either remotely controlled high-dose-rate intracavitary radiotherapy or manual afterloading low-dose-rate therapy, with radiotherapy of 20 Gy in 2 weeks to Point A to whole pelvis and 40 Gy in 4 weeks to the parametria. The dose to Point A by intracavitary radiotherapy was 40-60 Gy with one or two fractions in the low-dose-rate group and 30 Gy for the high-dose-rate group by 3 fractions with a once a week schedule. The purpose of this paper is to compare the results between the groups and to clarify the problems in the high-dose-rate group clinically. The local control rate was higher in the high-dose-rate group; however, the complication rate was also higher in this group than in the low-dose-rate group. The dose schedule and the place of rectal dose measurement is discussed. The overall cumulative survival rate was nearly the same in both groups (55% at 5 years), although some difference was noted in each stage. The most common cause of death was distant metastasis outside the pelvis and the second most common was intercurrent disease in Stage IIb and local failure in Stage III.

Brachytherapy↗
PubMed1983

The change of disposition kinetics for creatinine and urea accompanied by growth in mice.

In order to clarify the change of disposition kinetics accompanied by growth, the whole-blood levels and whole-body autoradiography following intravenous administration of creatinine and urea, which are considered to pass through the water-filled pores of biological membranes easily, were investigated in 1-day-old, 1-week-old, 3-week-old and 8-week-old mice. For both creatinine and urea, the total body clearance was considerably lower in 1-day-old and 1-week-old mice than in more aged mice. Relatively lower renal clearance (i.e. rather incomplete renal function) in 1-day-old and 1-week-old mice was considered to be the major reason for this observation. Moreover, the lower metabolic clearance also seemed to be the cause in the case of urea, because the expiratory excretion of 14CO2 following the intravenous administration of 14C-urea was almost negligible in 1-day-old and 1-week-old mice in contrast to more aged (16-21%). The whole-body autoradiograms obtained following intravenous administration of 14C-creatinine indicated that creatinine was more rapidly transferred from blood to muscle in 1-day-old and 1-week-old mice, especially in 1-day-old mice, than in more aged mice. This might be caused by the difference in muscular blood flow rate or muscular cell membrane permeability to creatinine.

Aging↗
PubMed1983

The change of disposition kinetics for thiourea accompanied by growth in mice.

The whole blood levels and whole-body autoradiography following intravenous administration of thiourea, which is considered to covalently bind to the macromolecules in the body, were investigated in 1-day-old, 1-week-old, 3-week-old and 8-week-old mice in order to clarify the change of disposition kinetics accompanied by growth. The total body clearance for thiourea was remarkably lower in 1-day-old and 1-week-old mice than in more aged mice. The lower metabolic clearance as well as renal clearance in 1-day-old and 1-week-old mice seemed to be responsible for this observation. The whole-body autoradiograms obtained at 60 min following intravenous administration of 14C-thiourea showed the homogeneous distribution of radioactivity throughout the body in 1-day-old and 1-week-old mice and the high radioactivity localized in the liver and lung in more aged mice. This remarkable difference was assumed to be brought about by the difference in quantity of the macromolecules in the liver and lung which can covalently bind with thiourea. This assumption was supported by the result of gel filtration on Sephadex G-10 of the liver and lung homogenates.

Aging↗