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Biomedical subjects

S P Golyshenkov

Publications and source records attributed to S P Golyshenkov.

18 recordsLinked to original sources
PubMed1987

[Mechanism of fibrin formation in the tissues in gastric adenocarcinoma].

The investigation of extracts from intact and tumour tissues of the human stomach has revealed that adenocarcinoma tissues possess abnormal antiheparin, antithromboplastin and fibrin-stabilizing activity. Heparin activity, as well as the level of antithrombin III and fibrinogen-heparin complex were sharply reduced. The accumulation of anti-heparin compounds normalizing heparin and displacing the coagulating albumin from the complex with anticoagulant is believed to be one of the most important factors of fibrin production in the tumour.

Adenocarcinoma↗
PubMed1985

[Effect of the blockade of alpha- and beta adrenergic receptors on the release of hemocoagulating compounds from the intestine into the blood].

In acute experiments on cats, tropaphen (alpha-adrenoreceptor blocking agent) sharply increased the release of antithromboplastins into the intestinal vessels. The beta-adrenoreceptor blocking agent obsidan inhibited the antithromboplastin release. Both agents practically did not affect the intensity of release of other factors of blood coagulation and fibrinolysis. The control of antithromboplastin release in the intestine seems to occur with active participation of structures close by their features to alpha- and beta-adrenoreceptors.

Adrenergic alpha-Antagonists↗
PubMed1985

[Role of adrenergic structures in regulating the release by the intestines of hemocoagulating compounds into the blood stream].

Experiments on cats were made to study the capability of adrenaline, tropaphen and propranolol of influencing the intensity of the release of hemocoagulating compounds and anticoagulants from the intestinal vessels and tissues to the bloodstream (perfusate). Adrenaline was found to increase the coagulative activity of the perfusate, provoking an enhanced release into it of thromboplastin, an analogue of plasma factor V and antiheparin compounds and suppressing the release of antithromboplastins. The blockade of the alpha-adrenoreceptors was accompanied by a dramatic increase of antithromboplastins to the intestinal perfusate, whereas the depression of the activity of beta-adrenergic structures by reduction of the release of tissue thromboplastin inhibitors. It is concluded that regulation of the release of antithromboplastins in the intestine is mediated by the structures similar in their characteristics to alpha- and beta-adrenoreceptors.

Animals↗
PubMed1984

[Features of the effect of various doses of adrenaline on the release of blood clotting factors and anticoagulants into the bloodstream by the intestine].

Moderate doses (2-7 micrograms/kg) of adrenaline (A) enhanced the coagulating activity of the cat intestine perfusate sharply increasing the release of thromboplastine, antiheparin compounds, analogues of the V and XIII factors and depressing the release of antithromboplastines. Large doses of A (100 micrograms/kg) decreased the perfusate procoagulating activity accelerating the release of tissue antithromboplastines. The findings suggest an ability of large doses of A to induce a moderate hypocoagulemia due to the release of antithromboplastic substances from tissues into the blood flow.

Animals↗
PubMed1982

[Effect of acetylcholine and atropine on the release by the intestine of hemocoagulating substances into blood].

Acetylcholine entailed a release of substance possessing activity of the blood plasma antithrombin III into the intestinal vascular bed and activated to some extent the release of antifibrinolytic compounds. Atropin suppressed the antithrombin III release and obviously increased the perfusate's fibrinolytic activity. The parasympathetic portion of the vegetative nervous system evidently is able to regulate the release of compounds similar to antithrombin III and fibrinolysis inhibitors, from the vessels and tissues of intestine.

Acetylcholine↗