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Biomedical subjects

S P Grozdov

Publications and source records attributed to S P Grozdov.

At least 19 recordsLinked to original sources
PubMedDate not supplied

[The effect of thymectomy on several types of metabolism in tissues and on the concentration of corticosteroids in the blood of adult rats].

The concentration of 11-OCS in the blood plasma increased 2 weeks after thymectomy of adult rats; 3 to 4 weeks later this index fell to subnormal values. The following changes were observed in the spleen 2 to 4 weeks after the operation: a reduction of P-32 incorporation into the RNA and particularly into the DNA and also a fall of the ATP phosphate and lactic acid concentration with a simultaneous increase of P-32 incorporation into the whole tissue and of the K/Na ratio. With some reduction of ATP phosphate and in the absence of any increase in P-32 incorporation into the whole tissue there was an increase in P-32 incorporation into the RNA. The absence of such metabolic changes in case of false thymectomy and following splenectomy pointed to their specific dependence on the exclusion of the thymus function. Dynamics of these shifts failed to correlate with the changes in the 11-OCS content in the majority of the tissues.

11-Hydroxycorticosteroids↗
PubMedDate not supplied

[Changes in lipid metabolism in rats with radiation sickness and a pronounced intestinal syndrome following local irradiation of the abdominal region. Fatty acid composition of the blood and tissue phospholipids].

Local irradiation of rat abdomen (13.5 Gy) caused similar changes in fatty-acid composition of phospholipids in the liver, thymus and brain, that is: (a) a decrease in the polyunsaturated fatty acid content in 4 h, (b) a hypercompensatory increase in the content of polyunsaturated fatty acids (excluding thymus) in 24 h, the ratio between essential fatty acids and their derivatives being changed towards accumulation of the latter, and (c) a trend toward normalization in 72 h.

Abdomen↗
PubMedDate not supplied

[Effect of glutathione on the course of radiation sickness with a marked gastrointestinal syndrome and the effectiveness of parenteral feeding in an experiment].

Injections of oxidized glutathione (40 mg/kg, 5-7 days) combined with the parenteral nutrition (PN) of rats after local X-irradiation of abdomen (13-14.5 Gy) increased significantly the survival rate, decreased the gastrointestinal syndrome manifestations, and intensified the assimilation of a PF amino acid component. The reduced glutathione had no effect.

Acute Disease↗
PubMedDate not supplied

[Changes in lipid metabolism in rats with radiation sickness and a pronounced intestinal syndrome during parenteral feeding with lipofundin and infusolipol].

Local X-irradiation of rat abdomen (13.5 Gy) caused a pronounced intestinal syndrome which was partially coped with by parenteral feeding. The results indicate (1) a satisfactory assimilation of fatty emulsions used at certain doses and with certain parenteral diet composition, (2) a favourable effect of fatty emulsions on lipid metabolism in irradiated rats, and (3) some advantages of the parenteral feeding with infusolipol over lipofundin S.

Animals↗
PubMedDate not supplied

[Effect of local x-ray irradiation of the abdominal area on the amino acid content of the blood plasma and their urinary excretion in dogs and rats].

A study was made of the content of amino acids in blood plasma of dogs and rats and daily excretion thereof from rat body in urine after local X-irradiation of abdomen with a dose of 13.5 Gy. As the gastrointestinal syndrome developed the content and excretion of taurine increased, glucogenic amino acid content of plasma decreased, and the ratio of phenylalanine to tyrosine and branched-chain amino acids to aromatic amino acids changed. The ratio of arginine to ornithine and urea to ammonia sharply dropped in animals, which died later on, indicating that the urea-producing function of liver was impaired and hyperammonemia developed.

Abdomen↗