QUANTITATIVE SEROLOGIC AND ISOTOPIC STUDIES ON THE RH-O VARIANT--D-U.
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Biomedical subjects
Publications and source records attributed to S P MASOUREDIS.
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The uptake by red cells of I(131)-labeled nonagglutinating antibody to the Rh(0)(D) factor was dependent on the proportion of cells to antibody during sensitization. Inhibition of antibody binding by red cells in the region of antibody excess occurred with Rh(0)(D) positive red cells that were both papain modified and untreated; the inhibition was independent of the Rh phenotype.
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The Rh(o)(D) content of red cells obtained from different individuals as determined with I(181) anti-Rh(o)(D) showed a bimodal distribution. Family studies indicate that the cells with the lower antigen content represent the heterozygous Rh(o)(D) state and that the cells with 1.6 times more Rh(o)(D) correspond to the homozygous state.
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