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S P Modak

Publications and source records attributed to S P Modak.

50 records · Page 3Linked to original sources
PubMed1971

Age-associated changes in the DNA of mouse tissue.

The template activity of DNA with calf thymus DNA polymerase has been studied in sections of fixed brain, liver, and heart tissues from young and senescent mice. The enzyme catalyzed greater incorporation of deoxyribonucleotide monophosphates into nuclei of old mouse neurons, astrocytes, Kupffer cells, and heart muscle fibers. The results are interpreted as the accumulation of DNA strand breaks with aging.

Aging↗
PubMed1969

Synthesis of deoxyribonucleic acid after ultraviolet irradiation of sensitive and resistant Haemophilus influenzae.

Synthesis of deoxyribonucleic acid (DNA) has been measured as a function of ultraviolet (UV) radiation dose in wild-type and seven UV-sensitive strains of Haemophilus influenzae. At the UV doses used, all strains were able to resume DNA synthesis, even those which are unable to excise pyrimidine dimers from their DNA. These excisionless strains showed longer UV-induced delays in DNA synthesis than all but one of the other strains. The longest delay was shown by DB117, a strain which can excise dimers but which is recombination deficient and unable to rejoin X ray-induced single-strand breaks. All strains showed a progressive decrease in sensitivity as they approached the stationary phase.

DNA, Bacterial↗