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S P Pamra

Publications and source records attributed to S P Pamra.

15 recordsLinked to original sources
PubMed1976

Relapse in pulmonary tuberculosis.

Five hundred forty-three patients with bacteriologically confirmed pulmonary tuberculosis who successfully completed treatment were followed for 5 years to determine relapse rates and to see whether any factors could be said to predispose to relapse. Practically the entire treatment of these patients had been carried out in their homes. The cumulative relapse rate during a 5-year period was 11.60 per cent. Relapse rates were low during the first 2 years of follow-up. Of the various factors considered in the analysis, age, sex, initial extent of disease or cavitation, and presence of initial or emergent drug-resistant bacilli did not influence the relapse rate. Patients who achieved complete radiographic clearing at the time treatment was stopped and those who were regular in treatment had comparatively low relapse rates. Cured patients included in the study were asked to report at least once annually for a checkup, and immediately if they developed any symptoms suggestive of relapse. Only one fourth of the cases of relapse were detected during routine annual checkup; in the remaining cases, the patients attended ahead of the next due visit because of symptoms. This casts doubt on the utility of keeping cured patients under prolonged routine surveillance.

Adult↗
PubMed1972

Case-finding.

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Bacteriological Techniques↗
PubMed1971

Effects of chemoprophylaxis on minimal pulmonary tuberculosis lesions of doubtful activity.

In mass radiographic surveys, minimal pulmonary lesions of tuberculous appearance but doubtful activity are often found in persons without symptoms of tuberculosis. Whether to treat such persons or merely keep them under observation is a problem, as many of them manifest tuberculosis subsequently. The New Delhi Tuberculosis Centre carried out a controlled study from 1958 to 1968 to study this question in the conditions prevailing in India. A randomly selected group of persons with this type of lesion was given isoniazid prophylaxis for 1 year, a control group of almost equal size receiving placebo during the same period. Both were regularly re-examined, radiologically and bacteriologically, over a period of 6 years, and persons who developed clinical tuberculosis were immediately referred to the appropriate treatment services.THE RESULTS SHOW THAT THE TREATED PATIENTS FARED MUCH BETTER THAN THOSE IN THE CONTROL GROUP: fewer of them developed tuberculosis and more of them showed radiological improvement. This superiority was maintained for at least 4 years beyond the treatment year. However, this advantage must be weighed against the comparative inacceptability of treatment by such persons and the consequent high cost of organizing the treatment. It is concluded that, except when special circumstances justify it, prophylaxis of this kind cannot be recommended as a routine procedure.

Adolescent↗